Mathematical modeling of capsular polysaccharide production by Neisseria meningitidis serogroup C in bioreactors
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Chemical Engineering |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322005000400011 |
Resumo: | In this work, the process of capsular polysaccharide production by Neisseria meningitidis serogroup C was studied. Batch experimental runs were conducted in a set of one-liter bioreactors with 0.5 L of Frantz cultivation medium. Cultivation temperature and pH were controlled at optimal pre-established values. The dynamic behavior of the bacteria was analyzed based on biomass growth, glucose uptake, polysaccharide production and dissolved oxygen time profile obtained in a set of experimental runs with initial concentrations of glucose that varied from 5 to 13.5 g/L. Formulated hypotheses were then employed in the construction of a phenomenological model of the bioprocess under study that successfully described the dynamic behavior of the system and can be used in future control and optimization of the industrial process of capsular polysaccharide production. |
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Brazilian Journal of Chemical Engineering |
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Mathematical modeling of capsular polysaccharide production by Neisseria meningitidis serogroup C in bioreactorsBioreactorsCapsular polysaccharide productionOptimizationIn this work, the process of capsular polysaccharide production by Neisseria meningitidis serogroup C was studied. Batch experimental runs were conducted in a set of one-liter bioreactors with 0.5 L of Frantz cultivation medium. Cultivation temperature and pH were controlled at optimal pre-established values. The dynamic behavior of the bacteria was analyzed based on biomass growth, glucose uptake, polysaccharide production and dissolved oxygen time profile obtained in a set of experimental runs with initial concentrations of glucose that varied from 5 to 13.5 g/L. Formulated hypotheses were then employed in the construction of a phenomenological model of the bioprocess under study that successfully described the dynamic behavior of the system and can be used in future control and optimization of the industrial process of capsular polysaccharide production.Brazilian Society of Chemical Engineering2005-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322005000400011Brazilian Journal of Chemical Engineering v.22 n.4 2005reponame:Brazilian Journal of Chemical Engineeringinstname:Associação Brasileira de Engenharia Química (ABEQ)instacron:ABEQ10.1590/S0104-66322005000400011info:eu-repo/semantics/openAccessHenriques,A. W. S.Jessouroun,E.Lima,E. L.Alves,T. L. M.eng2006-01-02T00:00:00Zoai:scielo:S0104-66322005000400011Revistahttps://www.scielo.br/j/bjce/https://old.scielo.br/oai/scielo-oai.phprgiudici@usp.br||rgiudici@usp.br1678-43830104-6632opendoar:2006-01-02T00:00Brazilian Journal of Chemical Engineering - Associação Brasileira de Engenharia Química (ABEQ)false |
dc.title.none.fl_str_mv |
Mathematical modeling of capsular polysaccharide production by Neisseria meningitidis serogroup C in bioreactors |
title |
Mathematical modeling of capsular polysaccharide production by Neisseria meningitidis serogroup C in bioreactors |
spellingShingle |
Mathematical modeling of capsular polysaccharide production by Neisseria meningitidis serogroup C in bioreactors Henriques,A. W. S. Bioreactors Capsular polysaccharide production Optimization |
title_short |
Mathematical modeling of capsular polysaccharide production by Neisseria meningitidis serogroup C in bioreactors |
title_full |
Mathematical modeling of capsular polysaccharide production by Neisseria meningitidis serogroup C in bioreactors |
title_fullStr |
Mathematical modeling of capsular polysaccharide production by Neisseria meningitidis serogroup C in bioreactors |
title_full_unstemmed |
Mathematical modeling of capsular polysaccharide production by Neisseria meningitidis serogroup C in bioreactors |
title_sort |
Mathematical modeling of capsular polysaccharide production by Neisseria meningitidis serogroup C in bioreactors |
author |
Henriques,A. W. S. |
author_facet |
Henriques,A. W. S. Jessouroun,E. Lima,E. L. Alves,T. L. M. |
author_role |
author |
author2 |
Jessouroun,E. Lima,E. L. Alves,T. L. M. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Henriques,A. W. S. Jessouroun,E. Lima,E. L. Alves,T. L. M. |
dc.subject.por.fl_str_mv |
Bioreactors Capsular polysaccharide production Optimization |
topic |
Bioreactors Capsular polysaccharide production Optimization |
description |
In this work, the process of capsular polysaccharide production by Neisseria meningitidis serogroup C was studied. Batch experimental runs were conducted in a set of one-liter bioreactors with 0.5 L of Frantz cultivation medium. Cultivation temperature and pH were controlled at optimal pre-established values. The dynamic behavior of the bacteria was analyzed based on biomass growth, glucose uptake, polysaccharide production and dissolved oxygen time profile obtained in a set of experimental runs with initial concentrations of glucose that varied from 5 to 13.5 g/L. Formulated hypotheses were then employed in the construction of a phenomenological model of the bioprocess under study that successfully described the dynamic behavior of the system and can be used in future control and optimization of the industrial process of capsular polysaccharide production. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322005000400011 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322005000400011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0104-66322005000400011 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Chemical Engineering |
publisher.none.fl_str_mv |
Brazilian Society of Chemical Engineering |
dc.source.none.fl_str_mv |
Brazilian Journal of Chemical Engineering v.22 n.4 2005 reponame:Brazilian Journal of Chemical Engineering instname:Associação Brasileira de Engenharia Química (ABEQ) instacron:ABEQ |
instname_str |
Associação Brasileira de Engenharia Química (ABEQ) |
instacron_str |
ABEQ |
institution |
ABEQ |
reponame_str |
Brazilian Journal of Chemical Engineering |
collection |
Brazilian Journal of Chemical Engineering |
repository.name.fl_str_mv |
Brazilian Journal of Chemical Engineering - Associação Brasileira de Engenharia Química (ABEQ) |
repository.mail.fl_str_mv |
rgiudici@usp.br||rgiudici@usp.br |
_version_ |
1754213171932954624 |