Phytochemical characterization and inhibition of Candida sp. by the essential oil of Baccharis trimera (Less.) DC

Detalhes bibliográficos
Autor(a) principal: Silva, Taís Gusmão da
Data de Publicação: 2021
Outros Autores: Silva, Josefa Carolaine Pereira da, Carneiro, Joara Nályda Pereira, Amaral, Wanderlei do, Deschamps, Cícero, Araújo, Jenifer Priscila de, Costa, José Galberto Martins da, Almeida, Waltécio de Oliveira, Silva, Luiz Everson da, Coutinho1, Henrique Douglas Melo, Ribeiro Filho, Jaime, Braga, Maria Flaviana Bezerra Morais
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50489
Resumo: Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico, FUNCAP for financial support.
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spelling Silva, Taís Gusmão daSilva, Josefa Carolaine Pereira daCarneiro, Joara Nályda PereiraAmaral, Wanderlei doDeschamps, CíceroAraújo, Jenifer Priscila deCosta, José Galberto Martins daAlmeida, Waltécio de OliveiraSilva, Luiz Everson daCoutinho1, Henrique Douglas MeloRibeiro Filho, JaimeBraga, Maria Flaviana Bezerra Morais2021-12-20T18:01:17Z2021-12-20T18:01:17Z2021SILVA, Taís Gusmão da et al. Phytochemical characterization and inhibition of Candida sp. by the essential oil of Baccharis trimera (Less.) DC. Archives of Microbiology, 2021.0302-8933https://www.arca.fiocruz.br/handle/icict/5048910.1007/s00203-021-02304-8Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico, FUNCAP for financial support.Universidade Regional do Cariri. Department of Biological Chemistry. Crato, CE, Brasil.Universidade Regional do Cariri. Department of Biological Chemistry. Crato, CE, Brasil.Universidade Regional do Cariri. Department of Biological Chemistry. Crato, CE, Brasil.Universidade Federal do Paraná. Curitiba, PR, Brasil.Universidade Federal do Paraná. Curitiba, PR, Brasil.Universidade Federal do Paraná. Curitiba, PR, Brasil.Universidade Regional do Cariri. Department of Biological Chemistry. Crato, CE, Brasil.Universidade Regional do Cariri. Department of Biological Chemistry. Crato, CE, Brasil.Universidade Federal do Paraná. Curitiba, PR, Brasil.Universidade Regional do Cariri. Department of Biological Chemistry. Crato, CE, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Universidade Regional do Cariri. Department of Biological Chemistry. Crato, CE, Brasil.This study aimed to investigate the chemical composition and antifungal potential of the essential oil of Baccharis trimera (Less.) DC. against Candida strains. The half maximal inhibitory concentration ( IC50) was assessed by the microdilution method using the essential oil at a concentration range of 8192 to 8 μg/mL. The minimum fungicide concentration (MFC) was determined by subculture in solid medium. The ability of the essential oil to modulate the activity of antifungals was determined in wells treated simultaneously with the oil at a subinhibitory concentration (MFC/16) and fluconazole (FCZ). The fungal morphology was analyzed by microscopy. Gas chromatography coupled with mass spectrometry (GC/MS) was used to identify the chemical composition. The essential oil presented an CI50 of 11.24 and 1.45 μg/mL, which was found to potentiate the effect of FCZ against Candida albicans. On the other hand, this combined treatment resulted in antagonism against Candida tropicalis and no evident modulation against Candida krusei was observed. The essential oil significantly inhibited hyphae growth. However, with a MFC ≥ 16,384 μg/mL, it is assumed that it has a fungistatic action. The antifungal properties demonstrated in this study might be related to the presence of sesquiterpenes and monoterpenes, and the interaction between them. In conclusion, Baccharis trimera showed promising anti-Candida effects, in addition to potentiating the activity of FCZ against Candida albicans, affecting its morphological transition. Therefore, this species constitutes a source of chemical compounds with the potential to be used in the combat of fungal infections.engSpringerBaccharisTerpenosÓleos essenciaisCandidaBaccharis trimera ·Terpenes ·Essential oils ·Anti-Candida effectPhytochemical characterization and inhibition of Candida sp. by the essential oil of Baccharis trimera (Less.) DCinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/50489/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALSilva, Thaiaas Gusmao Phytochemical....pdfSilva, Thaiaas Gusmao Phytochemical....pdfapplication/pdf1195191https://www.arca.fiocruz.br/bitstream/icict/50489/2/Silva%2c%20Thaiaas%20Gusmao%20Phytochemical....pdfe33b300461b906dadb9898fc36c9a6e1MD52icict/504892023-03-15 14:34:33.949oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:33Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.pt_BR.fl_str_mv Phytochemical characterization and inhibition of Candida sp. by the essential oil of Baccharis trimera (Less.) DC
title Phytochemical characterization and inhibition of Candida sp. by the essential oil of Baccharis trimera (Less.) DC
spellingShingle Phytochemical characterization and inhibition of Candida sp. by the essential oil of Baccharis trimera (Less.) DC
Silva, Taís Gusmão da
Baccharis
Terpenos
Óleos essenciais
Candida
Baccharis trimera ·
Terpenes ·
Essential oils ·
Anti-Candida effect
title_short Phytochemical characterization and inhibition of Candida sp. by the essential oil of Baccharis trimera (Less.) DC
title_full Phytochemical characterization and inhibition of Candida sp. by the essential oil of Baccharis trimera (Less.) DC
title_fullStr Phytochemical characterization and inhibition of Candida sp. by the essential oil of Baccharis trimera (Less.) DC
title_full_unstemmed Phytochemical characterization and inhibition of Candida sp. by the essential oil of Baccharis trimera (Less.) DC
title_sort Phytochemical characterization and inhibition of Candida sp. by the essential oil of Baccharis trimera (Less.) DC
author Silva, Taís Gusmão da
author_facet Silva, Taís Gusmão da
Silva, Josefa Carolaine Pereira da
Carneiro, Joara Nályda Pereira
Amaral, Wanderlei do
Deschamps, Cícero
Araújo, Jenifer Priscila de
Costa, José Galberto Martins da
Almeida, Waltécio de Oliveira
Silva, Luiz Everson da
Coutinho1, Henrique Douglas Melo
Ribeiro Filho, Jaime
Braga, Maria Flaviana Bezerra Morais
author_role author
author2 Silva, Josefa Carolaine Pereira da
Carneiro, Joara Nályda Pereira
Amaral, Wanderlei do
Deschamps, Cícero
Araújo, Jenifer Priscila de
Costa, José Galberto Martins da
Almeida, Waltécio de Oliveira
Silva, Luiz Everson da
Coutinho1, Henrique Douglas Melo
Ribeiro Filho, Jaime
Braga, Maria Flaviana Bezerra Morais
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Taís Gusmão da
Silva, Josefa Carolaine Pereira da
Carneiro, Joara Nályda Pereira
Amaral, Wanderlei do
Deschamps, Cícero
Araújo, Jenifer Priscila de
Costa, José Galberto Martins da
Almeida, Waltécio de Oliveira
Silva, Luiz Everson da
Coutinho1, Henrique Douglas Melo
Ribeiro Filho, Jaime
Braga, Maria Flaviana Bezerra Morais
dc.subject.other.pt_BR.fl_str_mv Baccharis
Terpenos
Óleos essenciais
Candida
topic Baccharis
Terpenos
Óleos essenciais
Candida
Baccharis trimera ·
Terpenes ·
Essential oils ·
Anti-Candida effect
dc.subject.en.pt_BR.fl_str_mv Baccharis trimera ·
Terpenes ·
Essential oils ·
Anti-Candida effect
description Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico, FUNCAP for financial support.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-20T18:01:17Z
dc.date.available.fl_str_mv 2021-12-20T18:01:17Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Taís Gusmão da et al. Phytochemical characterization and inhibition of Candida sp. by the essential oil of Baccharis trimera (Less.) DC. Archives of Microbiology, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50489
dc.identifier.issn.pt_BR.fl_str_mv 0302-8933
dc.identifier.eissn.none.fl_str_mv 10.1007/s00203-021-02304-8
identifier_str_mv SILVA, Taís Gusmão da et al. Phytochemical characterization and inhibition of Candida sp. by the essential oil of Baccharis trimera (Less.) DC. Archives of Microbiology, 2021.
0302-8933
10.1007/s00203-021-02304-8
url https://www.arca.fiocruz.br/handle/icict/50489
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50489/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50489/2/Silva%2c%20Thaiaas%20Gusmao%20Phytochemical....pdf
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