Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100612 |
Resumo: | This study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study factors on drug absorption, including drug mass concentration, absorption site, and the different types and concentrations of absorption inhibitors. Within the scope of experimental concentrations, three curcumin constituents were absorbed in rat small intestines through the active transport mechanism. |
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Brazilian Journal of Medical and Biological Research |
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Absorption mechanism of three curcumin constituents through in situ intestinal perfusion methodCurcuminDemethoxycurcuminBisdethoxycurcuminIn situ intestinal perfusionAbsorption mechanismThis study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study factors on drug absorption, including drug mass concentration, absorption site, and the different types and concentrations of absorption inhibitors. Within the scope of experimental concentrations, three curcumin constituents were absorbed in rat small intestines through the active transport mechanism.Associação Brasileira de Divulgação Científica2017-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100612Brazilian Journal of Medical and Biological Research v.50 n.11 2017reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/1414-431x20176353info:eu-repo/semantics/openAccessWang,Y.-H.Ke,X.-M.Zhang,C.-H.Yang,R.-P.eng2019-03-19T00:00:00Zoai:scielo:S0100-879X2017001100612Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2019-03-19T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method |
title |
Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method |
spellingShingle |
Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method Wang,Y.-H. Curcumin Demethoxycurcumin Bisdethoxycurcumin In situ intestinal perfusion Absorption mechanism |
title_short |
Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method |
title_full |
Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method |
title_fullStr |
Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method |
title_full_unstemmed |
Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method |
title_sort |
Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method |
author |
Wang,Y.-H. |
author_facet |
Wang,Y.-H. Ke,X.-M. Zhang,C.-H. Yang,R.-P. |
author_role |
author |
author2 |
Ke,X.-M. Zhang,C.-H. Yang,R.-P. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Wang,Y.-H. Ke,X.-M. Zhang,C.-H. Yang,R.-P. |
dc.subject.por.fl_str_mv |
Curcumin Demethoxycurcumin Bisdethoxycurcumin In situ intestinal perfusion Absorption mechanism |
topic |
Curcumin Demethoxycurcumin Bisdethoxycurcumin In situ intestinal perfusion Absorption mechanism |
description |
This study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study factors on drug absorption, including drug mass concentration, absorption site, and the different types and concentrations of absorption inhibitors. Within the scope of experimental concentrations, three curcumin constituents were absorbed in rat small intestines through the active transport mechanism. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100612 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100612 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1414-431x20176353 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.50 n.11 2017 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302945904558080 |