Evidence of association between the use of drugs and community-dwelling older people frailty: a cross-sectional study
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | São Paulo medical journal (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802020000600465 |
Resumo: | ABSTRACT BACKGROUND: The scientific literature has shown that an association between polypharmacy and frailty exists. However, few studies have also considered drug interactions and the use of potentially inappropriate medications. OBJECTIVE: To evaluate the association between the use of drugs and frailty among community-dwelling older people. DESIGN AND SETTING: Cross-sectional study carried out among 580 older people in Uberaba (MG). METHODS: Data were collected at these older people's homes using instruments validated in Brazil. Descriptive, bivariate and binary logistic regression analyses were performed (P < 0.05). RESULTS: Most of these individuals were classified as pre-frail (55.7%), while 13.1% were frail. It was found that 31.7% of them presented polypharmacy, 41.7% had drug interactions and 43.8% were using potentially inappropriate medications. In the initial model, polypharmacy (odds ratio, OR = 1.91; confidence interval, CI = 1.27-2.86) and use of potentially inappropriate medications (OR = 2.45; CI = 1.68-3.57) increased the chance that these older people would be pre-frail or frail. In the final adjusted model, use of potentially inappropriate drugs remained associated with the outcome (OR = 2.26; CI = 1.43-3.57). CONCLUSION: Use of potentially inappropriate medications was the independent variable that explained the occurrence of frailty in a representative sample of community-dwelling older adults. |
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Evidence of association between the use of drugs and community-dwelling older people frailty: a cross-sectional studyPolypharmacyDrug interactionsPotentially inappropriate medication listOlder peopleFrail older peoplePolypharmacy among older peopleABSTRACT BACKGROUND: The scientific literature has shown that an association between polypharmacy and frailty exists. However, few studies have also considered drug interactions and the use of potentially inappropriate medications. OBJECTIVE: To evaluate the association between the use of drugs and frailty among community-dwelling older people. DESIGN AND SETTING: Cross-sectional study carried out among 580 older people in Uberaba (MG). METHODS: Data were collected at these older people's homes using instruments validated in Brazil. Descriptive, bivariate and binary logistic regression analyses were performed (P < 0.05). RESULTS: Most of these individuals were classified as pre-frail (55.7%), while 13.1% were frail. It was found that 31.7% of them presented polypharmacy, 41.7% had drug interactions and 43.8% were using potentially inappropriate medications. In the initial model, polypharmacy (odds ratio, OR = 1.91; confidence interval, CI = 1.27-2.86) and use of potentially inappropriate medications (OR = 2.45; CI = 1.68-3.57) increased the chance that these older people would be pre-frail or frail. In the final adjusted model, use of potentially inappropriate drugs remained associated with the outcome (OR = 2.26; CI = 1.43-3.57). CONCLUSION: Use of potentially inappropriate medications was the independent variable that explained the occurrence of frailty in a representative sample of community-dwelling older adults.Associação Paulista de Medicina - APM2020-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802020000600465Sao Paulo Medical Journal v.138 n.6 2020reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/1516-3180.2020.0205.r1.06082020info:eu-repo/semantics/openAccessAlves,Marcos Kaic LopesOliveira,Nayara Gomes NunesPegorari,Maycon SousaTavares,Darlene Mara dos SantosRodrigues,Maria Cristina SoaresBolina,Alisson Fernandeseng2020-12-17T00:00:00Zoai:scielo:S1516-31802020000600465Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2020-12-17T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse |
dc.title.none.fl_str_mv |
Evidence of association between the use of drugs and community-dwelling older people frailty: a cross-sectional study |
title |
Evidence of association between the use of drugs and community-dwelling older people frailty: a cross-sectional study |
spellingShingle |
Evidence of association between the use of drugs and community-dwelling older people frailty: a cross-sectional study Alves,Marcos Kaic Lopes Polypharmacy Drug interactions Potentially inappropriate medication list Older people Frail older people Polypharmacy among older people |
title_short |
Evidence of association between the use of drugs and community-dwelling older people frailty: a cross-sectional study |
title_full |
Evidence of association between the use of drugs and community-dwelling older people frailty: a cross-sectional study |
title_fullStr |
Evidence of association between the use of drugs and community-dwelling older people frailty: a cross-sectional study |
title_full_unstemmed |
Evidence of association between the use of drugs and community-dwelling older people frailty: a cross-sectional study |
title_sort |
Evidence of association between the use of drugs and community-dwelling older people frailty: a cross-sectional study |
author |
Alves,Marcos Kaic Lopes |
author_facet |
Alves,Marcos Kaic Lopes Oliveira,Nayara Gomes Nunes Pegorari,Maycon Sousa Tavares,Darlene Mara dos Santos Rodrigues,Maria Cristina Soares Bolina,Alisson Fernandes |
author_role |
author |
author2 |
Oliveira,Nayara Gomes Nunes Pegorari,Maycon Sousa Tavares,Darlene Mara dos Santos Rodrigues,Maria Cristina Soares Bolina,Alisson Fernandes |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Alves,Marcos Kaic Lopes Oliveira,Nayara Gomes Nunes Pegorari,Maycon Sousa Tavares,Darlene Mara dos Santos Rodrigues,Maria Cristina Soares Bolina,Alisson Fernandes |
dc.subject.por.fl_str_mv |
Polypharmacy Drug interactions Potentially inappropriate medication list Older people Frail older people Polypharmacy among older people |
topic |
Polypharmacy Drug interactions Potentially inappropriate medication list Older people Frail older people Polypharmacy among older people |
description |
ABSTRACT BACKGROUND: The scientific literature has shown that an association between polypharmacy and frailty exists. However, few studies have also considered drug interactions and the use of potentially inappropriate medications. OBJECTIVE: To evaluate the association between the use of drugs and frailty among community-dwelling older people. DESIGN AND SETTING: Cross-sectional study carried out among 580 older people in Uberaba (MG). METHODS: Data were collected at these older people's homes using instruments validated in Brazil. Descriptive, bivariate and binary logistic regression analyses were performed (P < 0.05). RESULTS: Most of these individuals were classified as pre-frail (55.7%), while 13.1% were frail. It was found that 31.7% of them presented polypharmacy, 41.7% had drug interactions and 43.8% were using potentially inappropriate medications. In the initial model, polypharmacy (odds ratio, OR = 1.91; confidence interval, CI = 1.27-2.86) and use of potentially inappropriate medications (OR = 2.45; CI = 1.68-3.57) increased the chance that these older people would be pre-frail or frail. In the final adjusted model, use of potentially inappropriate drugs remained associated with the outcome (OR = 2.26; CI = 1.43-3.57). CONCLUSION: Use of potentially inappropriate medications was the independent variable that explained the occurrence of frailty in a representative sample of community-dwelling older adults. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802020000600465 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802020000600465 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1516-3180.2020.0205.r1.06082020 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
dc.source.none.fl_str_mv |
Sao Paulo Medical Journal v.138 n.6 2020 reponame:São Paulo medical journal (Online) instname:Associação Paulista de Medicina instacron:APM |
instname_str |
Associação Paulista de Medicina |
instacron_str |
APM |
institution |
APM |
reponame_str |
São Paulo medical journal (Online) |
collection |
São Paulo medical journal (Online) |
repository.name.fl_str_mv |
São Paulo medical journal (Online) - Associação Paulista de Medicina |
repository.mail.fl_str_mv |
revistas@apm.org.br |
_version_ |
1754209267249840128 |