Brain sweet brain: importance of sugars for the cerebral microenvironment and tumor development

Detalhes bibliográficos
Autor(a) principal: Quirico-Santos,Thereza
Data de Publicação: 2010
Outros Autores: Fonseca,Clovis O, Lagrota-Candido,Jussara
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000500024
Resumo: The extracellular matrix (ECM) in the brain tissue is a complex network of glycoproteins and proteoglycans that fills the intercellular space serving as scaffolding to provide structural framework for the tissue and regulate the behavior of cells via specific receptors - integrins. There is enormous structural diversity among proteoglycans due to variation in the core protein, the number of glycosaminoglycans chains, the extent and position of sulfation. The lectican family of proteoglycans interacts with growth factors, hyaluronan and tenascin forming a complex structure that regulates neuronal plasticity and ion homeostasis around highly active neurons. In this review, we will discuss the latest insights into the roles of brain glycoproteins as modulators of cell adhesion, migration, neurite outgrowth and glial tumor invasion.
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spelling Brain sweet brain: importance of sugars for the cerebral microenvironment and tumor developmentglycoproteinsextracellular matrixbrain microenvironmentgliomaThe extracellular matrix (ECM) in the brain tissue is a complex network of glycoproteins and proteoglycans that fills the intercellular space serving as scaffolding to provide structural framework for the tissue and regulate the behavior of cells via specific receptors - integrins. There is enormous structural diversity among proteoglycans due to variation in the core protein, the number of glycosaminoglycans chains, the extent and position of sulfation. The lectican family of proteoglycans interacts with growth factors, hyaluronan and tenascin forming a complex structure that regulates neuronal plasticity and ion homeostasis around highly active neurons. In this review, we will discuss the latest insights into the roles of brain glycoproteins as modulators of cell adhesion, migration, neurite outgrowth and glial tumor invasion.Academia Brasileira de Neurologia - ABNEURO2010-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000500024Arquivos de Neuro-Psiquiatria v.68 n.5 2010reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2010000500024info:eu-repo/semantics/openAccessQuirico-Santos,TherezaFonseca,Clovis OLagrota-Candido,Jussaraeng2010-10-20T00:00:00Zoai:scielo:S0004-282X2010000500024Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2010-10-20T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Brain sweet brain: importance of sugars for the cerebral microenvironment and tumor development
title Brain sweet brain: importance of sugars for the cerebral microenvironment and tumor development
spellingShingle Brain sweet brain: importance of sugars for the cerebral microenvironment and tumor development
Quirico-Santos,Thereza
glycoproteins
extracellular matrix
brain microenvironment
glioma
title_short Brain sweet brain: importance of sugars for the cerebral microenvironment and tumor development
title_full Brain sweet brain: importance of sugars for the cerebral microenvironment and tumor development
title_fullStr Brain sweet brain: importance of sugars for the cerebral microenvironment and tumor development
title_full_unstemmed Brain sweet brain: importance of sugars for the cerebral microenvironment and tumor development
title_sort Brain sweet brain: importance of sugars for the cerebral microenvironment and tumor development
author Quirico-Santos,Thereza
author_facet Quirico-Santos,Thereza
Fonseca,Clovis O
Lagrota-Candido,Jussara
author_role author
author2 Fonseca,Clovis O
Lagrota-Candido,Jussara
author2_role author
author
dc.contributor.author.fl_str_mv Quirico-Santos,Thereza
Fonseca,Clovis O
Lagrota-Candido,Jussara
dc.subject.por.fl_str_mv glycoproteins
extracellular matrix
brain microenvironment
glioma
topic glycoproteins
extracellular matrix
brain microenvironment
glioma
description The extracellular matrix (ECM) in the brain tissue is a complex network of glycoproteins and proteoglycans that fills the intercellular space serving as scaffolding to provide structural framework for the tissue and regulate the behavior of cells via specific receptors - integrins. There is enormous structural diversity among proteoglycans due to variation in the core protein, the number of glycosaminoglycans chains, the extent and position of sulfation. The lectican family of proteoglycans interacts with growth factors, hyaluronan and tenascin forming a complex structure that regulates neuronal plasticity and ion homeostasis around highly active neurons. In this review, we will discuss the latest insights into the roles of brain glycoproteins as modulators of cell adhesion, migration, neurite outgrowth and glial tumor invasion.
publishDate 2010
dc.date.none.fl_str_mv 2010-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000500024
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000500024
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2010000500024
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.68 n.5 2010
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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