Association between changes in serum and skeletal muscle metabolomics profile with maximum power output gains in response to different aerobic training programs : the times study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório da Produção Científica e Intelectual da Unicamp |
| Texto Completo: | https://hdl.handle.net/20.500.12733/3676 |
Resumo: | Agradecimentos: We thank the Nuclear Magnetic Resonance (NMR) Facility at the Brazilian Biosciences National Laboratory (LNBio) for the use of the NMR spectrometer (600MHz, Varian Inova), and the Integrated Laboratory of Education and Research (LABFEF) at the University of Campinas for the Body Composition Tracking System (BOD POD, Cosmed, USA). We also thank Espaço da Escrita – Pró-Reitoria de Pesquisa – UNICAMP – for the language services provided |
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Association between changes in serum and skeletal muscle metabolomics profile with maximum power output gains in response to different aerobic training programs : the times studyTreino aeróbicoMetabolômicaMetabolomics profileAgradecimentos: We thank the Nuclear Magnetic Resonance (NMR) Facility at the Brazilian Biosciences National Laboratory (LNBio) for the use of the NMR spectrometer (600MHz, Varian Inova), and the Integrated Laboratory of Education and Research (LABFEF) at the University of Campinas for the Body Composition Tracking System (BOD POD, Cosmed, USA). We also thank Espaço da Escrita – Pró-Reitoria de Pesquisa – UNICAMP – for the language services providedAbstract: High heterogeneity of the response of cardiorespiratory fitness (CRF) to standardized exercise doses has been reported in different training programs, but the associated mechanisms are not widely known. This study investigated whether changes in the metabolic profile and pathways in blood serum and the skeletal muscle are associated with the inter-individual variability of CRF responses to 8-wk of continuous endurance training (ET) or high-intensity interval training (HIIT). Eighty men, young and sedentary, were randomized into three groups, of which 70 completed 8 wk of intervention (> 90% of sessions): ET, HIIT, or control. Blood and vastus lateralis muscle tissue samples, as well as the measurement of CRF [maximal power output (MPO)] were obtained before and after the intervention. Blood serum and skeletal muscle samples were analyzed by 600 MHz 1H-NMR spectroscopy (metabolomics). Associations between the pretraining to post-training changes in the metabolic profile and MPO gains were explored via three analytical approaches: (1) correlation between pretraining to post-training changes in metabolites’ concentration levels and MPO gains; (2) significant differences between low and high MPO responders; and (3) metabolite contribution to significantly altered pathways related to MPO gains. After, metabolites within these three levels of evidence were analyzed by multiple stepwise linear regression. The significance level was set at 1%. The metabolomics profile panel yielded 43 serum and 70 muscle metabolites. From the metabolites within the three levels of evidence (15 serum and 4 muscle metabolites for ET; 5 serum and 1 muscle metabolites for HIIT), the variance in MPO gains was explained: 77.4% by the intervention effects, 6.9, 2.3, 3.2, and 2.2% by changes in skeletal muscle pyruvate and valine, serum glutamine and creatine phosphate, respectively, in ET; and 80.9% by the intervention effects; 7.2, 2.2, and 1.2% by changes in skeletal muscle glycolate, serum creatine and creatine phosphate, respectively, in HIIT. The most changed and impacted pathways by these metabolites were: arginine and proline metabolism, glycine, serine and threonine metabolism, and glyoxylate and dicarboxylate metabolism for both ET and HIIT programs; and additional alanine, aspartate and glutamate metabolism, arginine biosynthesis, gycolysis/gluconeogenesis, and pyruvate metabolism for ET. Conclusion: These results suggest that regulating the metabolism of amino acids and carbohydrates may be a potential mechanism for understanding the inter-individual variability of CRF in responses to ET and HIIT programsFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESAbertoUNIVERSIDADE ESTADUAL DE CAMPINASCastro, Alex, 1990-Duft, Renata Garbellini, 1990Nunes, Silas Gabriel de Oliveira, 1996-Cavaglieri, Claudia Regina, 1963-Chacon-Mikahil, Mara Patrícia Traina, 1965-2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12733/3676CASTRO, Alex et al. Association between changes in serum and skeletal muscle metabolomics profile with maximum power output gains in response to different aerobic training programs: the times study. Frontiers in physiology. Lausanne : Frontiers Research Foundation, 2016. Vol. 12 (out., 2021), n. art. 756618. Disponível em: https://hdl.handle.net/20.500.12733/3676. Acesso em: 7 mai. 2024.Inglêsenghttps://repositorio.unicamp.br/acervo/detalhe/1239540reponame:Repositório da Produção Científica e Intelectual da Unicampinstname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPinfo:eu-repo/semantics/openAccess2022-08-19T14:30:06Zoai:https://www.repositorio.unicamp.br/:1239540Repositório InstitucionalPUBhttp://repositorio.unicamp.br/oai/requestreposip@unicamp.bropendoar:2022-08-19T14:30:06Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP)false |
| dc.title.none.fl_str_mv |
Association between changes in serum and skeletal muscle metabolomics profile with maximum power output gains in response to different aerobic training programs : the times study |
| title |
Association between changes in serum and skeletal muscle metabolomics profile with maximum power output gains in response to different aerobic training programs : the times study |
| spellingShingle |
Association between changes in serum and skeletal muscle metabolomics profile with maximum power output gains in response to different aerobic training programs : the times study Castro, Alex, 1990- Treino aeróbico Metabolômica Metabolomics profile |
| title_short |
Association between changes in serum and skeletal muscle metabolomics profile with maximum power output gains in response to different aerobic training programs : the times study |
| title_full |
Association between changes in serum and skeletal muscle metabolomics profile with maximum power output gains in response to different aerobic training programs : the times study |
| title_fullStr |
Association between changes in serum and skeletal muscle metabolomics profile with maximum power output gains in response to different aerobic training programs : the times study |
| title_full_unstemmed |
Association between changes in serum and skeletal muscle metabolomics profile with maximum power output gains in response to different aerobic training programs : the times study |
| title_sort |
Association between changes in serum and skeletal muscle metabolomics profile with maximum power output gains in response to different aerobic training programs : the times study |
| author |
Castro, Alex, 1990- |
| author_facet |
Castro, Alex, 1990- Duft, Renata Garbellini, 1990 Nunes, Silas Gabriel de Oliveira, 1996- Cavaglieri, Claudia Regina, 1963- Chacon-Mikahil, Mara Patrícia Traina, 1965- |
| author_role |
author |
| author2 |
Duft, Renata Garbellini, 1990 Nunes, Silas Gabriel de Oliveira, 1996- Cavaglieri, Claudia Regina, 1963- Chacon-Mikahil, Mara Patrícia Traina, 1965- |
| author2_role |
author author author author |
| dc.contributor.none.fl_str_mv |
UNIVERSIDADE ESTADUAL DE CAMPINAS |
| dc.contributor.author.fl_str_mv |
Castro, Alex, 1990- Duft, Renata Garbellini, 1990 Nunes, Silas Gabriel de Oliveira, 1996- Cavaglieri, Claudia Regina, 1963- Chacon-Mikahil, Mara Patrícia Traina, 1965- |
| dc.subject.por.fl_str_mv |
Treino aeróbico Metabolômica Metabolomics profile |
| topic |
Treino aeróbico Metabolômica Metabolomics profile |
| description |
Agradecimentos: We thank the Nuclear Magnetic Resonance (NMR) Facility at the Brazilian Biosciences National Laboratory (LNBio) for the use of the NMR spectrometer (600MHz, Varian Inova), and the Integrated Laboratory of Education and Research (LABFEF) at the University of Campinas for the Body Composition Tracking System (BOD POD, Cosmed, USA). We also thank Espaço da Escrita – Pró-Reitoria de Pesquisa – UNICAMP – for the language services provided |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/20.500.12733/3676 CASTRO, Alex et al. Association between changes in serum and skeletal muscle metabolomics profile with maximum power output gains in response to different aerobic training programs: the times study. Frontiers in physiology. Lausanne : Frontiers Research Foundation, 2016. Vol. 12 (out., 2021), n. art. 756618. Disponível em: https://hdl.handle.net/20.500.12733/3676. Acesso em: 7 mai. 2024. |
| url |
https://hdl.handle.net/20.500.12733/3676 |
| identifier_str_mv |
CASTRO, Alex et al. Association between changes in serum and skeletal muscle metabolomics profile with maximum power output gains in response to different aerobic training programs: the times study. Frontiers in physiology. Lausanne : Frontiers Research Foundation, 2016. Vol. 12 (out., 2021), n. art. 756618. Disponível em: https://hdl.handle.net/20.500.12733/3676. Acesso em: 7 mai. 2024. |
| dc.language.iso.fl_str_mv |
Inglês eng |
| language_invalid_str_mv |
Inglês |
| language |
eng |
| dc.relation.none.fl_str_mv |
https://repositorio.unicamp.br/acervo/detalhe/1239540 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório da Produção Científica e Intelectual da Unicamp instname:Universidade Estadual de Campinas (UNICAMP) instacron:UNICAMP |
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Universidade Estadual de Campinas (UNICAMP) |
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UNICAMP |
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UNICAMP |
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Repositório da Produção Científica e Intelectual da Unicamp |
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Repositório da Produção Científica e Intelectual da Unicamp |
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Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP) |
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reposip@unicamp.br |
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