Developing asthma in childhood from exposure to secondhand tobacco smoke: insights from a meta-regression
Autor(a) principal: | |
---|---|
Data de Publicação: | 2008 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Ciência & Saúde Coletiva (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232008000400028 |
Resumo: | Studies have shown links between household secondhand tobacco smoke (SHS) exposure and induction of childhood asthma. But the true nature of this link remains unclear in many studies. We conducted a meta-analysis of studies published from 1970 to 2005 to uncover consistent patterns of relative risk estimates (RRs), and found substantial heterogeneity within initial summary RRs of 1.48 [95% confidence interval (CI), 1.32-1.65], 1.25 (1.21-1.30), and 1.21 (1.08-1.36), for ever, current, and incident asthma, respectively. Lack of control for type of atopy history (familial or child) and child's own smoking status within studies and age category altered summary RRs in separate metaregressions. After adjustments, consistent patterns of association emerged between SHS exposure and childhood asthma induction. Our summary RR of 1.33 (95% CI, 1.14-1.56) from studies of incident asthma among older children (618 years old) is 1.27 times the estimate from studies of younger children and higher than estimates from earlier meta-analyses. This showns that exposure duration may be a more important factor than previously understood, and suggests that SHS could be a more fundamental cause of childhood asthma than some previous meta-analyses have indicated. |
id |
ABRASCO-2_43e0f966db5ca744ca66927c865cf40e |
---|---|
oai_identifier_str |
oai:scielo:S1413-81232008000400028 |
network_acronym_str |
ABRASCO-2 |
network_name_str |
Ciência & Saúde Coletiva (Online) |
repository_id_str |
|
spelling |
Developing asthma in childhood from exposure to secondhand tobacco smoke: insights from a meta-regressionChildhood asthmaEnvironmental tobacco smokeMeta-analysisMeta-regressionRelative riskSecondhand tobacco smokeStudies have shown links between household secondhand tobacco smoke (SHS) exposure and induction of childhood asthma. But the true nature of this link remains unclear in many studies. We conducted a meta-analysis of studies published from 1970 to 2005 to uncover consistent patterns of relative risk estimates (RRs), and found substantial heterogeneity within initial summary RRs of 1.48 [95% confidence interval (CI), 1.32-1.65], 1.25 (1.21-1.30), and 1.21 (1.08-1.36), for ever, current, and incident asthma, respectively. Lack of control for type of atopy history (familial or child) and child's own smoking status within studies and age category altered summary RRs in separate metaregressions. After adjustments, consistent patterns of association emerged between SHS exposure and childhood asthma induction. Our summary RR of 1.33 (95% CI, 1.14-1.56) from studies of incident asthma among older children (618 years old) is 1.27 times the estimate from studies of younger children and higher than estimates from earlier meta-analyses. This showns that exposure duration may be a more important factor than previously understood, and suggests that SHS could be a more fundamental cause of childhood asthma than some previous meta-analyses have indicated.ABRASCO - Associação Brasileira de Saúde Coletiva2008-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232008000400028Ciência & Saúde Coletiva v.13 n.4 2008reponame:Ciência & Saúde Coletiva (Online)instname:Associação Brasileira de Saúde Coletiva (ABRASCO)instacron:ABRASCO10.1590/S1413-81232008000400028info:eu-repo/semantics/openAccessVork,KathleenBroadwin,RachelBlaisdell,Roberteng2008-07-08T00:00:00Zoai:scielo:S1413-81232008000400028Revistahttp://www.cienciaesaudecoletiva.com.brhttps://old.scielo.br/oai/scielo-oai.php||cienciasaudecoletiva@fiocruz.br1678-45611413-8123opendoar:2008-07-08T00:00Ciência & Saúde Coletiva (Online) - Associação Brasileira de Saúde Coletiva (ABRASCO)false |
dc.title.none.fl_str_mv |
Developing asthma in childhood from exposure to secondhand tobacco smoke: insights from a meta-regression |
title |
Developing asthma in childhood from exposure to secondhand tobacco smoke: insights from a meta-regression |
spellingShingle |
Developing asthma in childhood from exposure to secondhand tobacco smoke: insights from a meta-regression Vork,Kathleen Childhood asthma Environmental tobacco smoke Meta-analysis Meta-regression Relative risk Secondhand tobacco smoke |
title_short |
Developing asthma in childhood from exposure to secondhand tobacco smoke: insights from a meta-regression |
title_full |
Developing asthma in childhood from exposure to secondhand tobacco smoke: insights from a meta-regression |
title_fullStr |
Developing asthma in childhood from exposure to secondhand tobacco smoke: insights from a meta-regression |
title_full_unstemmed |
Developing asthma in childhood from exposure to secondhand tobacco smoke: insights from a meta-regression |
title_sort |
Developing asthma in childhood from exposure to secondhand tobacco smoke: insights from a meta-regression |
author |
Vork,Kathleen |
author_facet |
Vork,Kathleen Broadwin,Rachel Blaisdell,Robert |
author_role |
author |
author2 |
Broadwin,Rachel Blaisdell,Robert |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Vork,Kathleen Broadwin,Rachel Blaisdell,Robert |
dc.subject.por.fl_str_mv |
Childhood asthma Environmental tobacco smoke Meta-analysis Meta-regression Relative risk Secondhand tobacco smoke |
topic |
Childhood asthma Environmental tobacco smoke Meta-analysis Meta-regression Relative risk Secondhand tobacco smoke |
description |
Studies have shown links between household secondhand tobacco smoke (SHS) exposure and induction of childhood asthma. But the true nature of this link remains unclear in many studies. We conducted a meta-analysis of studies published from 1970 to 2005 to uncover consistent patterns of relative risk estimates (RRs), and found substantial heterogeneity within initial summary RRs of 1.48 [95% confidence interval (CI), 1.32-1.65], 1.25 (1.21-1.30), and 1.21 (1.08-1.36), for ever, current, and incident asthma, respectively. Lack of control for type of atopy history (familial or child) and child's own smoking status within studies and age category altered summary RRs in separate metaregressions. After adjustments, consistent patterns of association emerged between SHS exposure and childhood asthma induction. Our summary RR of 1.33 (95% CI, 1.14-1.56) from studies of incident asthma among older children (618 years old) is 1.27 times the estimate from studies of younger children and higher than estimates from earlier meta-analyses. This showns that exposure duration may be a more important factor than previously understood, and suggests that SHS could be a more fundamental cause of childhood asthma than some previous meta-analyses have indicated. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232008000400028 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232008000400028 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1413-81232008000400028 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
ABRASCO - Associação Brasileira de Saúde Coletiva |
publisher.none.fl_str_mv |
ABRASCO - Associação Brasileira de Saúde Coletiva |
dc.source.none.fl_str_mv |
Ciência & Saúde Coletiva v.13 n.4 2008 reponame:Ciência & Saúde Coletiva (Online) instname:Associação Brasileira de Saúde Coletiva (ABRASCO) instacron:ABRASCO |
instname_str |
Associação Brasileira de Saúde Coletiva (ABRASCO) |
instacron_str |
ABRASCO |
institution |
ABRASCO |
reponame_str |
Ciência & Saúde Coletiva (Online) |
collection |
Ciência & Saúde Coletiva (Online) |
repository.name.fl_str_mv |
Ciência & Saúde Coletiva (Online) - Associação Brasileira de Saúde Coletiva (ABRASCO) |
repository.mail.fl_str_mv |
||cienciasaudecoletiva@fiocruz.br |
_version_ |
1754213027120414720 |