Spinocerebellar ataxia type 7 (SCA7): family princeps history, genealogy and geographical distribution
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000200010 |
Resumo: | We conducted a 320 year retrospective survey of the history and genealogy of a large Brazilian family with SCA7. The ancestral couple was from the State of Ceará, Brazil, and the genealogical tree was composed of 577 individuals, including 217 males (37.6%), 255 females (44.1%) and 105 individuals of unknown sex (18.1%). Based on collected information, the 118 individuals consistently affected were distributed in generations IV (n=2), V (n=28), VI (n=57), VII (n=25) and VIII (n=6) of the genealogical tree. Sixty affected members are alive, 37 of them (61.6%) live in the Northeast region, 12 (20%) in the Southeast, 9 (15%) in the Center-West and 2 (3.3%) in the North. This genealogical survey was based only on 4 of the 10 children of the ancestral couple since the destiny of the remaining 6 is unknown. We propose that other Brazilian families with SCA7 may have the same genetic origin. |
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Spinocerebellar ataxia type 7 (SCA7): family princeps history, genealogy and geographical distributionautosomal dominant cerebellar ataxia (ADCA)spinocerebellar ataxia type 7 (SCA7)neurodegenerative diseasetrinucleotide repeat expansionWe conducted a 320 year retrospective survey of the history and genealogy of a large Brazilian family with SCA7. The ancestral couple was from the State of Ceará, Brazil, and the genealogical tree was composed of 577 individuals, including 217 males (37.6%), 255 females (44.1%) and 105 individuals of unknown sex (18.1%). Based on collected information, the 118 individuals consistently affected were distributed in generations IV (n=2), V (n=28), VI (n=57), VII (n=25) and VIII (n=6) of the genealogical tree. Sixty affected members are alive, 37 of them (61.6%) live in the Northeast region, 12 (20%) in the Southeast, 9 (15%) in the Center-West and 2 (3.3%) in the North. This genealogical survey was based only on 4 of the 10 children of the ancestral couple since the destiny of the remaining 6 is unknown. We propose that other Brazilian families with SCA7 may have the same genetic origin.Academia Brasileira de Neurologia - ABNEURO2006-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000200010Arquivos de Neuro-Psiquiatria v.64 n.2a 2006reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2006000200010info:eu-repo/semantics/openAccessLinhares,Salomão da CunhaHorta,Wagner GoesMarques Júnior,Wilsoneng2006-06-07T00:00:00Zoai:scielo:S0004-282X2006000200010Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2006-06-07T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Spinocerebellar ataxia type 7 (SCA7): family princeps history, genealogy and geographical distribution |
title |
Spinocerebellar ataxia type 7 (SCA7): family princeps history, genealogy and geographical distribution |
spellingShingle |
Spinocerebellar ataxia type 7 (SCA7): family princeps history, genealogy and geographical distribution Linhares,Salomão da Cunha autosomal dominant cerebellar ataxia (ADCA) spinocerebellar ataxia type 7 (SCA7) neurodegenerative disease trinucleotide repeat expansion |
title_short |
Spinocerebellar ataxia type 7 (SCA7): family princeps history, genealogy and geographical distribution |
title_full |
Spinocerebellar ataxia type 7 (SCA7): family princeps history, genealogy and geographical distribution |
title_fullStr |
Spinocerebellar ataxia type 7 (SCA7): family princeps history, genealogy and geographical distribution |
title_full_unstemmed |
Spinocerebellar ataxia type 7 (SCA7): family princeps history, genealogy and geographical distribution |
title_sort |
Spinocerebellar ataxia type 7 (SCA7): family princeps history, genealogy and geographical distribution |
author |
Linhares,Salomão da Cunha |
author_facet |
Linhares,Salomão da Cunha Horta,Wagner Goes Marques Júnior,Wilson |
author_role |
author |
author2 |
Horta,Wagner Goes Marques Júnior,Wilson |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Linhares,Salomão da Cunha Horta,Wagner Goes Marques Júnior,Wilson |
dc.subject.por.fl_str_mv |
autosomal dominant cerebellar ataxia (ADCA) spinocerebellar ataxia type 7 (SCA7) neurodegenerative disease trinucleotide repeat expansion |
topic |
autosomal dominant cerebellar ataxia (ADCA) spinocerebellar ataxia type 7 (SCA7) neurodegenerative disease trinucleotide repeat expansion |
description |
We conducted a 320 year retrospective survey of the history and genealogy of a large Brazilian family with SCA7. The ancestral couple was from the State of Ceará, Brazil, and the genealogical tree was composed of 577 individuals, including 217 males (37.6%), 255 females (44.1%) and 105 individuals of unknown sex (18.1%). Based on collected information, the 118 individuals consistently affected were distributed in generations IV (n=2), V (n=28), VI (n=57), VII (n=25) and VIII (n=6) of the genealogical tree. Sixty affected members are alive, 37 of them (61.6%) live in the Northeast region, 12 (20%) in the Southeast, 9 (15%) in the Center-West and 2 (3.3%) in the North. This genealogical survey was based only on 4 of the 10 children of the ancestral couple since the destiny of the remaining 6 is unknown. We propose that other Brazilian families with SCA7 may have the same genetic origin. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000200010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000200010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2006000200010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.64 n.2a 2006 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212759703126016 |