Mathematical modeling of capsular polysaccharide production by Neisseria meningitidis serogroup C in bioreactors

Detalhes bibliográficos
Autor(a) principal: Henriques,A. W. S.
Data de Publicação: 2005
Outros Autores: Jessouroun,E., Lima,E. L., Alves,T. L. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Chemical Engineering
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322005000400011
Resumo: In this work, the process of capsular polysaccharide production by Neisseria meningitidis serogroup C was studied. Batch experimental runs were conducted in a set of one-liter bioreactors with 0.5 L of Frantz cultivation medium. Cultivation temperature and pH were controlled at optimal pre-established values. The dynamic behavior of the bacteria was analyzed based on biomass growth, glucose uptake, polysaccharide production and dissolved oxygen time profile obtained in a set of experimental runs with initial concentrations of glucose that varied from 5 to 13.5 g/L. Formulated hypotheses were then employed in the construction of a phenomenological model of the bioprocess under study that successfully described the dynamic behavior of the system and can be used in future control and optimization of the industrial process of capsular polysaccharide production.
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spelling Mathematical modeling of capsular polysaccharide production by Neisseria meningitidis serogroup C in bioreactorsBioreactorsCapsular polysaccharide productionOptimizationIn this work, the process of capsular polysaccharide production by Neisseria meningitidis serogroup C was studied. Batch experimental runs were conducted in a set of one-liter bioreactors with 0.5 L of Frantz cultivation medium. Cultivation temperature and pH were controlled at optimal pre-established values. The dynamic behavior of the bacteria was analyzed based on biomass growth, glucose uptake, polysaccharide production and dissolved oxygen time profile obtained in a set of experimental runs with initial concentrations of glucose that varied from 5 to 13.5 g/L. Formulated hypotheses were then employed in the construction of a phenomenological model of the bioprocess under study that successfully described the dynamic behavior of the system and can be used in future control and optimization of the industrial process of capsular polysaccharide production.Brazilian Society of Chemical Engineering2005-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322005000400011Brazilian Journal of Chemical Engineering v.22 n.4 2005reponame:Brazilian Journal of Chemical Engineeringinstname:Associação Brasileira de Engenharia Química (ABEQ)instacron:ABEQ10.1590/S0104-66322005000400011info:eu-repo/semantics/openAccessHenriques,A. W. S.Jessouroun,E.Lima,E. L.Alves,T. L. M.eng2006-01-02T00:00:00Zoai:scielo:S0104-66322005000400011Revistahttps://www.scielo.br/j/bjce/https://old.scielo.br/oai/scielo-oai.phprgiudici@usp.br||rgiudici@usp.br1678-43830104-6632opendoar:2006-01-02T00:00Brazilian Journal of Chemical Engineering - Associação Brasileira de Engenharia Química (ABEQ)false
dc.title.none.fl_str_mv Mathematical modeling of capsular polysaccharide production by Neisseria meningitidis serogroup C in bioreactors
title Mathematical modeling of capsular polysaccharide production by Neisseria meningitidis serogroup C in bioreactors
spellingShingle Mathematical modeling of capsular polysaccharide production by Neisseria meningitidis serogroup C in bioreactors
Henriques,A. W. S.
Bioreactors
Capsular polysaccharide production
Optimization
title_short Mathematical modeling of capsular polysaccharide production by Neisseria meningitidis serogroup C in bioreactors
title_full Mathematical modeling of capsular polysaccharide production by Neisseria meningitidis serogroup C in bioreactors
title_fullStr Mathematical modeling of capsular polysaccharide production by Neisseria meningitidis serogroup C in bioreactors
title_full_unstemmed Mathematical modeling of capsular polysaccharide production by Neisseria meningitidis serogroup C in bioreactors
title_sort Mathematical modeling of capsular polysaccharide production by Neisseria meningitidis serogroup C in bioreactors
author Henriques,A. W. S.
author_facet Henriques,A. W. S.
Jessouroun,E.
Lima,E. L.
Alves,T. L. M.
author_role author
author2 Jessouroun,E.
Lima,E. L.
Alves,T. L. M.
author2_role author
author
author
dc.contributor.author.fl_str_mv Henriques,A. W. S.
Jessouroun,E.
Lima,E. L.
Alves,T. L. M.
dc.subject.por.fl_str_mv Bioreactors
Capsular polysaccharide production
Optimization
topic Bioreactors
Capsular polysaccharide production
Optimization
description In this work, the process of capsular polysaccharide production by Neisseria meningitidis serogroup C was studied. Batch experimental runs were conducted in a set of one-liter bioreactors with 0.5 L of Frantz cultivation medium. Cultivation temperature and pH were controlled at optimal pre-established values. The dynamic behavior of the bacteria was analyzed based on biomass growth, glucose uptake, polysaccharide production and dissolved oxygen time profile obtained in a set of experimental runs with initial concentrations of glucose that varied from 5 to 13.5 g/L. Formulated hypotheses were then employed in the construction of a phenomenological model of the bioprocess under study that successfully described the dynamic behavior of the system and can be used in future control and optimization of the industrial process of capsular polysaccharide production.
publishDate 2005
dc.date.none.fl_str_mv 2005-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322005000400011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322005000400011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0104-66322005000400011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Brazilian Society of Chemical Engineering
publisher.none.fl_str_mv Brazilian Society of Chemical Engineering
dc.source.none.fl_str_mv Brazilian Journal of Chemical Engineering v.22 n.4 2005
reponame:Brazilian Journal of Chemical Engineering
instname:Associação Brasileira de Engenharia Química (ABEQ)
instacron:ABEQ
instname_str Associação Brasileira de Engenharia Química (ABEQ)
instacron_str ABEQ
institution ABEQ
reponame_str Brazilian Journal of Chemical Engineering
collection Brazilian Journal of Chemical Engineering
repository.name.fl_str_mv Brazilian Journal of Chemical Engineering - Associação Brasileira de Engenharia Química (ABEQ)
repository.mail.fl_str_mv rgiudici@usp.br||rgiudici@usp.br
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