Clinical and familial profile of bipolar disorder with and without obsessive-compulsive disorder: an Indian study
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Trends in Psychiatry and Psychotherapy |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-60892017000400270 |
Resumo: | Abstract Introduction Comorbid obsessive-compulsive disorder (OCD) is common in bipolar disorder (BD). Clinical characteristics, functionality and familial pattern of this comorbidity are largely understudied. Objective To assess clinical profile, familial loading of psychiatric disorders and level of functioning in remitted BD patients who have comorbid OCD and to compare results with those of remitted BD patients without OCD. Methods Remitted BD-I subjects were assessed using the Structured Clinical Interview for DSM-IV Axis I Disorders, Global Assessment of Functioning Scale (GAF), Hamilton Depression Rating Scale (HDRS), Young Mania Rating Scale (YMRS), Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and Family Interview for Genetic Studies (FIGS). BD patients with and without OCD were compared. Group differences were analyzed using the chi-square test and the independent samples t test. Values <0.05 were considered statistically significant. Results Of the 90 remitted BD-I patients, 35.5% (n=32) had obsessive-compulsive symptoms/OCD. The BD-OCD group showed significantly lower GAF scores, higher rates of suicidal attempts, hospitalizations, manic and depressive episodes compared to the group with BD only (p<0.05). In addition, first and second-degree relatives had higher rates of BD-OCD and OCD, but not of BD. Conclusions BD-OCD is characterized by more severe BD, more dysfunction and higher familial loading of BD-OCD and OCD. Larger studies involving relatives of probands will help to confirm our findings and to delineate nosological status of BD-OCD comorbidity. |
id |
APRGS-1_da66da93b5eb43620eaa91f6e509b84d |
---|---|
oai_identifier_str |
oai:scielo:S2237-60892017000400270 |
network_acronym_str |
APRGS-1 |
network_name_str |
Trends in Psychiatry and Psychotherapy |
repository_id_str |
|
spelling |
Clinical and familial profile of bipolar disorder with and without obsessive-compulsive disorder: an Indian studyBipolar disordercomorbidityfamilial loadingobsessive-compulsive disorderAbstract Introduction Comorbid obsessive-compulsive disorder (OCD) is common in bipolar disorder (BD). Clinical characteristics, functionality and familial pattern of this comorbidity are largely understudied. Objective To assess clinical profile, familial loading of psychiatric disorders and level of functioning in remitted BD patients who have comorbid OCD and to compare results with those of remitted BD patients without OCD. Methods Remitted BD-I subjects were assessed using the Structured Clinical Interview for DSM-IV Axis I Disorders, Global Assessment of Functioning Scale (GAF), Hamilton Depression Rating Scale (HDRS), Young Mania Rating Scale (YMRS), Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and Family Interview for Genetic Studies (FIGS). BD patients with and without OCD were compared. Group differences were analyzed using the chi-square test and the independent samples t test. Values <0.05 were considered statistically significant. Results Of the 90 remitted BD-I patients, 35.5% (n=32) had obsessive-compulsive symptoms/OCD. The BD-OCD group showed significantly lower GAF scores, higher rates of suicidal attempts, hospitalizations, manic and depressive episodes compared to the group with BD only (p<0.05). In addition, first and second-degree relatives had higher rates of BD-OCD and OCD, but not of BD. Conclusions BD-OCD is characterized by more severe BD, more dysfunction and higher familial loading of BD-OCD and OCD. Larger studies involving relatives of probands will help to confirm our findings and to delineate nosological status of BD-OCD comorbidity.Associação de Psiquiatria do Rio Grande do Sul2017-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-60892017000400270Trends in Psychiatry and Psychotherapy v.39 n.4 2017reponame:Trends in Psychiatry and Psychotherapyinstname:Sociedade de Psiquiatria do Rio Grande do Sulinstacron:APRGS10.1590/2237-6089-2017-0061info:eu-repo/semantics/openAccessKazhungil,FirozCholakottil,AjithaKattukulathil,ShihabKottelassal,AbdurazakVazhakalayil,Rajeesheng2017-12-20T00:00:00Zoai:scielo:S2237-60892017000400270Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=2237-6089&lng=en&nrm=isohttps://old.scielo.br/oai/scielo-oai.phprevista@aprs.org.br|| rodrigo_grassi@terra.com.br2238-00192237-6089opendoar:2017-12-20T00:00Trends in Psychiatry and Psychotherapy - Sociedade de Psiquiatria do Rio Grande do Sulfalse |
dc.title.none.fl_str_mv |
Clinical and familial profile of bipolar disorder with and without obsessive-compulsive disorder: an Indian study |
title |
Clinical and familial profile of bipolar disorder with and without obsessive-compulsive disorder: an Indian study |
spellingShingle |
Clinical and familial profile of bipolar disorder with and without obsessive-compulsive disorder: an Indian study Kazhungil,Firoz Bipolar disorder comorbidity familial loading obsessive-compulsive disorder |
title_short |
Clinical and familial profile of bipolar disorder with and without obsessive-compulsive disorder: an Indian study |
title_full |
Clinical and familial profile of bipolar disorder with and without obsessive-compulsive disorder: an Indian study |
title_fullStr |
Clinical and familial profile of bipolar disorder with and without obsessive-compulsive disorder: an Indian study |
title_full_unstemmed |
Clinical and familial profile of bipolar disorder with and without obsessive-compulsive disorder: an Indian study |
title_sort |
Clinical and familial profile of bipolar disorder with and without obsessive-compulsive disorder: an Indian study |
author |
Kazhungil,Firoz |
author_facet |
Kazhungil,Firoz Cholakottil,Ajitha Kattukulathil,Shihab Kottelassal,Abdurazak Vazhakalayil,Rajeesh |
author_role |
author |
author2 |
Cholakottil,Ajitha Kattukulathil,Shihab Kottelassal,Abdurazak Vazhakalayil,Rajeesh |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Kazhungil,Firoz Cholakottil,Ajitha Kattukulathil,Shihab Kottelassal,Abdurazak Vazhakalayil,Rajeesh |
dc.subject.por.fl_str_mv |
Bipolar disorder comorbidity familial loading obsessive-compulsive disorder |
topic |
Bipolar disorder comorbidity familial loading obsessive-compulsive disorder |
description |
Abstract Introduction Comorbid obsessive-compulsive disorder (OCD) is common in bipolar disorder (BD). Clinical characteristics, functionality and familial pattern of this comorbidity are largely understudied. Objective To assess clinical profile, familial loading of psychiatric disorders and level of functioning in remitted BD patients who have comorbid OCD and to compare results with those of remitted BD patients without OCD. Methods Remitted BD-I subjects were assessed using the Structured Clinical Interview for DSM-IV Axis I Disorders, Global Assessment of Functioning Scale (GAF), Hamilton Depression Rating Scale (HDRS), Young Mania Rating Scale (YMRS), Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and Family Interview for Genetic Studies (FIGS). BD patients with and without OCD were compared. Group differences were analyzed using the chi-square test and the independent samples t test. Values <0.05 were considered statistically significant. Results Of the 90 remitted BD-I patients, 35.5% (n=32) had obsessive-compulsive symptoms/OCD. The BD-OCD group showed significantly lower GAF scores, higher rates of suicidal attempts, hospitalizations, manic and depressive episodes compared to the group with BD only (p<0.05). In addition, first and second-degree relatives had higher rates of BD-OCD and OCD, but not of BD. Conclusions BD-OCD is characterized by more severe BD, more dysfunction and higher familial loading of BD-OCD and OCD. Larger studies involving relatives of probands will help to confirm our findings and to delineate nosological status of BD-OCD comorbidity. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-60892017000400270 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-60892017000400270 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/2237-6089-2017-0061 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação de Psiquiatria do Rio Grande do Sul |
publisher.none.fl_str_mv |
Associação de Psiquiatria do Rio Grande do Sul |
dc.source.none.fl_str_mv |
Trends in Psychiatry and Psychotherapy v.39 n.4 2017 reponame:Trends in Psychiatry and Psychotherapy instname:Sociedade de Psiquiatria do Rio Grande do Sul instacron:APRGS |
instname_str |
Sociedade de Psiquiatria do Rio Grande do Sul |
instacron_str |
APRGS |
institution |
APRGS |
reponame_str |
Trends in Psychiatry and Psychotherapy |
collection |
Trends in Psychiatry and Psychotherapy |
repository.name.fl_str_mv |
Trends in Psychiatry and Psychotherapy - Sociedade de Psiquiatria do Rio Grande do Sul |
repository.mail.fl_str_mv |
revista@aprs.org.br|| rodrigo_grassi@terra.com.br |
_version_ |
1754209280998768640 |