Characterization of the first symptoms of multiple sclerosis in a Brazilian center: cross-sectional study
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | São Paulo medical journal (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802017000300222 |
Resumo: | ABSTRACT CONTEXT AND OBJECTIVE: Multiple sclerosis (MS) is a chronic, immune-mediated and degenerative central nervous system (CNS) disease with well-established diagnostic criteria. Treatment can modify the course of the disease. The objective of this study was to describe the initial symptoms of multiple sclerosis in a Brazilian medical center. DESIGN AND SETTING: Descriptive study, conducted in a Brazilian reference center for multiple sclerosis treatment. METHODS: Data on 299 patients with confirmed diagnoses of MS were included in the study. Their medical files were evaluated and the data were analyzed. RESULTS: The most common symptom involved the cranial nerves (50.83%) and unifocal manifestation was presented by the majority of this population (73.91%). The mean time between the first symptom and the diagnosis was 2.84 years. Unifocal symptoms correlated with longer time taken to establish the diagnosis, with an average of 3.20 years, while for multifocal symptoms the average time taken for the diagnosis was 1.85 years. Unifocal onset was related to greater diagnostic difficulty. CONCLUSIONS: MS is a heterogeneous disease and its initial clinical manifestation is very variable. |
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São Paulo medical journal (Online) |
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Characterization of the first symptoms of multiple sclerosis in a Brazilian center: cross-sectional studyMultiple sclerosisAcademic medical centersSymptom assessmentIllness behaviorCranial nervesABSTRACT CONTEXT AND OBJECTIVE: Multiple sclerosis (MS) is a chronic, immune-mediated and degenerative central nervous system (CNS) disease with well-established diagnostic criteria. Treatment can modify the course of the disease. The objective of this study was to describe the initial symptoms of multiple sclerosis in a Brazilian medical center. DESIGN AND SETTING: Descriptive study, conducted in a Brazilian reference center for multiple sclerosis treatment. METHODS: Data on 299 patients with confirmed diagnoses of MS were included in the study. Their medical files were evaluated and the data were analyzed. RESULTS: The most common symptom involved the cranial nerves (50.83%) and unifocal manifestation was presented by the majority of this population (73.91%). The mean time between the first symptom and the diagnosis was 2.84 years. Unifocal symptoms correlated with longer time taken to establish the diagnosis, with an average of 3.20 years, while for multifocal symptoms the average time taken for the diagnosis was 1.85 years. Unifocal onset was related to greater diagnostic difficulty. CONCLUSIONS: MS is a heterogeneous disease and its initial clinical manifestation is very variable.Associação Paulista de Medicina - APM2017-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802017000300222Sao Paulo Medical Journal v.135 n.3 2017reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/1516-3180.2016.0200270117info:eu-repo/semantics/openAccessCavenaghi,Vitor BreseghelloDobrianskyj,Fernanda MartinhoOlival,Guilherme Sciascia doCarneiro,Rafael Paternò Castello DiasTilbery,Charles Petereng2017-07-20T00:00:00Zoai:scielo:S1516-31802017000300222Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2017-07-20T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse |
dc.title.none.fl_str_mv |
Characterization of the first symptoms of multiple sclerosis in a Brazilian center: cross-sectional study |
title |
Characterization of the first symptoms of multiple sclerosis in a Brazilian center: cross-sectional study |
spellingShingle |
Characterization of the first symptoms of multiple sclerosis in a Brazilian center: cross-sectional study Cavenaghi,Vitor Breseghello Multiple sclerosis Academic medical centers Symptom assessment Illness behavior Cranial nerves |
title_short |
Characterization of the first symptoms of multiple sclerosis in a Brazilian center: cross-sectional study |
title_full |
Characterization of the first symptoms of multiple sclerosis in a Brazilian center: cross-sectional study |
title_fullStr |
Characterization of the first symptoms of multiple sclerosis in a Brazilian center: cross-sectional study |
title_full_unstemmed |
Characterization of the first symptoms of multiple sclerosis in a Brazilian center: cross-sectional study |
title_sort |
Characterization of the first symptoms of multiple sclerosis in a Brazilian center: cross-sectional study |
author |
Cavenaghi,Vitor Breseghello |
author_facet |
Cavenaghi,Vitor Breseghello Dobrianskyj,Fernanda Martinho Olival,Guilherme Sciascia do Carneiro,Rafael Paternò Castello Dias Tilbery,Charles Peter |
author_role |
author |
author2 |
Dobrianskyj,Fernanda Martinho Olival,Guilherme Sciascia do Carneiro,Rafael Paternò Castello Dias Tilbery,Charles Peter |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Cavenaghi,Vitor Breseghello Dobrianskyj,Fernanda Martinho Olival,Guilherme Sciascia do Carneiro,Rafael Paternò Castello Dias Tilbery,Charles Peter |
dc.subject.por.fl_str_mv |
Multiple sclerosis Academic medical centers Symptom assessment Illness behavior Cranial nerves |
topic |
Multiple sclerosis Academic medical centers Symptom assessment Illness behavior Cranial nerves |
description |
ABSTRACT CONTEXT AND OBJECTIVE: Multiple sclerosis (MS) is a chronic, immune-mediated and degenerative central nervous system (CNS) disease with well-established diagnostic criteria. Treatment can modify the course of the disease. The objective of this study was to describe the initial symptoms of multiple sclerosis in a Brazilian medical center. DESIGN AND SETTING: Descriptive study, conducted in a Brazilian reference center for multiple sclerosis treatment. METHODS: Data on 299 patients with confirmed diagnoses of MS were included in the study. Their medical files were evaluated and the data were analyzed. RESULTS: The most common symptom involved the cranial nerves (50.83%) and unifocal manifestation was presented by the majority of this population (73.91%). The mean time between the first symptom and the diagnosis was 2.84 years. Unifocal symptoms correlated with longer time taken to establish the diagnosis, with an average of 3.20 years, while for multifocal symptoms the average time taken for the diagnosis was 1.85 years. Unifocal onset was related to greater diagnostic difficulty. CONCLUSIONS: MS is a heterogeneous disease and its initial clinical manifestation is very variable. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802017000300222 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802017000300222 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1516-3180.2016.0200270117 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
dc.source.none.fl_str_mv |
Sao Paulo Medical Journal v.135 n.3 2017 reponame:São Paulo medical journal (Online) instname:Associação Paulista de Medicina instacron:APM |
instname_str |
Associação Paulista de Medicina |
instacron_str |
APM |
institution |
APM |
reponame_str |
São Paulo medical journal (Online) |
collection |
São Paulo medical journal (Online) |
repository.name.fl_str_mv |
São Paulo medical journal (Online) - Associação Paulista de Medicina |
repository.mail.fl_str_mv |
revistas@apm.org.br |
_version_ |
1754209265337237504 |