Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications

Detalhes bibliográficos
Autor(a) principal: Echeverría,María Gabriela
Data de Publicação: 2015
Outros Autores: Pardini,Oscar Ricardo, Debandi,María Valeria, François,Nora Judit, Daraio,Marta Edith, Amalvy,Javier Ignacio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Polímeros (São Carlos. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282015000400336
Resumo: AbstractA pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film-forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity at different pHs. The drug release profile of films was evaluated using a vertical Franz Cell and theophylline as model drug. The water swelling degree increases from 54 to 180% when the pH of the medium is changed from 6 to 2, demonstrating the pH-responsive behavior of the film. The in-vitro release studies indicate that an anomalous transport mechanism governs the theophylline release.
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spelling Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applicationspolyurethanesdrug delivery systemsstimuli-sensitive polymersswellingtheophyllineAbstractA pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film-forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity at different pHs. The drug release profile of films was evaluated using a vertical Franz Cell and theophylline as model drug. The water swelling degree increases from 54 to 180% when the pH of the medium is changed from 6 to 2, demonstrating the pH-responsive behavior of the film. The in-vitro release studies indicate that an anomalous transport mechanism governs the theophylline release.Associação Brasileira de Polímeros2015-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282015000400336Polímeros v.25 n.4 2015reponame:Polímeros (São Carlos. Online)instname:Associação Brasileira de Polímeros (ABPol)instacron:ABPO10.1590/0104-1428.1716info:eu-repo/semantics/openAccessEcheverría,María GabrielaPardini,Oscar RicardoDebandi,María ValeriaFrançois,Nora JuditDaraio,Marta EdithAmalvy,Javier Ignacioeng2015-10-05T00:00:00Zoai:scielo:S0104-14282015000400336Revistahttp://www.scielo.br/pohttps://old.scielo.br/oai/scielo-oai.php||revista@abpol.org.br1678-51690104-1428opendoar:2015-10-05T00:00Polímeros (São Carlos. Online) - Associação Brasileira de Polímeros (ABPol)false
dc.title.none.fl_str_mv Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
title Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
spellingShingle Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
Echeverría,María Gabriela
polyurethanes
drug delivery systems
stimuli-sensitive polymers
swelling
theophylline
title_short Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
title_full Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
title_fullStr Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
title_full_unstemmed Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
title_sort Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
author Echeverría,María Gabriela
author_facet Echeverría,María Gabriela
Pardini,Oscar Ricardo
Debandi,María Valeria
François,Nora Judit
Daraio,Marta Edith
Amalvy,Javier Ignacio
author_role author
author2 Pardini,Oscar Ricardo
Debandi,María Valeria
François,Nora Judit
Daraio,Marta Edith
Amalvy,Javier Ignacio
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Echeverría,María Gabriela
Pardini,Oscar Ricardo
Debandi,María Valeria
François,Nora Judit
Daraio,Marta Edith
Amalvy,Javier Ignacio
dc.subject.por.fl_str_mv polyurethanes
drug delivery systems
stimuli-sensitive polymers
swelling
theophylline
topic polyurethanes
drug delivery systems
stimuli-sensitive polymers
swelling
theophylline
description AbstractA pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film-forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity at different pHs. The drug release profile of films was evaluated using a vertical Franz Cell and theophylline as model drug. The water swelling degree increases from 54 to 180% when the pH of the medium is changed from 6 to 2, demonstrating the pH-responsive behavior of the film. The in-vitro release studies indicate that an anomalous transport mechanism governs the theophylline release.
publishDate 2015
dc.date.none.fl_str_mv 2015-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282015000400336
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282015000400336
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0104-1428.1716
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Polímeros
publisher.none.fl_str_mv Associação Brasileira de Polímeros
dc.source.none.fl_str_mv Polímeros v.25 n.4 2015
reponame:Polímeros (São Carlos. Online)
instname:Associação Brasileira de Polímeros (ABPol)
instacron:ABPO
instname_str Associação Brasileira de Polímeros (ABPol)
instacron_str ABPO
institution ABPO
reponame_str Polímeros (São Carlos. Online)
collection Polímeros (São Carlos. Online)
repository.name.fl_str_mv Polímeros (São Carlos. Online) - Associação Brasileira de Polímeros (ABPol)
repository.mail.fl_str_mv ||revista@abpol.org.br
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