Hepatitis B virus genotypes in Southeast Brazil and its relationship with histological features
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20157 |
Resumo: | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Histopatologia. Rio de Janeiro, RJ, Brasil. |
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Nabuco, Letícia CancellaMello, Francisco Campello do AmaralGomes, Selma de AndradePerez, Renata MelloCoelho, Henrique Sérgio MoraesNogueira, Cristiane Alves Villela2017-07-20T15:16:26Z2017-07-20T15:16:26Z2012NABUCO, Letícia Cancella; et al. Hepatitis B virus genotypes in Southeast Brazil and its relationship with histological features. Mem Inst Oswaldo Cruz, v.107, n.6, p.758-789, Sept. 2012.0074-0276https://www.arca.fiocruz.br/handle/icict/201571678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzHepatite BVírus da Hepatite BGenótipoHistologia do fígadoSudeste do BrasilHBV genotypeshepatitis BHBV-DNAliver histologyHBeAgALTSoutheast BrazilHepatitis B virus genotypes in Southeast Brazil and its relationship with histological featuresinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Histopatologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Histopatologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Histopatologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Histopatologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Histopatologia. Rio de Janeiro, RJ, Brasil.Data concerning the relationship between hepatitis B virus (HBV) genotypes and liver histology are scarce. The aim of this study was to compare HBV non-B and non-C genotypes according to demographic features, clinical status, HBV-DNA levels and liver histology in Rio de Janeiro. One hundred twenty one consecutive chronic HBVinfected patients were enrolled during two-year period and data were prospectively collected. Sera were tested for HBV genotyping using restriction fragment length polymorphism. Liver biopsy was obtained from patients with either increased alanine aminotransferase (ALT) or HBV-DNA levels. Genotype A was the most common, found in 82 (68%) patients, followed by F in 19 (15%), D in 17 (14%), B in one (1%) and C in two (2%). There was no association between HBV genotypes A, D and F and gender (p = 0.37), age (p = 0.78), race (p = 0.22), mode of infection (p = 0.94), HB “e” antigen status (p = 0.37) and HBV-DNA levels (p = 0.47). The ALT levels were lower in genotype D (75%) compared with A (47%) and F (55%) (p = 0.05). Liver biopsy showed lower inflammation [histological activity index (HAI) = 4] and fibrosis (F) (= 0) scores in genotype D than in genotypes A (HAI = 5, p < 0.001; F = 2, p = 0.008) or F (HAI = 5, p = 0.009; F = 2, p = 0.01). Genotype A was the most prevalent in chronic HBV-infected patients and genotype D patients presented with less intense liver disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20157/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALfrancisco3_mello_etal_IOC_2012.pdffrancisco3_mello_etal_IOC_2012.pdfapplication/pdf300635https://www.arca.fiocruz.br/bitstream/icict/20157/2/francisco3_mello_etal_IOC_2012.pdff697410fd8de5335b497b3c1adf78705MD52TEXTfrancisco3_mello_etal_IOC_2012.pdf.txtfrancisco3_mello_etal_IOC_2012.pdf.txtExtracted texttext/plain26930https://www.arca.fiocruz.br/bitstream/icict/20157/3/francisco3_mello_etal_IOC_2012.pdf.txt11ea798036f5a73b0ea34700d41cd112MD53icict/201572018-08-15 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dc.title.pt_BR.fl_str_mv |
Hepatitis B virus genotypes in Southeast Brazil and its relationship with histological features |
title |
Hepatitis B virus genotypes in Southeast Brazil and its relationship with histological features |
spellingShingle |
Hepatitis B virus genotypes in Southeast Brazil and its relationship with histological features Nabuco, Letícia Cancella Hepatite B Vírus da Hepatite B Genótipo Histologia do fígado Sudeste do Brasil HBV genotypes hepatitis B HBV-DNA liver histology HBeAg ALT Southeast Brazil |
title_short |
Hepatitis B virus genotypes in Southeast Brazil and its relationship with histological features |
title_full |
Hepatitis B virus genotypes in Southeast Brazil and its relationship with histological features |
title_fullStr |
Hepatitis B virus genotypes in Southeast Brazil and its relationship with histological features |
title_full_unstemmed |
Hepatitis B virus genotypes in Southeast Brazil and its relationship with histological features |
title_sort |
Hepatitis B virus genotypes in Southeast Brazil and its relationship with histological features |
author |
Nabuco, Letícia Cancella |
author_facet |
Nabuco, Letícia Cancella Mello, Francisco Campello do Amaral Gomes, Selma de Andrade Perez, Renata Mello Coelho, Henrique Sérgio Moraes Nogueira, Cristiane Alves Villela |
author_role |
author |
author2 |
Mello, Francisco Campello do Amaral Gomes, Selma de Andrade Perez, Renata Mello Coelho, Henrique Sérgio Moraes Nogueira, Cristiane Alves Villela |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Nabuco, Letícia Cancella Mello, Francisco Campello do Amaral Gomes, Selma de Andrade Perez, Renata Mello Coelho, Henrique Sérgio Moraes Nogueira, Cristiane Alves Villela |
dc.subject.other.pt_BR.fl_str_mv |
Hepatite B Vírus da Hepatite B Genótipo Histologia do fígado Sudeste do Brasil |
topic |
Hepatite B Vírus da Hepatite B Genótipo Histologia do fígado Sudeste do Brasil HBV genotypes hepatitis B HBV-DNA liver histology HBeAg ALT Southeast Brazil |
dc.subject.en.pt_BR.fl_str_mv |
HBV genotypes hepatitis B HBV-DNA liver histology HBeAg ALT Southeast Brazil |
description |
Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Histopatologia. Rio de Janeiro, RJ, Brasil. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2017-07-20T15:16:26Z |
dc.date.available.fl_str_mv |
2017-07-20T15:16:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
NABUCO, Letícia Cancella; et al. Hepatitis B virus genotypes in Southeast Brazil and its relationship with histological features. Mem Inst Oswaldo Cruz, v.107, n.6, p.758-789, Sept. 2012. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/20157 |
dc.identifier.issn.pt_BR.fl_str_mv |
0074-0276 |
dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
identifier_str_mv |
NABUCO, Letícia Cancella; et al. Hepatitis B virus genotypes in Southeast Brazil and its relationship with histological features. Mem Inst Oswaldo Cruz, v.107, n.6, p.758-789, Sept. 2012. 0074-0276 1678-8060 |
url |
https://www.arca.fiocruz.br/handle/icict/20157 |
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eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
publisher.none.fl_str_mv |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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