Heterogeneous trajectories in schizophrenia: insights from neurodevelopment and neuroprogression models
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462022000100074 |
Resumo: | The notion that schizophrenia is a neuroprogressive disorder is based on clinical perception of cumulative impairments over time and is supported by neuroimaging and biomarker research. Nevertheless, increasing evidence has indicated that schizophrenia first emerges as a neurodevelopmental disorder that could follow various pathways, some of them neuroprogressive. The objective of this review is to revisit basic research on cognitive processes and neuroimaging findings in a search for candidate keys to the intricate connections between neurodevelopment and neuroprogression in schizophrenia. In the complete panorama, schizophrenia is a neurodevelopmental disorder, possibly associated with an additional burden over the course of the disease through pathologically accelerated aging, and cognitive heterogeneity may explain the different trajectories of each patient. |
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Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
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Heterogeneous trajectories in schizophrenia: insights from neurodevelopment and neuroprogression modelsSchizophreniacognitionagingneurodevelopmentneuroprogressionThe notion that schizophrenia is a neuroprogressive disorder is based on clinical perception of cumulative impairments over time and is supported by neuroimaging and biomarker research. Nevertheless, increasing evidence has indicated that schizophrenia first emerges as a neurodevelopmental disorder that could follow various pathways, some of them neuroprogressive. The objective of this review is to revisit basic research on cognitive processes and neuroimaging findings in a search for candidate keys to the intricate connections between neurodevelopment and neuroprogression in schizophrenia. In the complete panorama, schizophrenia is a neurodevelopmental disorder, possibly associated with an additional burden over the course of the disease through pathologically accelerated aging, and cognitive heterogeneity may explain the different trajectories of each patient.Associação Brasileira de Psiquiatria2022-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462022000100074Brazilian Journal of Psychiatry v.44 n.1 2022reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABP10.1590/1516-4446-2020-1670info:eu-repo/semantics/openAccessReckziegel,RamiroCzepielewski,Letícia S.Hasse-Sousa,MathiasMartins,Dayane S.de Britto,Maria J.Lapa,Clara de O.Schwartzhaupt,Alexandre W.Gama,Clarissa S.eng2022-02-11T00:00:00Zoai:scielo:S1516-44462022000100074Revistahttp://www.bjp.org.br/ahead_of_print.asphttps://old.scielo.br/oai/scielo-oai.php||rbp@abpbrasil.org.br1809-452X1516-4446opendoar:2022-02-11T00:00Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)false |
dc.title.none.fl_str_mv |
Heterogeneous trajectories in schizophrenia: insights from neurodevelopment and neuroprogression models |
title |
Heterogeneous trajectories in schizophrenia: insights from neurodevelopment and neuroprogression models |
spellingShingle |
Heterogeneous trajectories in schizophrenia: insights from neurodevelopment and neuroprogression models Reckziegel,Ramiro Schizophrenia cognition aging neurodevelopment neuroprogression |
title_short |
Heterogeneous trajectories in schizophrenia: insights from neurodevelopment and neuroprogression models |
title_full |
Heterogeneous trajectories in schizophrenia: insights from neurodevelopment and neuroprogression models |
title_fullStr |
Heterogeneous trajectories in schizophrenia: insights from neurodevelopment and neuroprogression models |
title_full_unstemmed |
Heterogeneous trajectories in schizophrenia: insights from neurodevelopment and neuroprogression models |
title_sort |
Heterogeneous trajectories in schizophrenia: insights from neurodevelopment and neuroprogression models |
author |
Reckziegel,Ramiro |
author_facet |
Reckziegel,Ramiro Czepielewski,Letícia S. Hasse-Sousa,Mathias Martins,Dayane S. de Britto,Maria J. Lapa,Clara de O. Schwartzhaupt,Alexandre W. Gama,Clarissa S. |
author_role |
author |
author2 |
Czepielewski,Letícia S. Hasse-Sousa,Mathias Martins,Dayane S. de Britto,Maria J. Lapa,Clara de O. Schwartzhaupt,Alexandre W. Gama,Clarissa S. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Reckziegel,Ramiro Czepielewski,Letícia S. Hasse-Sousa,Mathias Martins,Dayane S. de Britto,Maria J. Lapa,Clara de O. Schwartzhaupt,Alexandre W. Gama,Clarissa S. |
dc.subject.por.fl_str_mv |
Schizophrenia cognition aging neurodevelopment neuroprogression |
topic |
Schizophrenia cognition aging neurodevelopment neuroprogression |
description |
The notion that schizophrenia is a neuroprogressive disorder is based on clinical perception of cumulative impairments over time and is supported by neuroimaging and biomarker research. Nevertheless, increasing evidence has indicated that schizophrenia first emerges as a neurodevelopmental disorder that could follow various pathways, some of them neuroprogressive. The objective of this review is to revisit basic research on cognitive processes and neuroimaging findings in a search for candidate keys to the intricate connections between neurodevelopment and neuroprogression in schizophrenia. In the complete panorama, schizophrenia is a neurodevelopmental disorder, possibly associated with an additional burden over the course of the disease through pathologically accelerated aging, and cognitive heterogeneity may explain the different trajectories of each patient. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462022000100074 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462022000100074 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1516-4446-2020-1670 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
dc.source.none.fl_str_mv |
Brazilian Journal of Psychiatry v.44 n.1 2022 reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online) instname:Associação Brasileira de Psiquiatria (ABP) instacron:ABP |
instname_str |
Associação Brasileira de Psiquiatria (ABP) |
instacron_str |
ABP |
institution |
ABP |
reponame_str |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
collection |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
repository.name.fl_str_mv |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP) |
repository.mail.fl_str_mv |
||rbp@abpbrasil.org.br |
_version_ |
1754212560564912128 |