Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation

Detalhes bibliográficos
Autor(a) principal: Silva, Ana M. Moura da
Data de Publicação: 2016
Outros Autores: Almeida, Michelle T., Portes Junior, José A., Nicolau, Carolina A., Gomes Neto, Francisco, Valente, Richard H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16579
Resumo: Instituto Butantan. Laboratório de Imunopatologia. São Paulo, SP, Brasil.
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spelling Silva, Ana M. Moura daAlmeida, Michelle T.Portes Junior, José A.Nicolau, Carolina A.Gomes Neto, FranciscoValente, Richard H.2016-12-27T14:51:43Z2016-12-27T14:51:43Z2016SILVA, Ana M. Moura da; et al. Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation. Toxins, v.8, n.183, 15p, 2016.2072-6651https://www.arca.fiocruz.br/handle/icict/1657910.3390/toxins8060183engMDPIHemorragiaInibidor da enzimaVeneno de cobraMetaloproteinasesnake venommetalloproteinasepost-translational processingenzyme inhibitorhemorrhageProcessing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Butantan. Laboratório de Imunopatologia. São Paulo, SP, Brasil.Instituto Butantan. Laboratório de Imunopatologia. São Paulo, SP, Brasil.Instituto Butantan. Laboratório de Imunopatologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil.Snake venom metalloproteinases (SVMPs) are abundant in the venoms of vipers and rattlesnakes, playing important roles for the snake adaptation to different environments, and are related to most of the pathological effects of these venoms in human victims. The effectiveness of SVMPs is greatly due to their functional diversity, targeting important physiological proteins or receptors in different tissues and in the coagulation system. Functional diversity is often related to the genetic diversification of the snake venom. In this review, we discuss some published evidence that posit that processing and post-translational modifications are great contributors for the generation of functional diversity and for maintaining latency or inactivation of enzymes belonging to this relevant family of venom toxins.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16579/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALcarolina_nicolau_etal_IOC_2016.pdfcarolina_nicolau_etal_IOC_2016.pdfapplication/pdf1379420https://www.arca.fiocruz.br/bitstream/icict/16579/2/carolina_nicolau_etal_IOC_2016.pdff93cf450154ddf56658d64ea57272944MD52TEXTcarolina_nicolau_etal_IOC_2016.pdf.txtcarolina_nicolau_etal_IOC_2016.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation
title Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation
spellingShingle Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation
Silva, Ana M. Moura da
Hemorragia
Inibidor da enzima
Veneno de cobra
Metaloproteinase
snake venom
metalloproteinase
post-translational processing
enzyme inhibitor
hemorrhage
title_short Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation
title_full Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation
title_fullStr Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation
title_full_unstemmed Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation
title_sort Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation
author Silva, Ana M. Moura da
author_facet Silva, Ana M. Moura da
Almeida, Michelle T.
Portes Junior, José A.
Nicolau, Carolina A.
Gomes Neto, Francisco
Valente, Richard H.
author_role author
author2 Almeida, Michelle T.
Portes Junior, José A.
Nicolau, Carolina A.
Gomes Neto, Francisco
Valente, Richard H.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Ana M. Moura da
Almeida, Michelle T.
Portes Junior, José A.
Nicolau, Carolina A.
Gomes Neto, Francisco
Valente, Richard H.
dc.subject.other.pt_BR.fl_str_mv Hemorragia
Inibidor da enzima
Veneno de cobra
Metaloproteinase
topic Hemorragia
Inibidor da enzima
Veneno de cobra
Metaloproteinase
snake venom
metalloproteinase
post-translational processing
enzyme inhibitor
hemorrhage
dc.subject.en.pt_BR.fl_str_mv snake venom
metalloproteinase
post-translational processing
enzyme inhibitor
hemorrhage
description Instituto Butantan. Laboratório de Imunopatologia. São Paulo, SP, Brasil.
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-12-27T14:51:43Z
dc.date.available.fl_str_mv 2016-12-27T14:51:43Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Ana M. Moura da; et al. Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation. Toxins, v.8, n.183, 15p, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16579
dc.identifier.issn.pt_BR.fl_str_mv 2072-6651
dc.identifier.doi.none.fl_str_mv 10.3390/toxins8060183
identifier_str_mv SILVA, Ana M. Moura da; et al. Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation. Toxins, v.8, n.183, 15p, 2016.
2072-6651
10.3390/toxins8060183
url https://www.arca.fiocruz.br/handle/icict/16579
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/16579/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/16579/2/carolina_nicolau_etal_IOC_2016.pdf
https://www.arca.fiocruz.br/bitstream/icict/16579/3/carolina_nicolau_etal_IOC_2016.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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