Neuroinflammation and Brain Development: Possible Risk Factors in COVID-19-Infected Children

Detalhes bibliográficos
Autor(a) principal: Chagas, Luana da Silva
Data de Publicação: 2021
Outros Autores: Sandre, Poliana Capucho, Velasco, Patricia Coelho de, Marcondes, Henrique, Ribeiro, Natalia Cristina Aparecida Ribeiro e, Barreto, Aline Loureiro, Mauro, Luiza Beatriz Alves, Ferreira, Julia Huber, Serfaty, Claudio A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50899
Resumo: Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil.
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spelling Chagas, Luana da SilvaSandre, Poliana CapuchoVelasco, Patricia Coelho deMarcondes, HenriqueRibeiro, Natalia Cristina Aparecida Ribeiro eBarreto, Aline LoureiroMauro, Luiza Beatriz AlvesFerreira, Julia HuberSerfaty, Claudio A.2022-01-26T13:42:21Z2022-01-26T13:42:21Z2021CHAGAS, Luana da Silva et al. Neuroinflammation and Brain Development: Possible Risk Factors in COVID-19-Infected Children. Neuroimmunomodulation, p. 1 - 7, Feb. 2021.1021-7401https://www.arca.fiocruz.br/handle/icict/5089910.1159/0005128151423-0216engKargerCOVID-19NeuroinflamaçaoFatores de riscoDesenvolvimento do cérebroCrianças infectadasCOVID-19NeuroinflammationBrain DevelopmentRisk FactorsInfected ChildrenNeuroinflammation and Brain Development: Possible Risk Factors in COVID-19-Infected Childreninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Instituto de Nutrição. Departamento de Nutrição Aplicada. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de CIência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil.COVID-19, a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) betacoronavirus, affects children in a different way than it does in adults, with milder symptoms. However, several cases of neurological symptoms with neuroinflammatory syndromes, such as the multisystem inflammatory syndrome (MIS-C), following mild cases, have been reported. As with other viral infections, such as rubella, influenza, and cytomegalovirus, SARS-CoV-2 induces a surge of proinflammatory cytokines that affect microglial function, which can be harmful to brain development. Along with the viral induction of neuroinflammation, other noninfectious conditions may interact to produce additional inflammation, such as the nutritional imbalance of fatty acids and polyunsaturated fatty acids and alcohol consumption during pregnancy. Additionally, transient thyrotoxicosis induced by SARS-CoV-2 with secondary autoimmune hypothyroidism has been reported, which could go undetected during pregnancy. Together, those factors may pose additional risk factors for SARS-CoV-2 infection impacting mechanisms of neural development such as synaptic pruning and neural circuitry formation. The present review discusses those conditions in the perspective of the understanding of risk factors that should be considered and the possible emergence of neurodevelopmental disorders in COVID-19-infected children.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/50899/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPolyanaSandre_ClaudioSerfaty_etal_IOC_2021.pdfPolyanaSandre_ClaudioSerfaty_etal_IOC_2021.pdfapplication/pdf418381https://www.arca.fiocruz.br/bitstream/icict/50899/2/PolyanaSandre_ClaudioSerfaty_etal_IOC_2021.pdfe8888eaf5efbf4600774d1a87179da4dMD52icict/508992022-01-26 10:42:21.748oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-01-26T13:42:21Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.pt_BR.fl_str_mv Neuroinflammation and Brain Development: Possible Risk Factors in COVID-19-Infected Children
title Neuroinflammation and Brain Development: Possible Risk Factors in COVID-19-Infected Children
spellingShingle Neuroinflammation and Brain Development: Possible Risk Factors in COVID-19-Infected Children
Chagas, Luana da Silva
COVID-19
Neuroinflamaçao
Fatores de risco
Desenvolvimento do cérebro
Crianças infectadas
COVID-19
Neuroinflammation
Brain Development
Risk Factors
Infected Children
title_short Neuroinflammation and Brain Development: Possible Risk Factors in COVID-19-Infected Children
title_full Neuroinflammation and Brain Development: Possible Risk Factors in COVID-19-Infected Children
title_fullStr Neuroinflammation and Brain Development: Possible Risk Factors in COVID-19-Infected Children
title_full_unstemmed Neuroinflammation and Brain Development: Possible Risk Factors in COVID-19-Infected Children
title_sort Neuroinflammation and Brain Development: Possible Risk Factors in COVID-19-Infected Children
author Chagas, Luana da Silva
author_facet Chagas, Luana da Silva
Sandre, Poliana Capucho
Velasco, Patricia Coelho de
Marcondes, Henrique
Ribeiro, Natalia Cristina Aparecida Ribeiro e
Barreto, Aline Loureiro
Mauro, Luiza Beatriz Alves
Ferreira, Julia Huber
Serfaty, Claudio A.
author_role author
author2 Sandre, Poliana Capucho
Velasco, Patricia Coelho de
Marcondes, Henrique
Ribeiro, Natalia Cristina Aparecida Ribeiro e
Barreto, Aline Loureiro
Mauro, Luiza Beatriz Alves
Ferreira, Julia Huber
Serfaty, Claudio A.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Chagas, Luana da Silva
Sandre, Poliana Capucho
Velasco, Patricia Coelho de
Marcondes, Henrique
Ribeiro, Natalia Cristina Aparecida Ribeiro e
Barreto, Aline Loureiro
Mauro, Luiza Beatriz Alves
Ferreira, Julia Huber
Serfaty, Claudio A.
dc.subject.other.pt_BR.fl_str_mv COVID-19
Neuroinflamaçao
Fatores de risco
Desenvolvimento do cérebro
Crianças infectadas
topic COVID-19
Neuroinflamaçao
Fatores de risco
Desenvolvimento do cérebro
Crianças infectadas
COVID-19
Neuroinflammation
Brain Development
Risk Factors
Infected Children
dc.subject.en.pt_BR.fl_str_mv COVID-19
Neuroinflammation
Brain Development
Risk Factors
Infected Children
description Universidade Federal Fluminense. Instituto de Biologia. Departamento de Neurobiologia. Laboratório de Plasticidade Neural. Niterói, RJ, Brasil.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-01-26T13:42:21Z
dc.date.available.fl_str_mv 2022-01-26T13:42:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CHAGAS, Luana da Silva et al. Neuroinflammation and Brain Development: Possible Risk Factors in COVID-19-Infected Children. Neuroimmunomodulation, p. 1 - 7, Feb. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50899
dc.identifier.issn.pt_BR.fl_str_mv 1021-7401
dc.identifier.doi.none.fl_str_mv 10.1159/000512815
dc.identifier.eissn.none.fl_str_mv 1423-0216
identifier_str_mv CHAGAS, Luana da Silva et al. Neuroinflammation and Brain Development: Possible Risk Factors in COVID-19-Infected Children. Neuroimmunomodulation, p. 1 - 7, Feb. 2021.
1021-7401
10.1159/000512815
1423-0216
url https://www.arca.fiocruz.br/handle/icict/50899
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50899/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50899/2/PolyanaSandre_ClaudioSerfaty_etal_IOC_2021.pdf
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