Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation
Main Author: | |
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Publication Date: | 2009 |
Other Authors: | , |
Format: | Article |
Language: | eng |
Source: | Brazilian Journal of Medical and Biological Research |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000200001 |
Summary: | In this article, we will review some behavioral, pharmacological and neurochemical studies from our laboratory on mice, which might contribute to our understanding of the complex processes of memory consolidation and reconsolidation. We discuss the post-training (memory consolidation) and post-reactivation (memory reconsolidation) effects of icv infusions of hemicholinium, a central inhibitor of acetylcholine synthesis, of intraperitoneal administration of L-NAME, a non-specific inhibitor of nitric oxide synthase, of intrahippocampal injections of an inhibitor of the transcription factor NF-κB, and the exposure of mice to a new learning situation on retention performance of an inhibitory avoidance response. All treatments impair long-term memory consolidation and retrieval-induced memory processes different from extinction, probably in accordance with the "reconsolidation hypothesis". |
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Pharmacological effects and behavioral interventions on memory consolidation and reconsolidationMemoryConsolidationReconsolidationExtinctionInhibitory avoidanceIn this article, we will review some behavioral, pharmacological and neurochemical studies from our laboratory on mice, which might contribute to our understanding of the complex processes of memory consolidation and reconsolidation. We discuss the post-training (memory consolidation) and post-reactivation (memory reconsolidation) effects of icv infusions of hemicholinium, a central inhibitor of acetylcholine synthesis, of intraperitoneal administration of L-NAME, a non-specific inhibitor of nitric oxide synthase, of intrahippocampal injections of an inhibitor of the transcription factor NF-κB, and the exposure of mice to a new learning situation on retention performance of an inhibitory avoidance response. All treatments impair long-term memory consolidation and retrieval-induced memory processes different from extinction, probably in accordance with the "reconsolidation hypothesis".Associação Brasileira de Divulgação Científica2009-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000200001Brazilian Journal of Medical and Biological Research v.42 n.2 2009reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2009000200001info:eu-repo/semantics/openAccessBaratti,C.M.Boccia,M.M.Blake,M.G.eng2009-03-09T00:00:00Zoai:scielo:S0100-879X2009000200001Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2009-03-09T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation |
title |
Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation |
spellingShingle |
Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation Baratti,C.M. Memory Consolidation Reconsolidation Extinction Inhibitory avoidance |
title_short |
Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation |
title_full |
Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation |
title_fullStr |
Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation |
title_full_unstemmed |
Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation |
title_sort |
Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation |
author |
Baratti,C.M. |
author_facet |
Baratti,C.M. Boccia,M.M. Blake,M.G. |
author_role |
author |
author2 |
Boccia,M.M. Blake,M.G. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Baratti,C.M. Boccia,M.M. Blake,M.G. |
dc.subject.por.fl_str_mv |
Memory Consolidation Reconsolidation Extinction Inhibitory avoidance |
topic |
Memory Consolidation Reconsolidation Extinction Inhibitory avoidance |
description |
In this article, we will review some behavioral, pharmacological and neurochemical studies from our laboratory on mice, which might contribute to our understanding of the complex processes of memory consolidation and reconsolidation. We discuss the post-training (memory consolidation) and post-reactivation (memory reconsolidation) effects of icv infusions of hemicholinium, a central inhibitor of acetylcholine synthesis, of intraperitoneal administration of L-NAME, a non-specific inhibitor of nitric oxide synthase, of intrahippocampal injections of an inhibitor of the transcription factor NF-κB, and the exposure of mice to a new learning situation on retention performance of an inhibitory avoidance response. All treatments impair long-term memory consolidation and retrieval-induced memory processes different from extinction, probably in accordance with the "reconsolidation hypothesis". |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000200001 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000200001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-879X2009000200001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.42 n.2 2009 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302937190891520 |