Anthracycline-associated cardiotoxicity in adults: systematic review on the cardioprotective role of beta-blockers
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Associação Médica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302018000800745 |
Resumo: | SUMMARY OBJECTIVES This study aimed at assessing the role of beta-blockers on preventing anthracycline-induced cardiotoxicity in adults. METHODS A systematic review was performed on electronic databases, including relevant studies that analysed beta-blockers as cardioprotective agents before the use of anthracyclines by adult oncologic patients. RESULTS After application of eligibility and selection criteria, eight articles were considered as high quality, complying with the proposed theme; all eight clinical trials, four of them placebo-controlled, with a total number of 655 patients included. From this sample, 281 (42.9%) used beta-blocker as intervention, and carvedilol was the most frequent (167 patients – 25.5%). Six studies were considered positive regarding the cardioprotection role played by beta-blockers, although only four demonstrated significant difference on left ventricle ejection fraction after chemotherapy on groups that used beta-blockers compared to control groups. Carvedilol and nebivolol, but not metoprolol, had positive results regarding cardioprotection. Other beta-blockers were not analysed in the selected studies. CONCLUSIONS Despite the potential cardioprotective effect of beta-blockers, as demonstrated in small and unicentric clinical trials, its routine use on prevention of anthracycline-associated cardiotoxicity demands greater scientific evidence. |
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Anthracycline-associated cardiotoxicity in adults: systematic review on the cardioprotective role of beta-blockersCardiotoxicityAnthracyclinesHeart failureHeart diseases/prevention & controlSUMMARY OBJECTIVES This study aimed at assessing the role of beta-blockers on preventing anthracycline-induced cardiotoxicity in adults. METHODS A systematic review was performed on electronic databases, including relevant studies that analysed beta-blockers as cardioprotective agents before the use of anthracyclines by adult oncologic patients. RESULTS After application of eligibility and selection criteria, eight articles were considered as high quality, complying with the proposed theme; all eight clinical trials, four of them placebo-controlled, with a total number of 655 patients included. From this sample, 281 (42.9%) used beta-blocker as intervention, and carvedilol was the most frequent (167 patients – 25.5%). Six studies were considered positive regarding the cardioprotection role played by beta-blockers, although only four demonstrated significant difference on left ventricle ejection fraction after chemotherapy on groups that used beta-blockers compared to control groups. Carvedilol and nebivolol, but not metoprolol, had positive results regarding cardioprotection. Other beta-blockers were not analysed in the selected studies. CONCLUSIONS Despite the potential cardioprotective effect of beta-blockers, as demonstrated in small and unicentric clinical trials, its routine use on prevention of anthracycline-associated cardiotoxicity demands greater scientific evidence.Associação Médica Brasileira2018-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302018000800745Revista da Associação Médica Brasileira v.64 n.8 2018reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.64.08.745info:eu-repo/semantics/openAccessBarbosa,Roberto RamosBourguignon,Taissa BorgesTorres,Luíza DiasArruda,Lorenza SilveiraJacques,Tiago de MeloSerpa,Renato GiestasCalil,Osmar de AraujoBarbosa,Luiz Fernando Machadoeng2019-03-14T00:00:00Zoai:scielo:S0104-42302018000800745Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2019-03-14T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
Anthracycline-associated cardiotoxicity in adults: systematic review on the cardioprotective role of beta-blockers |
title |
Anthracycline-associated cardiotoxicity in adults: systematic review on the cardioprotective role of beta-blockers |
spellingShingle |
Anthracycline-associated cardiotoxicity in adults: systematic review on the cardioprotective role of beta-blockers Barbosa,Roberto Ramos Cardiotoxicity Anthracyclines Heart failure Heart diseases/prevention & control |
title_short |
Anthracycline-associated cardiotoxicity in adults: systematic review on the cardioprotective role of beta-blockers |
title_full |
Anthracycline-associated cardiotoxicity in adults: systematic review on the cardioprotective role of beta-blockers |
title_fullStr |
Anthracycline-associated cardiotoxicity in adults: systematic review on the cardioprotective role of beta-blockers |
title_full_unstemmed |
Anthracycline-associated cardiotoxicity in adults: systematic review on the cardioprotective role of beta-blockers |
title_sort |
Anthracycline-associated cardiotoxicity in adults: systematic review on the cardioprotective role of beta-blockers |
author |
Barbosa,Roberto Ramos |
author_facet |
Barbosa,Roberto Ramos Bourguignon,Taissa Borges Torres,Luíza Dias Arruda,Lorenza Silveira Jacques,Tiago de Melo Serpa,Renato Giestas Calil,Osmar de Araujo Barbosa,Luiz Fernando Machado |
author_role |
author |
author2 |
Bourguignon,Taissa Borges Torres,Luíza Dias Arruda,Lorenza Silveira Jacques,Tiago de Melo Serpa,Renato Giestas Calil,Osmar de Araujo Barbosa,Luiz Fernando Machado |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Barbosa,Roberto Ramos Bourguignon,Taissa Borges Torres,Luíza Dias Arruda,Lorenza Silveira Jacques,Tiago de Melo Serpa,Renato Giestas Calil,Osmar de Araujo Barbosa,Luiz Fernando Machado |
dc.subject.por.fl_str_mv |
Cardiotoxicity Anthracyclines Heart failure Heart diseases/prevention & control |
topic |
Cardiotoxicity Anthracyclines Heart failure Heart diseases/prevention & control |
description |
SUMMARY OBJECTIVES This study aimed at assessing the role of beta-blockers on preventing anthracycline-induced cardiotoxicity in adults. METHODS A systematic review was performed on electronic databases, including relevant studies that analysed beta-blockers as cardioprotective agents before the use of anthracyclines by adult oncologic patients. RESULTS After application of eligibility and selection criteria, eight articles were considered as high quality, complying with the proposed theme; all eight clinical trials, four of them placebo-controlled, with a total number of 655 patients included. From this sample, 281 (42.9%) used beta-blocker as intervention, and carvedilol was the most frequent (167 patients – 25.5%). Six studies were considered positive regarding the cardioprotection role played by beta-blockers, although only four demonstrated significant difference on left ventricle ejection fraction after chemotherapy on groups that used beta-blockers compared to control groups. Carvedilol and nebivolol, but not metoprolol, had positive results regarding cardioprotection. Other beta-blockers were not analysed in the selected studies. CONCLUSIONS Despite the potential cardioprotective effect of beta-blockers, as demonstrated in small and unicentric clinical trials, its routine use on prevention of anthracycline-associated cardiotoxicity demands greater scientific evidence. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302018000800745 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302018000800745 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-9282.64.08.745 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
publisher.none.fl_str_mv |
Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.64 n.8 2018 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
instname_str |
Associação Médica Brasileira (AMB) |
instacron_str |
AMB |
institution |
AMB |
reponame_str |
Revista da Associação Médica Brasileira (Online) |
collection |
Revista da Associação Médica Brasileira (Online) |
repository.name.fl_str_mv |
Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
repository.mail.fl_str_mv |
||ramb@amb.org.br |
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1754212833452621824 |