Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista brasileira de hematologia e hemoterapia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842008000800009 |
Resumo: | Differentiation syndrome is a treatment complication which can occur in acute promyelocytic leukemia (APL) patients treated with all-trans retinoic acid (ATRA) or arsenic trioxide (ATO), which is characterized by enhanced leukocyte transmigration. Several cellular and molecular mechanisms participate in differentiation syndrome development. This review discusses the changes in expression of adhesion molecules induced during ATRA and ATO treatments and their possible implications in the pathogenesis of this potentially fatal complication. |
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Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factorsAcute promyelocytic leukemiaadhesion moleculesretinoidsarsenic trioxideDifferentiation syndrome is a treatment complication which can occur in acute promyelocytic leukemia (APL) patients treated with all-trans retinoic acid (ATRA) or arsenic trioxide (ATO), which is characterized by enhanced leukocyte transmigration. Several cellular and molecular mechanisms participate in differentiation syndrome development. This review discusses the changes in expression of adhesion molecules induced during ATRA and ATO treatments and their possible implications in the pathogenesis of this potentially fatal complication.Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular2008-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842008000800009Revista Brasileira de Hematologia e Hemoterapia v.30 suppl.2 2008reponame:Revista brasileira de hematologia e hemoterapia (Online)instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)instacron:ABHHTC10.1590/S1516-84842008000800009info:eu-repo/semantics/openAccessRego,Eduardo M.Santana-Lemos,Bárbara A. A.Tamarozzi,Mirela B.eng2008-12-09T00:00:00Zoai:scielo:S1516-84842008000800009Revistahttp://www.rbhh.org/pt/archivo/https://old.scielo.br/oai/scielo-oai.phpsbhh@terra.com.br||secretaria@rbhh.org1806-08701516-8484opendoar:2008-12-09T00:00Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)false |
dc.title.none.fl_str_mv |
Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors |
title |
Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors |
spellingShingle |
Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors Rego,Eduardo M. Acute promyelocytic leukemia adhesion molecules retinoids arsenic trioxide |
title_short |
Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors |
title_full |
Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors |
title_fullStr |
Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors |
title_full_unstemmed |
Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors |
title_sort |
Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors |
author |
Rego,Eduardo M. |
author_facet |
Rego,Eduardo M. Santana-Lemos,Bárbara A. A. Tamarozzi,Mirela B. |
author_role |
author |
author2 |
Santana-Lemos,Bárbara A. A. Tamarozzi,Mirela B. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Rego,Eduardo M. Santana-Lemos,Bárbara A. A. Tamarozzi,Mirela B. |
dc.subject.por.fl_str_mv |
Acute promyelocytic leukemia adhesion molecules retinoids arsenic trioxide |
topic |
Acute promyelocytic leukemia adhesion molecules retinoids arsenic trioxide |
description |
Differentiation syndrome is a treatment complication which can occur in acute promyelocytic leukemia (APL) patients treated with all-trans retinoic acid (ATRA) or arsenic trioxide (ATO), which is characterized by enhanced leukocyte transmigration. Several cellular and molecular mechanisms participate in differentiation syndrome development. This review discusses the changes in expression of adhesion molecules induced during ATRA and ATO treatments and their possible implications in the pathogenesis of this potentially fatal complication. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842008000800009 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842008000800009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-84842008000800009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular |
publisher.none.fl_str_mv |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular |
dc.source.none.fl_str_mv |
Revista Brasileira de Hematologia e Hemoterapia v.30 suppl.2 2008 reponame:Revista brasileira de hematologia e hemoterapia (Online) instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) instacron:ABHHTC |
instname_str |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) |
instacron_str |
ABHHTC |
institution |
ABHHTC |
reponame_str |
Revista brasileira de hematologia e hemoterapia (Online) |
collection |
Revista brasileira de hematologia e hemoterapia (Online) |
repository.name.fl_str_mv |
Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) |
repository.mail.fl_str_mv |
sbhh@terra.com.br||secretaria@rbhh.org |
_version_ |
1754213109120106496 |