Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs

Detalhes bibliográficos
Autor(a) principal: Santos, Luciane Amorim
Data de Publicação: 2015
Outros Autores: Gray, Rebecca R, Cunha, Joana Paixão Monteiro, Strazza, Evandra, Kashima, Simone G, Santos, Edson de Souza, Araújo, Thessika Hialla Almeida, Gonçalves, Marilda de Souza, Salemi, Marco, Alcantara, Luiz Carlos Júnior
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13754
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, Brasil
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spelling Santos, Luciane AmorimGray, Rebecca RCunha, Joana Paixão MonteiroStrazza, EvandraKashima, Simone GSantos, Edson de SouzaAraújo, Thessika Hialla AlmeidaGonçalves, Marilda de SouzaSalemi, MarcoAlcantara, Luiz Carlos Júnior2016-04-13T19:15:48Z2016-04-13T19:15:48Z2015SANTOS, L. A. et al. Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs. AIDS Research Human Retroviruses, v. 31, n. 9, p. 913-920, 2015.0889-2229https://www.arca.fiocruz.br/handle/icict/13754engMary Ann LiebertHIVHIV-1TransmissãoAmamentaçãoFemininoCriançaShort communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, BrasilUniversity of Florida College of Medicine. Department of Pathology, Immunology, and Laboratory Medicine. Gainesville, FloridaFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilUniversidade de São Paulo. Hemocentro de Ribeirão Preto. São Paulo, SP, BrasilUniversidade de São Paulo. Hemocentro de Ribeirão Preto. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, BrasilUniversity of Florida College of Medicine. Department of Pathology, Immunology, and Laboratory Medicine. Gainesville, FloridaFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, BrasilCharacterizing the impact of HIV transmission routes on viral genetic diversity can improve the understanding of the mechanisms of virus evolution and adaptation. HIV vertical transmission can occur in utero, during delivery, or while breastfeeding. The present study investigated the phylodynamics of the HIV-1 env gene in mother-tochild transmission by analyzing one chronically infected pair from Brazil and three acutely infected pairs from Zambia, with three to five time points. Sequences from 25 clones from each sample were obtained and aligned using Clustal X. ML trees were constructed in PhyML using the best evolutionary model. Bayesian analyses testing the relaxed and strict molecular clock were performed using BEAST and a Bayesian Skyline Plot (BSP) was construed. The genetic variability of previously described epitopes was investigated and compared between each individual time point and between mother and child sequences. The relaxed molecular clock was the bestfitted model for all datasets. The tree topologies did not show differentiation in the evolutionary dynamics of the virus circulating in the mother from the viral population in the child. In the BSP, the effective population size was more constant in time in the chronically infected patients while in the acute patients it was possible to detect bottlenecks. The genetic variability within viral epitopes recognized by the human immune system was considerably higher among the chronically infected pair in comparison with acutely infected pairs. These results contribute to a better understanding of HIV-1 evolutionary dynamics in mother-to-child transmission.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13754/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSantos LA Short Communications Phylodynamics....pdfSantos LA Short Communications Phylodynamics....pdfapplication/pdf471633https://www.arca.fiocruz.br/bitstream/icict/13754/2/Santos%20LA%20Short%20Communications%20Phylodynamics....pdf44c725c25571d9a8241ad5e812f6978cMD52TEXTSantos LA Short Communications Phylodynamics....pdf.txtSantos LA Short Communications Phylodynamics....pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs
title Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs
spellingShingle Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs
Santos, Luciane Amorim
HIV
HIV-1
Transmissão
Amamentação
Feminino
Criança
title_short Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs
title_full Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs
title_fullStr Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs
title_full_unstemmed Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs
title_sort Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs
author Santos, Luciane Amorim
author_facet Santos, Luciane Amorim
Gray, Rebecca R
Cunha, Joana Paixão Monteiro
Strazza, Evandra
Kashima, Simone G
Santos, Edson de Souza
Araújo, Thessika Hialla Almeida
Gonçalves, Marilda de Souza
Salemi, Marco
Alcantara, Luiz Carlos Júnior
author_role author
author2 Gray, Rebecca R
Cunha, Joana Paixão Monteiro
Strazza, Evandra
Kashima, Simone G
Santos, Edson de Souza
Araújo, Thessika Hialla Almeida
Gonçalves, Marilda de Souza
Salemi, Marco
Alcantara, Luiz Carlos Júnior
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santos, Luciane Amorim
Gray, Rebecca R
Cunha, Joana Paixão Monteiro
Strazza, Evandra
Kashima, Simone G
Santos, Edson de Souza
Araújo, Thessika Hialla Almeida
Gonçalves, Marilda de Souza
Salemi, Marco
Alcantara, Luiz Carlos Júnior
dc.subject.other.pt_BR.fl_str_mv HIV
HIV-1
Transmissão
Amamentação
Feminino
Criança
topic HIV
HIV-1
Transmissão
Amamentação
Feminino
Criança
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, Brasil
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-04-13T19:15:48Z
dc.date.available.fl_str_mv 2016-04-13T19:15:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, L. A. et al. Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs. AIDS Research Human Retroviruses, v. 31, n. 9, p. 913-920, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13754
dc.identifier.issn.none.fl_str_mv 0889-2229
identifier_str_mv SANTOS, L. A. et al. Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs. AIDS Research Human Retroviruses, v. 31, n. 9, p. 913-920, 2015.
0889-2229
url https://www.arca.fiocruz.br/handle/icict/13754
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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