Human herpesvirus 6A active infection in patients with autoimmune Hashimoto's thyroiditis
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Infectious Diseases |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600435 |
Resumo: | ABSTRACT Background: Hypothyroidism due to Hashimoto's thyroiditis (HT) is the commonest autoimmune endocrine illness in which antibodies against thyroid organ result in inflammation. The disease has a complex etiology that involves genetic and environmental influences. Viral infections may be involved in triggering of the disease as their molecular mimicry enhance autoimmune responses. Human herpesvirus-6 (HHV-6) is recognized for its contribution to some autoimmune diseases. Objective: In the current study, the prevalence of HHV-6 active infection in patients with HT and with non-autoimmune thyroid disorders were compared with patients with euthyroidism. In addition, a correlation between presence of HHV-6 infections and HT was investigated. Methods: A total of 151 patients with clinically and laboratory confirmed HT, 59 patients with non-autoimmune thyroid disorders, and 32 patients with normal thyroid function were included in the study. For further confirmation of HT disease, all the precipitants were tested for anti-thyroid peroxidase (TPO), and anti-thyroglobulin (TG) antibodies. For detection of both HHV-6 types A and B, nested PCR and restriction enzyme digestion were used. HHV-6 DNA positive samples were further investigated by DNA sequencing analysis. Results: HHV-6A DNA was found in serum sample of 57 out of 151 patients (38%) with HT, which was significantly more often than in patients with non-autoimmune thyroid disorders (p = 0.001). However, HHV-6 DNA was not detected in serum samples of euthyroid subjects. Conclusions: The results support a possible role for active HHV-6A infection, demonstrated by the presence of HHV-6 DNA in sera, in the development of HT. |
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Brazilian Journal of Infectious Diseases |
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Human herpesvirus 6A active infection in patients with autoimmune Hashimoto's thyroiditisHuman herpesvirus 6PrevalenceHashimoto diseaseAutoimmune diseasesABSTRACT Background: Hypothyroidism due to Hashimoto's thyroiditis (HT) is the commonest autoimmune endocrine illness in which antibodies against thyroid organ result in inflammation. The disease has a complex etiology that involves genetic and environmental influences. Viral infections may be involved in triggering of the disease as their molecular mimicry enhance autoimmune responses. Human herpesvirus-6 (HHV-6) is recognized for its contribution to some autoimmune diseases. Objective: In the current study, the prevalence of HHV-6 active infection in patients with HT and with non-autoimmune thyroid disorders were compared with patients with euthyroidism. In addition, a correlation between presence of HHV-6 infections and HT was investigated. Methods: A total of 151 patients with clinically and laboratory confirmed HT, 59 patients with non-autoimmune thyroid disorders, and 32 patients with normal thyroid function were included in the study. For further confirmation of HT disease, all the precipitants were tested for anti-thyroid peroxidase (TPO), and anti-thyroglobulin (TG) antibodies. For detection of both HHV-6 types A and B, nested PCR and restriction enzyme digestion were used. HHV-6 DNA positive samples were further investigated by DNA sequencing analysis. Results: HHV-6A DNA was found in serum sample of 57 out of 151 patients (38%) with HT, which was significantly more often than in patients with non-autoimmune thyroid disorders (p = 0.001). However, HHV-6 DNA was not detected in serum samples of euthyroid subjects. Conclusions: The results support a possible role for active HHV-6A infection, demonstrated by the presence of HHV-6 DNA in sera, in the development of HT.Brazilian Society of Infectious Diseases2019-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600435Brazilian Journal of Infectious Diseases v.23 n.6 2019reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1016/j.bjid.2019.10.004info:eu-repo/semantics/openAccessSeyyedi,NoorossadatDehbidi,Gholamreza RafieiKarimi,MozhganAsgari,AmirEsmaeili,BabakZare,FarahnazFarhadi,AliDabbaghmanesh,Mohammad HosseinSaki,ForoughBehzad-Behbahani,Abbaseng2020-02-10T00:00:00Zoai:scielo:S1413-86702019000600435Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2020-02-10T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false |
dc.title.none.fl_str_mv |
Human herpesvirus 6A active infection in patients with autoimmune Hashimoto's thyroiditis |
title |
Human herpesvirus 6A active infection in patients with autoimmune Hashimoto's thyroiditis |
spellingShingle |
Human herpesvirus 6A active infection in patients with autoimmune Hashimoto's thyroiditis Seyyedi,Noorossadat Human herpesvirus 6 Prevalence Hashimoto disease Autoimmune diseases |
title_short |
Human herpesvirus 6A active infection in patients with autoimmune Hashimoto's thyroiditis |
title_full |
Human herpesvirus 6A active infection in patients with autoimmune Hashimoto's thyroiditis |
title_fullStr |
Human herpesvirus 6A active infection in patients with autoimmune Hashimoto's thyroiditis |
title_full_unstemmed |
Human herpesvirus 6A active infection in patients with autoimmune Hashimoto's thyroiditis |
title_sort |
Human herpesvirus 6A active infection in patients with autoimmune Hashimoto's thyroiditis |
author |
Seyyedi,Noorossadat |
author_facet |
Seyyedi,Noorossadat Dehbidi,Gholamreza Rafiei Karimi,Mozhgan Asgari,Amir Esmaeili,Babak Zare,Farahnaz Farhadi,Ali Dabbaghmanesh,Mohammad Hossein Saki,Forough Behzad-Behbahani,Abbas |
author_role |
author |
author2 |
Dehbidi,Gholamreza Rafiei Karimi,Mozhgan Asgari,Amir Esmaeili,Babak Zare,Farahnaz Farhadi,Ali Dabbaghmanesh,Mohammad Hossein Saki,Forough Behzad-Behbahani,Abbas |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Seyyedi,Noorossadat Dehbidi,Gholamreza Rafiei Karimi,Mozhgan Asgari,Amir Esmaeili,Babak Zare,Farahnaz Farhadi,Ali Dabbaghmanesh,Mohammad Hossein Saki,Forough Behzad-Behbahani,Abbas |
dc.subject.por.fl_str_mv |
Human herpesvirus 6 Prevalence Hashimoto disease Autoimmune diseases |
topic |
Human herpesvirus 6 Prevalence Hashimoto disease Autoimmune diseases |
description |
ABSTRACT Background: Hypothyroidism due to Hashimoto's thyroiditis (HT) is the commonest autoimmune endocrine illness in which antibodies against thyroid organ result in inflammation. The disease has a complex etiology that involves genetic and environmental influences. Viral infections may be involved in triggering of the disease as their molecular mimicry enhance autoimmune responses. Human herpesvirus-6 (HHV-6) is recognized for its contribution to some autoimmune diseases. Objective: In the current study, the prevalence of HHV-6 active infection in patients with HT and with non-autoimmune thyroid disorders were compared with patients with euthyroidism. In addition, a correlation between presence of HHV-6 infections and HT was investigated. Methods: A total of 151 patients with clinically and laboratory confirmed HT, 59 patients with non-autoimmune thyroid disorders, and 32 patients with normal thyroid function were included in the study. For further confirmation of HT disease, all the precipitants were tested for anti-thyroid peroxidase (TPO), and anti-thyroglobulin (TG) antibodies. For detection of both HHV-6 types A and B, nested PCR and restriction enzyme digestion were used. HHV-6 DNA positive samples were further investigated by DNA sequencing analysis. Results: HHV-6A DNA was found in serum sample of 57 out of 151 patients (38%) with HT, which was significantly more often than in patients with non-autoimmune thyroid disorders (p = 0.001). However, HHV-6 DNA was not detected in serum samples of euthyroid subjects. Conclusions: The results support a possible role for active HHV-6A infection, demonstrated by the presence of HHV-6 DNA in sera, in the development of HT. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600435 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600435 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjid.2019.10.004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
Brazilian Journal of Infectious Diseases v.23 n.6 2019 reponame:Brazilian Journal of Infectious Diseases instname:Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
instname_str |
Brazilian Society of Infectious Diseases (BSID) |
instacron_str |
BSID |
institution |
BSID |
reponame_str |
Brazilian Journal of Infectious Diseases |
collection |
Brazilian Journal of Infectious Diseases |
repository.name.fl_str_mv |
Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID) |
repository.mail.fl_str_mv |
bjid@bjid.org.br||lgoldani@ufrgs.br |
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1754209244714893312 |