Oral mucoceles: a clinical, histopathological and immunohistochemical study.
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8935 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Conceição, Jamile GomesGurgel, Clarissa Araújo SilvaRamos, Eduardo Antônio GonçalvesXavier, Flávia Caló De AquinoSalesa, Caroline Brandi SchlaepferCangussú, Maria Cristina TeixeiraCury, Patrícia RamosRamalho, Luciana Maria PedreiraSantos, Jean Nunes dos2014-11-21T14:05:53Z2014-11-21T14:05:53Z2013CONCEIÇÃO, J. G. et al. Oral mucoceles: a clinical, histopathological and immunohistochemical study. Acta Histochemica, v. 116, n. 1, p. 40-47, 2014.1618-0372https://www.arca.fiocruz.br/handle/icict/8935dx.doi.org/10.1016/j.acthis.2013.04.015engElsevierOral mucoceles: a clinical, histopathological and immunohistochemical study.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Department of Dental Public Health. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Department of Periodontics. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Department of Stomatology. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, BrasiltThe aim of study was to evaluate the clinicopathological features of oral mucoceles and the immunohisto-chemical expression of cellular and extracellular matrix components in these lesions. One hundred casesof oral mucoceles were examined for clinicopathological features. The expression of mast cell tryptase,CD68, MMP-1 (matrix metalloproteinase-1), MMP-9 (matrix metalloproteinase-9) and CD34 was inves-tigated immunohistochemically in 32 cases. The lesions arose as nodules or blisters of variable color. Themean age was 23.2 years and a higher male frequency was observed. The most common locations werethe lower lip (92%), followed by the floor of the mouth (7%), and palate (1%). The lesion size ranged from0.4 to 3.0 cm. Unusual histopathological findings as superficial mucoceles (n = 16, 16%), pseudopapillaryprojections (n = 3, 3%), epithelioid histiocytes (n = 4, 4%), multinucleated giant cells (n = 1, 1%) and myx-oglobulosis (n = 9, 9%) were also seen. Mast cells and CD68-positive macrophages, MMP-1, MMP-9 andCD34-positive blood vessels were seen in all cases. A significant association was seen between mast cellsand MMP-1 (p = 0.03) and between macrophages and MMP-1 (p = 0.01). This study provided importantinsight into the demographic and histopathological occurrence of oral mucoceles. The tissue remodel-ing seen in these lesions mainly involved the migration and interaction of mast cells, macrophages andMMP-1.Oral mucocelesHistopathologyMyxoglobulosisImmunohistochemistryinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8935/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALConceicao JG Oral mucoceles...pdfConceicao JG Oral mucoceles...pdfapplication/pdf3926291https://www.arca.fiocruz.br/bitstream/icict/8935/2/Conceicao%20JG%20Oral%20mucoceles...pdf5131ed774a72acdb20b19373809720a6MD52TEXTConceicao JG Oral mucoceles...pdf.txtConceicao JG Oral mucoceles...pdf.txtExtracted texttext/plain40106https://www.arca.fiocruz.br/bitstream/icict/8935/3/Conceicao%20JG%20Oral%20mucoceles...pdf.txt50513162120e940bc262d098b053aa62MD53icict/89352023-03-15 14:33:01.396oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:01Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Oral mucoceles: a clinical, histopathological and immunohistochemical study. |
title |
Oral mucoceles: a clinical, histopathological and immunohistochemical study. |
spellingShingle |
Oral mucoceles: a clinical, histopathological and immunohistochemical study. Conceição, Jamile Gomes Oral mucoceles Histopathology Myxoglobulosis Immunohistochemistry |
title_short |
Oral mucoceles: a clinical, histopathological and immunohistochemical study. |
title_full |
Oral mucoceles: a clinical, histopathological and immunohistochemical study. |
title_fullStr |
Oral mucoceles: a clinical, histopathological and immunohistochemical study. |
title_full_unstemmed |
Oral mucoceles: a clinical, histopathological and immunohistochemical study. |
title_sort |
Oral mucoceles: a clinical, histopathological and immunohistochemical study. |
author |
Conceição, Jamile Gomes |
author_facet |
Conceição, Jamile Gomes Gurgel, Clarissa Araújo Silva Ramos, Eduardo Antônio Gonçalves Xavier, Flávia Caló De Aquino Salesa, Caroline Brandi Schlaepfer Cangussú, Maria Cristina Teixeira Cury, Patrícia Ramos Ramalho, Luciana Maria Pedreira Santos, Jean Nunes dos |
author_role |
author |
author2 |
Gurgel, Clarissa Araújo Silva Ramos, Eduardo Antônio Gonçalves Xavier, Flávia Caló De Aquino Salesa, Caroline Brandi Schlaepfer Cangussú, Maria Cristina Teixeira Cury, Patrícia Ramos Ramalho, Luciana Maria Pedreira Santos, Jean Nunes dos |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Conceição, Jamile Gomes Gurgel, Clarissa Araújo Silva Ramos, Eduardo Antônio Gonçalves Xavier, Flávia Caló De Aquino Salesa, Caroline Brandi Schlaepfer Cangussú, Maria Cristina Teixeira Cury, Patrícia Ramos Ramalho, Luciana Maria Pedreira Santos, Jean Nunes dos |
dc.subject.en.pt_BR.fl_str_mv |
Oral mucoceles Histopathology Myxoglobulosis Immunohistochemistry |
topic |
Oral mucoceles Histopathology Myxoglobulosis Immunohistochemistry |
description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2014-11-21T14:05:53Z |
dc.date.available.fl_str_mv |
2014-11-21T14:05:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CONCEIÇÃO, J. G. et al. Oral mucoceles: a clinical, histopathological and immunohistochemical study. Acta Histochemica, v. 116, n. 1, p. 40-47, 2014. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/8935 |
dc.identifier.issn.none.fl_str_mv |
1618-0372 |
dc.identifier.doi.none.fl_str_mv |
dx.doi.org/10.1016/j.acthis.2013.04.015 |
identifier_str_mv |
CONCEIÇÃO, J. G. et al. Oral mucoceles: a clinical, histopathological and immunohistochemical study. Acta Histochemica, v. 116, n. 1, p. 40-47, 2014. 1618-0372 dx.doi.org/10.1016/j.acthis.2013.04.015 |
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https://www.arca.fiocruz.br/handle/icict/8935 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Elsevier |
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Elsevier |
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