Multi-omic analyses of plasma cytokines, lipidomics, and transcriptomics distinguish treatment outcomes in Cutaneous Leishmaniasis
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/44781 |
Resumo: | Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil. |
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Santos, Hayna MaltaFukutani, Kyoshi F.Sorgi, Carlos A.Queiroz, Artur T. L.Nardini, VivianeSilva, JulianaLago, AlexCarvalho, Lucas P.Machado, Paulo L. R.Bozza, Patrícia T.Costa, Jaqueline FrançaFaccioli, Lúcia HelenaCarvalho, Edgar M.Andrade, Bruno de BezerrilBorges, Viviane M.2020-12-10T14:35:39Z2020-12-10T14:35:39Z2020SANTOS, Hayna Malta et al. Multi-omic Analyses of Plasma Cytokines, Lipidomics, and Transcriptomics Distinguish Treatment Outcomes in Cutaneous Leishmaniasis. iScience, v. 23, n. 12, 101840, 30p, Dec. 2020.https://www.arca.fiocruz.br/handle/icict/4478110.1016/j.isci.2020.1018402589-0042engScienceAnálises multiômicasCitocinas plasmáticasLipidômicaTranscriptômicaResultados no tratamentoCutaneous LeishmaniasisMulti-omic analysisPlasma CytokinesTranscriptomicsTreatmentMulti-omic analyses of plasma cytokines, lipidomics, and transcriptomics distinguish treatment outcomes in Cutaneous Leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Saçvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brazil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brazil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade Federal da Bahia. Serviço de Imunologia, C-HUPES. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Serviço de Imunologia, C-HUPES. Salvador, BA, Brasil.Universidade Federal da Bahia. Serviço de Imunologia, C-HUPES. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Serviço de Imunologia, C-HUPES. Salvador, BA, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil.Leishmania braziliensis infection frequently results in cutaneous leishmaniasis (CL). An increase in incidence of drug-resistant CL leading to treatment failure has been reported. Identification of reliable predictors of treatment outcomes is necessary to optimize patient care. Here, we performed a prospective case-control study in which plasma levels of cytokines and lipid mediators were assessed at different time points during antileishmanial therapy in patients with CL from Brazil. Multidimensional analyses were employed to describe a combination of biomarkers able to predict and characterize treatment failure. We found a biosignature influenced mainly by plasma levels of lipid mediators that accurately predicted treatment failure. Furthermore, transcriptomic analysis of a publicly available data set revealed that expression levels of genes related to lipid metabolism measured in skin lesions could distinguish treatment outcomes in CL. Thus, activation of pathways linked to lipid biosynthesis predicts treatment failure in CL. The biomarkers identified may be further explored as therapeutic targets.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44781/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPatriciaT_Bozza_etal_IOC_2020.pdfPatriciaT_Bozza_etal_IOC_2020.pdfapplication/pdf5391594https://www.arca.fiocruz.br/bitstream/icict/44781/2/PatriciaT_Bozza_etal_IOC_2020.pdf07058fb18c192597f8cddfdf5598bca3MD52TEXTPatriciaT_Bozza_etal_IOC_2020.pdf.txtPatriciaT_Bozza_etal_IOC_2020.pdf.txtExtracted texttext/plain74415https://www.arca.fiocruz.br/bitstream/icict/44781/3/PatriciaT_Bozza_etal_IOC_2020.pdf.txtaf74032d55b0780444bf63a8bd591823MD53icict/447812023-09-14 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dc.title.pt_BR.fl_str_mv |
Multi-omic analyses of plasma cytokines, lipidomics, and transcriptomics distinguish treatment outcomes in Cutaneous Leishmaniasis |
title |
Multi-omic analyses of plasma cytokines, lipidomics, and transcriptomics distinguish treatment outcomes in Cutaneous Leishmaniasis |
spellingShingle |
Multi-omic analyses of plasma cytokines, lipidomics, and transcriptomics distinguish treatment outcomes in Cutaneous Leishmaniasis Santos, Hayna Malta Análises multiômicas Citocinas plasmáticas Lipidômica Transcriptômica Resultados no tratamento Cutaneous Leishmaniasis Multi-omic analysis Plasma Cytokines Transcriptomics Treatment |
title_short |
Multi-omic analyses of plasma cytokines, lipidomics, and transcriptomics distinguish treatment outcomes in Cutaneous Leishmaniasis |
title_full |
Multi-omic analyses of plasma cytokines, lipidomics, and transcriptomics distinguish treatment outcomes in Cutaneous Leishmaniasis |
title_fullStr |
Multi-omic analyses of plasma cytokines, lipidomics, and transcriptomics distinguish treatment outcomes in Cutaneous Leishmaniasis |
title_full_unstemmed |
Multi-omic analyses of plasma cytokines, lipidomics, and transcriptomics distinguish treatment outcomes in Cutaneous Leishmaniasis |
title_sort |
Multi-omic analyses of plasma cytokines, lipidomics, and transcriptomics distinguish treatment outcomes in Cutaneous Leishmaniasis |
dc.creator.affilliation.pt_BR.fl_str_mv |
|
author |
Santos, Hayna Malta |
author_facet |
Santos, Hayna Malta Fukutani, Kyoshi F. Sorgi, Carlos A. Queiroz, Artur T. L. Nardini, Viviane Silva, Juliana Lago, Alex Carvalho, Lucas P. Machado, Paulo L. R. Bozza, Patrícia T. Costa, Jaqueline França Faccioli, Lúcia Helena Carvalho, Edgar M. Andrade, Bruno de Bezerril Borges, Viviane M. |
author_role |
author |
author2 |
Fukutani, Kyoshi F. Sorgi, Carlos A. Queiroz, Artur T. L. Nardini, Viviane Silva, Juliana Lago, Alex Carvalho, Lucas P. Machado, Paulo L. R. Bozza, Patrícia T. Costa, Jaqueline França Faccioli, Lúcia Helena Carvalho, Edgar M. Andrade, Bruno de Bezerril Borges, Viviane M. |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Santos, Hayna Malta Fukutani, Kyoshi F. Sorgi, Carlos A. Queiroz, Artur T. L. Nardini, Viviane Silva, Juliana Lago, Alex Carvalho, Lucas P. Machado, Paulo L. R. Bozza, Patrícia T. Costa, Jaqueline França Faccioli, Lúcia Helena Carvalho, Edgar M. Andrade, Bruno de Bezerril Borges, Viviane M. |
dc.subject.other.pt_BR.fl_str_mv |
Análises multiômicas Citocinas plasmáticas Lipidômica Transcriptômica Resultados no tratamento |
topic |
Análises multiômicas Citocinas plasmáticas Lipidômica Transcriptômica Resultados no tratamento Cutaneous Leishmaniasis Multi-omic analysis Plasma Cytokines Transcriptomics Treatment |
dc.subject.en.pt_BR.fl_str_mv |
Cutaneous Leishmaniasis Multi-omic analysis Plasma Cytokines Transcriptomics Treatment |
description |
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-12-10T14:35:39Z |
dc.date.available.fl_str_mv |
2020-12-10T14:35:39Z |
dc.date.issued.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SANTOS, Hayna Malta et al. Multi-omic Analyses of Plasma Cytokines, Lipidomics, and Transcriptomics Distinguish Treatment Outcomes in Cutaneous Leishmaniasis. iScience, v. 23, n. 12, 101840, 30p, Dec. 2020. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/44781 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.isci.2020.101840 |
dc.identifier.eissn.none.fl_str_mv |
2589-0042 |
identifier_str_mv |
SANTOS, Hayna Malta et al. Multi-omic Analyses of Plasma Cytokines, Lipidomics, and Transcriptomics Distinguish Treatment Outcomes in Cutaneous Leishmaniasis. iScience, v. 23, n. 12, 101840, 30p, Dec. 2020. 10.1016/j.isci.2020.101840 2589-0042 |
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https://www.arca.fiocruz.br/handle/icict/44781 |
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eng |
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eng |
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Science |
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Science |
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