Brainstem auditory pathway of children with acute lymphoid leukemia on chemotherapy with methotrexate

Detalhes bibliográficos
Autor(a) principal: LEITE,Renata Aparecida
Data de Publicação: 2020
Outros Autores: VOSGRAU,Jéssica Sales, CORTEZ NETO,Leticia, SANTOS,Nayara Pereira, MATAS,Sandro Luiz de Andrade, ODONE FILHO,Vicente, MATAS,Carla Gentile
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020000200063
Resumo: Abstract Objective: Investigate the auditory pathway in the brainstem of children with acute lymphoblastic leukemia submitted to chemotherapy (by intravenous or intrathecal infusion). Methods: Fourteen children aged between 2 and 12 years with diagnosis of acute lymphoid leukemia were evaluated. The following procedures were used: meatoscopy, acoustic immitance measurements, tonal audiometry, vocal audiometry, transient otoacoustic emissions, and auditory brainstem response. Results: From the 14 children with normal auditory thresholds, 35.71% showed an alteration in auditory brainstem response, with a predominance of hearing impairment in the lower brainstem. It was found that 80% of the children with alteration had used intrathecal methotrexate less than 30 days and that 40% had the highest cumulative intravenous methotrexate doses. Conclusion: Children with acute lymphoblastic leukemia submitted to chemotherapy, present auditory pathway impairment in the brainstem, with a predominance of a low brainstem.
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spelling Brainstem auditory pathway of children with acute lymphoid leukemia on chemotherapy with methotrexatehearingelectrophysiologyprecursor cell lymphoblastic leukemia-lymphomadrug therapymethotrexatechildAbstract Objective: Investigate the auditory pathway in the brainstem of children with acute lymphoblastic leukemia submitted to chemotherapy (by intravenous or intrathecal infusion). Methods: Fourteen children aged between 2 and 12 years with diagnosis of acute lymphoid leukemia were evaluated. The following procedures were used: meatoscopy, acoustic immitance measurements, tonal audiometry, vocal audiometry, transient otoacoustic emissions, and auditory brainstem response. Results: From the 14 children with normal auditory thresholds, 35.71% showed an alteration in auditory brainstem response, with a predominance of hearing impairment in the lower brainstem. It was found that 80% of the children with alteration had used intrathecal methotrexate less than 30 days and that 40% had the highest cumulative intravenous methotrexate doses. Conclusion: Children with acute lymphoblastic leukemia submitted to chemotherapy, present auditory pathway impairment in the brainstem, with a predominance of a low brainstem.Academia Brasileira de Neurologia - ABNEURO2020-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020000200063Arquivos de Neuro-Psiquiatria v.78 n.2 2020reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20190139info:eu-repo/semantics/openAccessLEITE,Renata AparecidaVOSGRAU,Jéssica SalesCORTEZ NETO,LeticiaSANTOS,Nayara PereiraMATAS,Sandro Luiz de AndradeODONE FILHO,VicenteMATAS,Carla Gentileeng2020-04-27T00:00:00Zoai:scielo:S0004-282X2020000200063Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2020-04-27T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Brainstem auditory pathway of children with acute lymphoid leukemia on chemotherapy with methotrexate
title Brainstem auditory pathway of children with acute lymphoid leukemia on chemotherapy with methotrexate
spellingShingle Brainstem auditory pathway of children with acute lymphoid leukemia on chemotherapy with methotrexate
LEITE,Renata Aparecida
hearing
electrophysiology
precursor cell lymphoblastic leukemia-lymphoma
drug therapy
methotrexate
child
title_short Brainstem auditory pathway of children with acute lymphoid leukemia on chemotherapy with methotrexate
title_full Brainstem auditory pathway of children with acute lymphoid leukemia on chemotherapy with methotrexate
title_fullStr Brainstem auditory pathway of children with acute lymphoid leukemia on chemotherapy with methotrexate
title_full_unstemmed Brainstem auditory pathway of children with acute lymphoid leukemia on chemotherapy with methotrexate
title_sort Brainstem auditory pathway of children with acute lymphoid leukemia on chemotherapy with methotrexate
author LEITE,Renata Aparecida
author_facet LEITE,Renata Aparecida
VOSGRAU,Jéssica Sales
CORTEZ NETO,Leticia
SANTOS,Nayara Pereira
MATAS,Sandro Luiz de Andrade
ODONE FILHO,Vicente
MATAS,Carla Gentile
author_role author
author2 VOSGRAU,Jéssica Sales
CORTEZ NETO,Leticia
SANTOS,Nayara Pereira
MATAS,Sandro Luiz de Andrade
ODONE FILHO,Vicente
MATAS,Carla Gentile
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv LEITE,Renata Aparecida
VOSGRAU,Jéssica Sales
CORTEZ NETO,Leticia
SANTOS,Nayara Pereira
MATAS,Sandro Luiz de Andrade
ODONE FILHO,Vicente
MATAS,Carla Gentile
dc.subject.por.fl_str_mv hearing
electrophysiology
precursor cell lymphoblastic leukemia-lymphoma
drug therapy
methotrexate
child
topic hearing
electrophysiology
precursor cell lymphoblastic leukemia-lymphoma
drug therapy
methotrexate
child
description Abstract Objective: Investigate the auditory pathway in the brainstem of children with acute lymphoblastic leukemia submitted to chemotherapy (by intravenous or intrathecal infusion). Methods: Fourteen children aged between 2 and 12 years with diagnosis of acute lymphoid leukemia were evaluated. The following procedures were used: meatoscopy, acoustic immitance measurements, tonal audiometry, vocal audiometry, transient otoacoustic emissions, and auditory brainstem response. Results: From the 14 children with normal auditory thresholds, 35.71% showed an alteration in auditory brainstem response, with a predominance of hearing impairment in the lower brainstem. It was found that 80% of the children with alteration had used intrathecal methotrexate less than 30 days and that 40% had the highest cumulative intravenous methotrexate doses. Conclusion: Children with acute lymphoblastic leukemia submitted to chemotherapy, present auditory pathway impairment in the brainstem, with a predominance of a low brainstem.
publishDate 2020
dc.date.none.fl_str_mv 2020-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020000200063
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020000200063
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282x20190139
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.78 n.2 2020
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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