Evaluation of KI-67 expression in uterine leiomyoma and in healthy myometrium: a pilot study

• Autor(a) principal: Eulálio Filho,Walberto Monteiro Neiva
• Data de Publicação: 2019
• Outros Autores: Soares,Eduardo Augusto Sousa, Lima,Maria Simone Oliveira, Brazil,Emerson Davi do Nascimento, Rodrigues,Rodolfo Myronn de Melo, Zeron,Rubens Moura Campos, Silva,Benedito Borges, Costa,Pedro Vitor Lopes
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista da Associação Médica Brasileira (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019001201459
• topic: Ki-67 Antigen; Leiomyoma; Myometrium

SUMMARY OBJECTIVE Evaluate the expression of KI-67 in uterine leiomyomas and adjacent myometrial tissue and verify the existence of a correlation between clinical parameters and KI-67 expression in tumors. METHODS This is a cross-sectional, controlled, analytical study. Samples of leiomyomas and myometrium were obtained from patients who underwent hysterectomy. The samples were processed by immunohistochemistry using KI-67 antibody, and the expression was evaluated by two blinded observers. Student›s T-test was used for comparison of means, and Pearson›s P test for correlation with clinical parameters. RESULTS A total of 9 patients were included in the study. The mean age was 40.7 years, ranging from 35 to 44 years. The mean expression of KI-67 in myometrium was 1.63%, and, in leiomyomas, 5.96% (p <0.001). The highest expression of KI-67 was moderately related to the severity of anemia, bleeding, and pain level. CONCLUSION The expression of KI-67 in normal myometrium was significantly lower than in leiomyomas. The highest expression of KI-67 was moderately related to the severity of anemia, bleeding, and pain level in the patients of this study.