Correlation between presence of Leishmania RNA virus 1 and clinical characteristics of nasal mucosal leishmaniosis
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Otorhinolaryngology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942015000500533 |
Resumo: | ABSTRACT INTRODUCTION: Mucosal leishmaniosis (ML) is a severe clinical form of leishmaniosis. Complex factors related to the parasite and the host are attributed to the development of mucosal lesions. Leishmania RNA virus 1 (LRV1) can disrupt immune response, and may be the main determinant of severity of the disease; it should be investigated. OBJECTIVE: To study the existence of clinical differences between patients with ML with endosymbiosis by LRV1 and. those without it. METHODS: A cross-sectional cohort study with clinical evaluation, polymerase chain reaction (PCR) detection of Leishmania, species classification, and search of LRV1 was performed. Only patients with confirmed diagnosis of ML by positive PCR and with nasal mucosa injuries were included in this analysis. RESULTS: Out of 37 patients, 30 (81.1%) were diagnosed with Leishmania braziliensis, five (13.5%) with Leishmania guyanensis, and two (5.4%) with mixed infection of L. braziliensis and L. guyanensis. LVR1 virus was present in 26 (70.3%) of the cases. CONCLUSION: Correlation between clinical phenotype and presence of LRV1 was not observed, although the frequency of the virus is two-fold higher in mucosal lesions than that found in the literature on skin lesions in the same geographical area. |
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Brazilian Journal of Otorhinolaryngology |
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Correlation between presence of Leishmania RNA virus 1 and clinical characteristics of nasal mucosal leishmaniosisLeishmaniosis mucocutaneousLeishmaniosisLeishmania braziliensisLeishmania guyanensisLeishmaniavirusABSTRACT INTRODUCTION: Mucosal leishmaniosis (ML) is a severe clinical form of leishmaniosis. Complex factors related to the parasite and the host are attributed to the development of mucosal lesions. Leishmania RNA virus 1 (LRV1) can disrupt immune response, and may be the main determinant of severity of the disease; it should be investigated. OBJECTIVE: To study the existence of clinical differences between patients with ML with endosymbiosis by LRV1 and. those without it. METHODS: A cross-sectional cohort study with clinical evaluation, polymerase chain reaction (PCR) detection of Leishmania, species classification, and search of LRV1 was performed. Only patients with confirmed diagnosis of ML by positive PCR and with nasal mucosa injuries were included in this analysis. RESULTS: Out of 37 patients, 30 (81.1%) were diagnosed with Leishmania braziliensis, five (13.5%) with Leishmania guyanensis, and two (5.4%) with mixed infection of L. braziliensis and L. guyanensis. LVR1 virus was present in 26 (70.3%) of the cases. CONCLUSION: Correlation between clinical phenotype and presence of LRV1 was not observed, although the frequency of the virus is two-fold higher in mucosal lesions than that found in the literature on skin lesions in the same geographical area.Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.2015-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942015000500533Brazilian Journal of Otorhinolaryngology v.81 n.5 2015reponame:Brazilian Journal of Otorhinolaryngologyinstname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)instacron:ABORL-CCF10.1016/j.bjorl.2015.07.014info:eu-repo/semantics/openAccessIto,Marcos MassayukiCatanhêde,Lilian MottaKatsuragawa,Tony HiroshiSilva Junior,Cipriano Ferreira daCamargo,Luis Marcelo AranhaMattos,Ricardo de GodoiVilallobos-Salcedo,Juan Migueleng2015-11-24T00:00:00Zoai:scielo:S1808-86942015000500533Revistahttp://www.bjorl.org.br/https://old.scielo.br/oai/scielo-oai.phprevista@aborlccf.org.br||revista@aborlccf.org.br1808-86861808-8686opendoar:2015-11-24T00:00Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)false |
dc.title.none.fl_str_mv |
Correlation between presence of Leishmania RNA virus 1 and clinical characteristics of nasal mucosal leishmaniosis |
title |
Correlation between presence of Leishmania RNA virus 1 and clinical characteristics of nasal mucosal leishmaniosis |
spellingShingle |
Correlation between presence of Leishmania RNA virus 1 and clinical characteristics of nasal mucosal leishmaniosis Ito,Marcos Massayuki Leishmaniosis mucocutaneous Leishmaniosis Leishmania braziliensis Leishmania guyanensis Leishmaniavirus |
title_short |
Correlation between presence of Leishmania RNA virus 1 and clinical characteristics of nasal mucosal leishmaniosis |
title_full |
Correlation between presence of Leishmania RNA virus 1 and clinical characteristics of nasal mucosal leishmaniosis |
title_fullStr |
Correlation between presence of Leishmania RNA virus 1 and clinical characteristics of nasal mucosal leishmaniosis |
title_full_unstemmed |
Correlation between presence of Leishmania RNA virus 1 and clinical characteristics of nasal mucosal leishmaniosis |
title_sort |
Correlation between presence of Leishmania RNA virus 1 and clinical characteristics of nasal mucosal leishmaniosis |
author |
Ito,Marcos Massayuki |
author_facet |
Ito,Marcos Massayuki Catanhêde,Lilian Motta Katsuragawa,Tony Hiroshi Silva Junior,Cipriano Ferreira da Camargo,Luis Marcelo Aranha Mattos,Ricardo de Godoi Vilallobos-Salcedo,Juan Miguel |
author_role |
author |
author2 |
Catanhêde,Lilian Motta Katsuragawa,Tony Hiroshi Silva Junior,Cipriano Ferreira da Camargo,Luis Marcelo Aranha Mattos,Ricardo de Godoi Vilallobos-Salcedo,Juan Miguel |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Ito,Marcos Massayuki Catanhêde,Lilian Motta Katsuragawa,Tony Hiroshi Silva Junior,Cipriano Ferreira da Camargo,Luis Marcelo Aranha Mattos,Ricardo de Godoi Vilallobos-Salcedo,Juan Miguel |
dc.subject.por.fl_str_mv |
Leishmaniosis mucocutaneous Leishmaniosis Leishmania braziliensis Leishmania guyanensis Leishmaniavirus |
topic |
Leishmaniosis mucocutaneous Leishmaniosis Leishmania braziliensis Leishmania guyanensis Leishmaniavirus |
description |
ABSTRACT INTRODUCTION: Mucosal leishmaniosis (ML) is a severe clinical form of leishmaniosis. Complex factors related to the parasite and the host are attributed to the development of mucosal lesions. Leishmania RNA virus 1 (LRV1) can disrupt immune response, and may be the main determinant of severity of the disease; it should be investigated. OBJECTIVE: To study the existence of clinical differences between patients with ML with endosymbiosis by LRV1 and. those without it. METHODS: A cross-sectional cohort study with clinical evaluation, polymerase chain reaction (PCR) detection of Leishmania, species classification, and search of LRV1 was performed. Only patients with confirmed diagnosis of ML by positive PCR and with nasal mucosa injuries were included in this analysis. RESULTS: Out of 37 patients, 30 (81.1%) were diagnosed with Leishmania braziliensis, five (13.5%) with Leishmania guyanensis, and two (5.4%) with mixed infection of L. braziliensis and L. guyanensis. LVR1 virus was present in 26 (70.3%) of the cases. CONCLUSION: Correlation between clinical phenotype and presence of LRV1 was not observed, although the frequency of the virus is two-fold higher in mucosal lesions than that found in the literature on skin lesions in the same geographical area. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942015000500533 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942015000500533 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjorl.2015.07.014 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. |
publisher.none.fl_str_mv |
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. |
dc.source.none.fl_str_mv |
Brazilian Journal of Otorhinolaryngology v.81 n.5 2015 reponame:Brazilian Journal of Otorhinolaryngology instname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF) instacron:ABORL-CCF |
instname_str |
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF) |
instacron_str |
ABORL-CCF |
institution |
ABORL-CCF |
reponame_str |
Brazilian Journal of Otorhinolaryngology |
collection |
Brazilian Journal of Otorhinolaryngology |
repository.name.fl_str_mv |
Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF) |
repository.mail.fl_str_mv |
revista@aborlccf.org.br||revista@aborlccf.org.br |
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1754575991692328960 |