Mechanisms Involved in the Regeneration of Peripheral Nerve Injuries

• Autor(a) principal: Silva, Carolina Kruleske da
• Data de Publicação: 2010
• Outros Autores: Camargo, Edson Amaral
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Saúde e Pesquisa (Online)
• Texto Completo: https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/1392
• topic: Peripheral Nerves; Injuries; Nerve Regeneration; Nervous System Physiological Phenomena.; Nervos periféricos; Lesão; Regeneração nervosa; Fenômenos Fisiológicos do Sistema Nervoso.

Peripheral nerve injuries are common and result in motor sensory and autonomic disability. Even in the best circumstances regeneration is rarely completely effective. The peripheral nerve regeneration involves the integration of various cellular and molecular processes followed by a series of changes observed in structures related to the injury site. In recent years the knowledge on mechanisms involved in this process has been deeply studied through clinical and experimental research. The expectation of inclusion of new treatment strategies, including neuro-engineering, molecular therapy, neuroprotective pharmacotherapy, modulation of neurotrophic factors, transplanting of embryonic cells and recent knowledge on brain plasticity secondary to these injuries may be added to current concepts of surgical and conservatory treatment for better functional results. Current study presents the main mechanisms involved in injury and regeneration of peripheral nerves and the perspectives of new treatment strategies.