Evolution and assembly of Anopheles aquasalis's immune genes: primary malaria vector of coastal Central and South America and the Caribbean Islands

Detalhes bibliográficos
Autor(a) principal: Sepulveda, Cesar Camilo Prado
Data de Publicação: 2023
Outros Autores: Alencar, Rodrigo Maciel, Santana, Rosa Amélia, Souza, Igor Belém de, D'Elia, Gigliola Mayra Ayres, Godoy, Raquel Soares Maia, Duarte, Ana Paula, Lopes, Stefanie Costa Pinto, Lacerda, Marcus Vinicius Guimarães de, Monteiro, Wuelton Marcelo, Pimenta, Rafael Nacif, Secundino, Nágila Francinete Costa, Koerich, Leonardo Barbosa, Pimenta, Paulo Filemon Paolucci
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/60138
Resumo: Fundação de Medicina Tropical Heitor Vieira Dourado. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Fundação de Medicina Tropical Heitor Vieira Dourado. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brazil.
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spelling Sepulveda, Cesar Camilo PradoAlencar, Rodrigo MacielSantana, Rosa AméliaSouza, Igor Belém deD'Elia, Gigliola Mayra AyresGodoy, Raquel Soares MaiaDuarte, Ana PaulaLopes, Stefanie Costa PintoLacerda, Marcus Vinicius Guimarães deMonteiro, Wuelton MarceloPimenta, Rafael NacifSecundino, Nágila Francinete CostaKoerich, Leonardo BarbosaPimenta, Paulo Filemon Paolucci2023-08-17T13:11:30Z2023-08-17T13:11:30Z2023PRADO SEPULVEDA, Cesar Camilo et al. Evolution and assembly of Anopheles aquasalis's immune genes: primary malaria vector of coastal Central and South America and the Caribbean Islands. Open Biology, v. 13, n. 7, 230061, 2023. doi: 10.1098/rsob.230061.2046-2441https://www.arca.fiocruz.br/handle/icict/60138engRoyal Society Pub.Evolution and assembly of Anopheles aquasalis's immune genes: primary malaria vector of coastal Central and South America and the Caribbean Islandsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação de Medicina Tropical Heitor Vieira Dourado. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Fundação de Medicina Tropical Heitor Vieira Dourado. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brazil.Fundação de Medicina Tropical Heitor Vieira Dourado. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Fundação de Medicina Tropical Heitor Vieira Dourado. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brazil.Fundação de Medicina Tropical Heitor Vieira Dourado. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Fundação de Medicina Tropical Heitor Vieira Dourado. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brazil.Fundação de Medicina Tropical Heitor Vieira Dourado. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Fundação de Medicina Tropical Heitor Vieira Dourado. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brazil.Fundação de Medicina Tropical Heitor Vieira Dourado. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Fundação de Medicina Tropical Heitor Vieira Dourado. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Instituto de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto de Pesquisas René Rachou. Programa de Pós-Graduação em Ciências da Saúde. Belo Horizonte. MG, Brazil.Fundação de Medicina Tropical Heitor Vieira Dourado. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Fundação de Medicina Tropical Heitor Vieira Dourado. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brazil.Fundação de Medicina Tropical Heitor Vieira Dourado. Manaus, AM, Brazil/Fundação Oswaldo Cruz. Instituto de Pesquisas Leônidas e Maria Deane. Manaus, AM, Brazil.Fundação de Medicina Tropical Heitor Vieira Dourado. Manaus, AM, Brazil/Fundação Oswaldo Cruz. Instituto de Pesquisas Leônidas e Maria Deane. Manaus, AM, Brazil.Fundação de Medicina Tropical Heitor Vieira Dourado. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Fundação de Medicina Tropical Heitor Vieira Dourado. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brazil/ University of Texas Medical Branch. Galveston, TX, USA.Departament of Epidemiology of Microbial Disease. Yale School of Public Health. New Haven, CT, USA.Fundação de Medicina Tropical Heitor Vieira Dourado. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Fundação de Medicina Tropical Heitor Vieira Dourado. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brazil/Fundação Oswaldo Cruz. Instituto de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto de Pesquisas René Rachou. Programa de Pós-Graduação em Ciências da Saúde. Belo Horizonte. MG, Brazil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil.Fundação de Medicina Tropical Heitor Vieira Dourado. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Fundação de Medicina Tropical Heitor Vieira Dourado. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brazil/Fundação Oswaldo Cruz. Instituto de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto de Pesquisas René Rachou. Programa de Pós-Graduação em Ciências da Saúde. Belo Horizonte. MG, Brazil.Anophelines are vectors of malaria, the deadliest disease worldwide transmitted by mosquitoes. The availability of genomic data from various Anopheles species allowed evolutionary comparisons of the immune response genes in search of alternative vector control of the malarial parasites. Now, with the Anopheles aquasalis genome, it was possible to obtain more information about the evolution of the immune response genes. Anopheles aquasalis has 278 immune genes in 24 families or groups. Comparatively, the American anophelines possess fewer genes than Anopheles gambiae s. s., the most dangerous African vector. The most remarkable differences were found in the pathogen recognition and modulation families like FREPs, CLIP and C-type lectins. Even so, genes related to the modulation of the expression of effectors in response to pathogens and gene families that control the production of reactive oxygen species were more conserved. Overall, the results show a variable pattern of evolution in the immune response genes in the anopheline species. Environmental factors, such as exposure to different pathogens and differences in the microbiota composition, could shape the expression of this group of genes. The results presented here will contribute to a better knowledge of the Neotropical vector and open opportunities for malaria control in the endemic-affected areas of the New World.anophelinesdiverged evolutiongenomeimmune responsemicrobiotainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/60138/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALevolution and assembly of anopheles.pdfevolution and assembly of anopheles.pdfapplication/pdf3425999https://www.arca.fiocruz.br/bitstream/icict/60138/2/evolution%20and%20assembly%20of%20anopheles.pdfc29123b00501c85cebbe8f568cb4f341MD52icict/601382023-08-17 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dc.title.en_US.fl_str_mv Evolution and assembly of Anopheles aquasalis's immune genes: primary malaria vector of coastal Central and South America and the Caribbean Islands
title Evolution and assembly of Anopheles aquasalis's immune genes: primary malaria vector of coastal Central and South America and the Caribbean Islands
spellingShingle Evolution and assembly of Anopheles aquasalis's immune genes: primary malaria vector of coastal Central and South America and the Caribbean Islands
Sepulveda, Cesar Camilo Prado
anophelines
diverged evolution
genome
immune response
microbiota
title_short Evolution and assembly of Anopheles aquasalis's immune genes: primary malaria vector of coastal Central and South America and the Caribbean Islands
title_full Evolution and assembly of Anopheles aquasalis's immune genes: primary malaria vector of coastal Central and South America and the Caribbean Islands
title_fullStr Evolution and assembly of Anopheles aquasalis's immune genes: primary malaria vector of coastal Central and South America and the Caribbean Islands
title_full_unstemmed Evolution and assembly of Anopheles aquasalis's immune genes: primary malaria vector of coastal Central and South America and the Caribbean Islands
title_sort Evolution and assembly of Anopheles aquasalis's immune genes: primary malaria vector of coastal Central and South America and the Caribbean Islands
author Sepulveda, Cesar Camilo Prado
author_facet Sepulveda, Cesar Camilo Prado
Alencar, Rodrigo Maciel
Santana, Rosa Amélia
Souza, Igor Belém de
D'Elia, Gigliola Mayra Ayres
Godoy, Raquel Soares Maia
Duarte, Ana Paula
Lopes, Stefanie Costa Pinto
Lacerda, Marcus Vinicius Guimarães de
Monteiro, Wuelton Marcelo
Pimenta, Rafael Nacif
Secundino, Nágila Francinete Costa
Koerich, Leonardo Barbosa
Pimenta, Paulo Filemon Paolucci
author_role author
author2 Alencar, Rodrigo Maciel
Santana, Rosa Amélia
Souza, Igor Belém de
D'Elia, Gigliola Mayra Ayres
Godoy, Raquel Soares Maia
Duarte, Ana Paula
Lopes, Stefanie Costa Pinto
Lacerda, Marcus Vinicius Guimarães de
Monteiro, Wuelton Marcelo
Pimenta, Rafael Nacif
Secundino, Nágila Francinete Costa
Koerich, Leonardo Barbosa
Pimenta, Paulo Filemon Paolucci
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sepulveda, Cesar Camilo Prado
Alencar, Rodrigo Maciel
Santana, Rosa Amélia
Souza, Igor Belém de
D'Elia, Gigliola Mayra Ayres
Godoy, Raquel Soares Maia
Duarte, Ana Paula
Lopes, Stefanie Costa Pinto
Lacerda, Marcus Vinicius Guimarães de
Monteiro, Wuelton Marcelo
Pimenta, Rafael Nacif
Secundino, Nágila Francinete Costa
Koerich, Leonardo Barbosa
Pimenta, Paulo Filemon Paolucci
dc.subject.en.en_US.fl_str_mv anophelines
diverged evolution
genome
immune response
microbiota
topic anophelines
diverged evolution
genome
immune response
microbiota
description Fundação de Medicina Tropical Heitor Vieira Dourado. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Fundação de Medicina Tropical Heitor Vieira Dourado. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brazil.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-08-17T13:11:30Z
dc.date.available.fl_str_mv 2023-08-17T13:11:30Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PRADO SEPULVEDA, Cesar Camilo et al. Evolution and assembly of Anopheles aquasalis's immune genes: primary malaria vector of coastal Central and South America and the Caribbean Islands. Open Biology, v. 13, n. 7, 230061, 2023. doi: 10.1098/rsob.230061.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/60138
dc.identifier.issn.en_US.fl_str_mv 2046-2441
identifier_str_mv PRADO SEPULVEDA, Cesar Camilo et al. Evolution and assembly of Anopheles aquasalis's immune genes: primary malaria vector of coastal Central and South America and the Caribbean Islands. Open Biology, v. 13, n. 7, 230061, 2023. doi: 10.1098/rsob.230061.
2046-2441
url https://www.arca.fiocruz.br/handle/icict/60138
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Royal Society Pub.
publisher.none.fl_str_mv Royal Society Pub.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/60138/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/60138/2/evolution%20and%20assembly%20of%20anopheles.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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