Demyelination in experimental intraventricular neurocysticercosis
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020000200103 |
Resumo: | Abstract Neurocysticercosis (NCC) is classified as a neglected tropical disease, which affects mainly Latin America and Africa in spite of some reports in North America and Europe. NCC represents the cause of up to 30% of the reported cases of epilepsy in endemic countries. The NCC injuries present direct relation to the development stage, location, and number of parasites as well as to the host immune response. This study aimed the characterization of the inflammatory response and tissue injuries by means of the analyses of the periventricular and parenchymatous demyelination through the experimental intraventricular NCC infection. Therefore, BALB/c mice were submitted to experimental NCC inoculation with Taenia crassiceps cysticerci. Their brains were removed at 7, 30, 60, and 90 days after the inoculation (DAI), and analyzed after staining with hematoxylin and eosin (HE), Luxol Fast Blue, and Nissl. It was possible to observe ventriculomegaly, inflammatory infiltration composed by polymorphonuclear and mononuclear cells, and foamy macrophages. The presence of inflammatory cells was associated with neurodegeneration detected by the areas with demyelination observed initially in the periventricular area and lately in the parenchyma. In conclusion, the presence of cysticerci and the consequent inflammation were able to promote initial periventricular demyelination followed by parenchymatous demyelination as the infection progressed. |
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Demyelination in experimental intraventricular neurocysticercosisneurocysticercosisperiventricular demyelinationparenchymal demyelinationTaenia crassicepsAbstract Neurocysticercosis (NCC) is classified as a neglected tropical disease, which affects mainly Latin America and Africa in spite of some reports in North America and Europe. NCC represents the cause of up to 30% of the reported cases of epilepsy in endemic countries. The NCC injuries present direct relation to the development stage, location, and number of parasites as well as to the host immune response. This study aimed the characterization of the inflammatory response and tissue injuries by means of the analyses of the periventricular and parenchymatous demyelination through the experimental intraventricular NCC infection. Therefore, BALB/c mice were submitted to experimental NCC inoculation with Taenia crassiceps cysticerci. Their brains were removed at 7, 30, 60, and 90 days after the inoculation (DAI), and analyzed after staining with hematoxylin and eosin (HE), Luxol Fast Blue, and Nissl. It was possible to observe ventriculomegaly, inflammatory infiltration composed by polymorphonuclear and mononuclear cells, and foamy macrophages. The presence of inflammatory cells was associated with neurodegeneration detected by the areas with demyelination observed initially in the periventricular area and lately in the parenchyma. In conclusion, the presence of cysticerci and the consequent inflammation were able to promote initial periventricular demyelination followed by parenchymatous demyelination as the infection progressed.Academia Brasileira de Neurologia - ABNEURO2020-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020000200103Arquivos de Neuro-Psiquiatria v.78 n.2 2020reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20190155info:eu-repo/semantics/openAccessMOURA,Vania Beatriz LopesMILHOMEM,Analia CirqueiraLIMA,Sarah BuzaimMATOS-SILVA,HidelbertoSUGITA,Denis MasashiVINAUD,Mariana ClareLINO-JÚNIOR,Ruy de Souzaeng2020-04-27T00:00:00Zoai:scielo:S0004-282X2020000200103Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2020-04-27T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Demyelination in experimental intraventricular neurocysticercosis |
title |
Demyelination in experimental intraventricular neurocysticercosis |
spellingShingle |
Demyelination in experimental intraventricular neurocysticercosis MOURA,Vania Beatriz Lopes neurocysticercosis periventricular demyelination parenchymal demyelination Taenia crassiceps |
title_short |
Demyelination in experimental intraventricular neurocysticercosis |
title_full |
Demyelination in experimental intraventricular neurocysticercosis |
title_fullStr |
Demyelination in experimental intraventricular neurocysticercosis |
title_full_unstemmed |
Demyelination in experimental intraventricular neurocysticercosis |
title_sort |
Demyelination in experimental intraventricular neurocysticercosis |
author |
MOURA,Vania Beatriz Lopes |
author_facet |
MOURA,Vania Beatriz Lopes MILHOMEM,Analia Cirqueira LIMA,Sarah Buzaim MATOS-SILVA,Hidelberto SUGITA,Denis Masashi VINAUD,Mariana Clare LINO-JÚNIOR,Ruy de Souza |
author_role |
author |
author2 |
MILHOMEM,Analia Cirqueira LIMA,Sarah Buzaim MATOS-SILVA,Hidelberto SUGITA,Denis Masashi VINAUD,Mariana Clare LINO-JÚNIOR,Ruy de Souza |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
MOURA,Vania Beatriz Lopes MILHOMEM,Analia Cirqueira LIMA,Sarah Buzaim MATOS-SILVA,Hidelberto SUGITA,Denis Masashi VINAUD,Mariana Clare LINO-JÚNIOR,Ruy de Souza |
dc.subject.por.fl_str_mv |
neurocysticercosis periventricular demyelination parenchymal demyelination Taenia crassiceps |
topic |
neurocysticercosis periventricular demyelination parenchymal demyelination Taenia crassiceps |
description |
Abstract Neurocysticercosis (NCC) is classified as a neglected tropical disease, which affects mainly Latin America and Africa in spite of some reports in North America and Europe. NCC represents the cause of up to 30% of the reported cases of epilepsy in endemic countries. The NCC injuries present direct relation to the development stage, location, and number of parasites as well as to the host immune response. This study aimed the characterization of the inflammatory response and tissue injuries by means of the analyses of the periventricular and parenchymatous demyelination through the experimental intraventricular NCC infection. Therefore, BALB/c mice were submitted to experimental NCC inoculation with Taenia crassiceps cysticerci. Their brains were removed at 7, 30, 60, and 90 days after the inoculation (DAI), and analyzed after staining with hematoxylin and eosin (HE), Luxol Fast Blue, and Nissl. It was possible to observe ventriculomegaly, inflammatory infiltration composed by polymorphonuclear and mononuclear cells, and foamy macrophages. The presence of inflammatory cells was associated with neurodegeneration detected by the areas with demyelination observed initially in the periventricular area and lately in the parenchyma. In conclusion, the presence of cysticerci and the consequent inflammation were able to promote initial periventricular demyelination followed by parenchymatous demyelination as the infection progressed. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020000200103 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020000200103 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282x20190155 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.78 n.2 2020 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
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