Genes related to maintenance of autophagy and successful aging
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018001200831 |
Resumo: | ABSTRACT Considering aging as a phenomenon in which there is a decline in essential processes for cell survival, we investigated the autophagic and proteasome pathways in three different groups: young, older and oldest old male adults. The expression profile of autophagic pathway-related genes was carried out in peripheral blood, and the proteasome quantification was performed in plasma. No significant changes were found in plasma proteasome concentrations or in correlations between proteasome concentrations and ages. However, some autophagy- and/or apoptosis-related genes were differentially expressed. In addition, the network and enrichment analysis showed an interaction between four of the five differentially expressed genes and an association of these genes with the transcriptional process. Considering that the oldest old individuals maintained both the expression of genes linked to the autophagic machinery, and the proteasome levels, when compared with the older group, we concluded that these factors could be considered crucial for successful aging. |
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Arquivos de neuro-psiquiatria (Online) |
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Genes related to maintenance of autophagy and successful agingAutophagylongevitygene expressiongene networksproteasome endopeptidase complexABSTRACT Considering aging as a phenomenon in which there is a decline in essential processes for cell survival, we investigated the autophagic and proteasome pathways in three different groups: young, older and oldest old male adults. The expression profile of autophagic pathway-related genes was carried out in peripheral blood, and the proteasome quantification was performed in plasma. No significant changes were found in plasma proteasome concentrations or in correlations between proteasome concentrations and ages. However, some autophagy- and/or apoptosis-related genes were differentially expressed. In addition, the network and enrichment analysis showed an interaction between four of the five differentially expressed genes and an association of these genes with the transcriptional process. Considering that the oldest old individuals maintained both the expression of genes linked to the autophagic machinery, and the proteasome levels, when compared with the older group, we concluded that these factors could be considered crucial for successful aging.Academia Brasileira de Neurologia - ABNEURO2018-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018001200831Arquivos de Neuro-Psiquiatria v.76 n.12 2018reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20180142info:eu-repo/semantics/openAccessChaves,Carolina FiorotoMazzotti,Diego RoblesCendoroglo,Maysa SeabraRamos,Luiz RobertoTufik,SergioSilva,Vanessa Cavalcante daD'Almeida,Vâniaeng2019-01-18T00:00:00Zoai:scielo:S0004-282X2018001200831Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2019-01-18T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Genes related to maintenance of autophagy and successful aging |
title |
Genes related to maintenance of autophagy and successful aging |
spellingShingle |
Genes related to maintenance of autophagy and successful aging Chaves,Carolina Fioroto Autophagy longevity gene expression gene networks proteasome endopeptidase complex |
title_short |
Genes related to maintenance of autophagy and successful aging |
title_full |
Genes related to maintenance of autophagy and successful aging |
title_fullStr |
Genes related to maintenance of autophagy and successful aging |
title_full_unstemmed |
Genes related to maintenance of autophagy and successful aging |
title_sort |
Genes related to maintenance of autophagy and successful aging |
author |
Chaves,Carolina Fioroto |
author_facet |
Chaves,Carolina Fioroto Mazzotti,Diego Robles Cendoroglo,Maysa Seabra Ramos,Luiz Roberto Tufik,Sergio Silva,Vanessa Cavalcante da D'Almeida,Vânia |
author_role |
author |
author2 |
Mazzotti,Diego Robles Cendoroglo,Maysa Seabra Ramos,Luiz Roberto Tufik,Sergio Silva,Vanessa Cavalcante da D'Almeida,Vânia |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Chaves,Carolina Fioroto Mazzotti,Diego Robles Cendoroglo,Maysa Seabra Ramos,Luiz Roberto Tufik,Sergio Silva,Vanessa Cavalcante da D'Almeida,Vânia |
dc.subject.por.fl_str_mv |
Autophagy longevity gene expression gene networks proteasome endopeptidase complex |
topic |
Autophagy longevity gene expression gene networks proteasome endopeptidase complex |
description |
ABSTRACT Considering aging as a phenomenon in which there is a decline in essential processes for cell survival, we investigated the autophagic and proteasome pathways in three different groups: young, older and oldest old male adults. The expression profile of autophagic pathway-related genes was carried out in peripheral blood, and the proteasome quantification was performed in plasma. No significant changes were found in plasma proteasome concentrations or in correlations between proteasome concentrations and ages. However, some autophagy- and/or apoptosis-related genes were differentially expressed. In addition, the network and enrichment analysis showed an interaction between four of the five differentially expressed genes and an association of these genes with the transcriptional process. Considering that the oldest old individuals maintained both the expression of genes linked to the autophagic machinery, and the proteasome levels, when compared with the older group, we concluded that these factors could be considered crucial for successful aging. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018001200831 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018001200831 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282x20180142 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.76 n.12 2018 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
_version_ |
1754212784566960128 |