EVALUATION OF THE QUALITY OF FORMULATIONS WITH HYDROQUINONE DISPENSED IN PHARMACIES IN MARINGÁ PR BRAZIL

Detalhes bibliográficos
Autor(a) principal: Rocha Manzotti, Lenon
Data de Publicação: 2013
Outros Autores: Felipe, Daniele Fernanda
Tipo de documento: Artigo
Idioma: por
Título da fonte: Saúde e Pesquisa (Online)
Texto Completo: https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/2631
Resumo: Dispensing pharmacies are an alternative for patients that need specific treatments and individualized doses. Hydroquinone is prescribed by dermatologists although it oxidizes fast. Current research deals with quality control in creams with hydroquinone dispensed in ten pharmacies in Maringá PR Brazil. A sample was provided from each pharmacy. All samples had anti-oxidants and half of the samples were conditioned in aluminum tubes. This was recommended; recommendation also deals with their maintenance in a fridge. Only one (10%) had the recommended dosage whereas in eight samples (80%) the dose was above the permitted rate and one (10%) was below. Results show that dispensing pharmacies have enough care to avoid oxidization but evaluation of doses is not without concern and may decrease the efficiency or cause toxicity in the patient.
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spelling EVALUATION OF THE QUALITY OF FORMULATIONS WITH HYDROQUINONE DISPENSED IN PHARMACIES IN MARINGÁ PR BRAZILAvaliação da Qualidade de Formulações Contendo Hidroquinona Manipuladas em Farmácias de Maringá - PRDispensing PharmaciesHydroquinoneQuality ControlOxidationFarmácia MagistralHidroquinonaControle de QualidadeOxidação.Dispensing pharmacies are an alternative for patients that need specific treatments and individualized doses. Hydroquinone is prescribed by dermatologists although it oxidizes fast. Current research deals with quality control in creams with hydroquinone dispensed in ten pharmacies in Maringá PR Brazil. A sample was provided from each pharmacy. All samples had anti-oxidants and half of the samples were conditioned in aluminum tubes. This was recommended; recommendation also deals with their maintenance in a fridge. Only one (10%) had the recommended dosage whereas in eight samples (80%) the dose was above the permitted rate and one (10%) was below. Results show that dispensing pharmacies have enough care to avoid oxidization but evaluation of doses is not without concern and may decrease the efficiency or cause toxicity in the patient.A farmácia magistral é uma alternativa para pacientes que buscam tratamentos específicos e doses individualizadas. A hidroquinona é um despigmentante muito prescrito por dermatologistas, porém, é uma substância que se oxida facilmente. Diante do exposto, o objetivo deste trabalho foi a realização do controle de qualidade em cremes contendo hidroquinona manipulados em dez farmácias de Maringá - PR, onde foram adquiridas uma amostra de cada estabelecimento. Essas amostras foram submetidas à análise sensorial, onde se avaliou cor, odor e aspecto, além do valor de pH e teor de hidroquinona (doseamento) por titulação de oxido-redução. De acordo com os resultados obtidos, verifica-se que todas as amostras fizeram uso de antioxidantes, sendo que a metade das amostras foi acondicionada em bisnagas de alumínio (recomendável), além de recomendar que as mesmas fossem mantidas sob refrigeração. Quanto ao doseamento, apenas 1 (10%) se manteve dentro da faixa recomendada, enquanto 8 (80%) das amostras encontraram valor acima do permitindo e 1 (10%) apresentou resultado abaixo da faixa recomendada. Pode-se concluir que as farmácias magistrais estão tendo o cuidado em prevenir a oxidação, porém, os resultados obtidos com o doseamento são preocupantes, podendo levar a diminuição da eficácia ou toxicidade ao paciente.Universidade Cesumar - UniCesumar2013-06-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado por Paresapplication/pdfhttps://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/2631Saúde e Pesquisa; Vol 6 No 3 (2013): set./dez.Saúde e Pesquisa; v. 6 n. 3 (2013): set./dez.2176-9206reponame:Saúde e Pesquisa (Online)instname:Cesumar Diretoria de Pesquisainstacron:CESUMARporhttps://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/2631/2149Rocha Manzotti, LenonFelipe, Daniele Fernandainfo:eu-repo/semantics/openAccess2020-09-04T12:26:23Zoai:ojs.pkp.sfu.ca:article/2631Revistahttps://periodicos.unicesumar.edu.br/index.php/saudpesqPUBhttps://periodicos.unicesumar.edu.br/index.php/saudpesq/oainaep@cesumar.br2176-92061983-1870opendoar:2020-09-04T12:26:23Saúde e Pesquisa (Online) - Cesumar Diretoria de Pesquisafalse
dc.title.none.fl_str_mv EVALUATION OF THE QUALITY OF FORMULATIONS WITH HYDROQUINONE DISPENSED IN PHARMACIES IN MARINGÁ PR BRAZIL
Avaliação da Qualidade de Formulações Contendo Hidroquinona Manipuladas em Farmácias de Maringá - PR
title EVALUATION OF THE QUALITY OF FORMULATIONS WITH HYDROQUINONE DISPENSED IN PHARMACIES IN MARINGÁ PR BRAZIL
spellingShingle EVALUATION OF THE QUALITY OF FORMULATIONS WITH HYDROQUINONE DISPENSED IN PHARMACIES IN MARINGÁ PR BRAZIL
Rocha Manzotti, Lenon
Dispensing Pharmacies
Hydroquinone
Quality Control
Oxidation
Farmácia Magistral
Hidroquinona
Controle de Qualidade
Oxidação
.
title_short EVALUATION OF THE QUALITY OF FORMULATIONS WITH HYDROQUINONE DISPENSED IN PHARMACIES IN MARINGÁ PR BRAZIL
title_full EVALUATION OF THE QUALITY OF FORMULATIONS WITH HYDROQUINONE DISPENSED IN PHARMACIES IN MARINGÁ PR BRAZIL
title_fullStr EVALUATION OF THE QUALITY OF FORMULATIONS WITH HYDROQUINONE DISPENSED IN PHARMACIES IN MARINGÁ PR BRAZIL
title_full_unstemmed EVALUATION OF THE QUALITY OF FORMULATIONS WITH HYDROQUINONE DISPENSED IN PHARMACIES IN MARINGÁ PR BRAZIL
title_sort EVALUATION OF THE QUALITY OF FORMULATIONS WITH HYDROQUINONE DISPENSED IN PHARMACIES IN MARINGÁ PR BRAZIL
author Rocha Manzotti, Lenon
author_facet Rocha Manzotti, Lenon
Felipe, Daniele Fernanda
author_role author
author2 Felipe, Daniele Fernanda
author2_role author
dc.contributor.author.fl_str_mv Rocha Manzotti, Lenon
Felipe, Daniele Fernanda
dc.subject.por.fl_str_mv Dispensing Pharmacies
Hydroquinone
Quality Control
Oxidation
Farmácia Magistral
Hidroquinona
Controle de Qualidade
Oxidação
.
topic Dispensing Pharmacies
Hydroquinone
Quality Control
Oxidation
Farmácia Magistral
Hidroquinona
Controle de Qualidade
Oxidação
.
description Dispensing pharmacies are an alternative for patients that need specific treatments and individualized doses. Hydroquinone is prescribed by dermatologists although it oxidizes fast. Current research deals with quality control in creams with hydroquinone dispensed in ten pharmacies in Maringá PR Brazil. A sample was provided from each pharmacy. All samples had anti-oxidants and half of the samples were conditioned in aluminum tubes. This was recommended; recommendation also deals with their maintenance in a fridge. Only one (10%) had the recommended dosage whereas in eight samples (80%) the dose was above the permitted rate and one (10%) was below. Results show that dispensing pharmacies have enough care to avoid oxidization but evaluation of doses is not without concern and may decrease the efficiency or cause toxicity in the patient.
publishDate 2013
dc.date.none.fl_str_mv 2013-06-17
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado por Pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/2631
url https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/2631
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/2631/2149
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Cesumar - UniCesumar
publisher.none.fl_str_mv Universidade Cesumar - UniCesumar
dc.source.none.fl_str_mv Saúde e Pesquisa; Vol 6 No 3 (2013): set./dez.
Saúde e Pesquisa; v. 6 n. 3 (2013): set./dez.
2176-9206
reponame:Saúde e Pesquisa (Online)
instname:Cesumar Diretoria de Pesquisa
instacron:CESUMAR
instname_str Cesumar Diretoria de Pesquisa
instacron_str CESUMAR
institution CESUMAR
reponame_str Saúde e Pesquisa (Online)
collection Saúde e Pesquisa (Online)
repository.name.fl_str_mv Saúde e Pesquisa (Online) - Cesumar Diretoria de Pesquisa
repository.mail.fl_str_mv naep@cesumar.br
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