Current Status of the Sm14/GLA-SE Schistosomiasis Vaccine: Overcoming Barriers and Paradigms towards the First Anti-Parasitic Human(itarian) Vaccine

Detalhes bibliográficos
Autor(a) principal: Tendler, Miriam
Data de Publicação: 2018
Outros Autores: Almeida, Marília S., Vilar, Monica M., Pinto, Patrícia M., Sousa, Gabriel Limaverde
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31414
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Esquistossomose Experimental. Rio de Janeiro, RJ, Brasil.
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spelling Tendler, MiriamAlmeida, Marília S.Vilar, Monica M.Pinto, Patrícia M.Sousa, Gabriel Limaverde2019-02-05T12:05:59Z2019-02-05T12:05:59Z2018TENDLER, Miriam et al. Current Status of the Sm14/GLA-SE Schistosomiasis Vaccine: Overcoming Barriers and Paradigms towards the First Anti-Parasitic Human (itarian) Vaccine. Tropical Medicine and Infectious Disease, v.3, n.121, p. 1-10, 2018.2414-6366https://www.arca.fiocruz.br/handle/icict/3141410.3390/tropicalmed3040121engMDPIEsquistossomoseVacinaSchistosomiasisVaccineSm14FABPCurrent Status of the Sm14/GLA-SE Schistosomiasis Vaccine: Overcoming Barriers and Paradigms towards the First Anti-Parasitic Human(itarian) Vaccineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Esquistossomose Experimental. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Esquistossomose Experimental. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Esquistossomose Experimental. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Esquistossomose Experimental. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Esquistossomose Experimental. Rio de Janeiro, RJ, Brasil.Schistosomiasis, a disease historically associated with poverty, lack of sanitation and social inequality, is a chronic, debilitating parasitic infection, affecting hundreds of millions of people in endemic countries. Although chemotherapy is capable of reducing morbidity in humans, rapid re-infection demonstrates that the impact of drug treatment on transmission control or disease elimination is marginal. In addition, despite more than two decades of well-executed control activities based on large-scale chemotherapy, the disease is expanding in many areas including Brazil. The development of the Sm14/GLA-SE schistosomiasis vaccine is an emblematic, open knowledge innovation that has successfully completed phase I and phase IIa clinical trials, with Phase II/III trials underway in the African continent, to be followed by further trials in Brazil. The discovery and experimental phases of the development of this vaccine gathered a robust collection of data that strongly supports the ongoing clinical phase. This paper reviews the development of the Sm14 vaccine, formulated with glucopyranosyl lipid A (GLA-SE), from the initial experimental developments to clinical trials including the current status of phase II studies.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALgabrielimaverde_souza_etal_IOC_2018.pdfgabrielimaverde_souza_etal_IOC_2018.pdfapplication/pdf693038https://www.arca.fiocruz.br/bitstream/icict/31414/2/gabrielimaverde_souza_etal_IOC_2018.pdf0e2243932e49414af1f6893eb8fabd02MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31414/3/license.txt5a560609d32a3863062d77ff32785d58MD53TEXTgabrielimaverde_souza_etal_IOC_2018.pdf.txtgabrielimaverde_souza_etal_IOC_2018.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Current Status of the Sm14/GLA-SE Schistosomiasis Vaccine: Overcoming Barriers and Paradigms towards the First Anti-Parasitic Human(itarian) Vaccine
title Current Status of the Sm14/GLA-SE Schistosomiasis Vaccine: Overcoming Barriers and Paradigms towards the First Anti-Parasitic Human(itarian) Vaccine
spellingShingle Current Status of the Sm14/GLA-SE Schistosomiasis Vaccine: Overcoming Barriers and Paradigms towards the First Anti-Parasitic Human(itarian) Vaccine
Tendler, Miriam
Esquistossomose
Vacina
Schistosomiasis
Vaccine
Sm14
FABP
title_short Current Status of the Sm14/GLA-SE Schistosomiasis Vaccine: Overcoming Barriers and Paradigms towards the First Anti-Parasitic Human(itarian) Vaccine
title_full Current Status of the Sm14/GLA-SE Schistosomiasis Vaccine: Overcoming Barriers and Paradigms towards the First Anti-Parasitic Human(itarian) Vaccine
title_fullStr Current Status of the Sm14/GLA-SE Schistosomiasis Vaccine: Overcoming Barriers and Paradigms towards the First Anti-Parasitic Human(itarian) Vaccine
title_full_unstemmed Current Status of the Sm14/GLA-SE Schistosomiasis Vaccine: Overcoming Barriers and Paradigms towards the First Anti-Parasitic Human(itarian) Vaccine
title_sort Current Status of the Sm14/GLA-SE Schistosomiasis Vaccine: Overcoming Barriers and Paradigms towards the First Anti-Parasitic Human(itarian) Vaccine
author Tendler, Miriam
author_facet Tendler, Miriam
Almeida, Marília S.
Vilar, Monica M.
Pinto, Patrícia M.
Sousa, Gabriel Limaverde
author_role author
author2 Almeida, Marília S.
Vilar, Monica M.
Pinto, Patrícia M.
Sousa, Gabriel Limaverde
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Tendler, Miriam
Almeida, Marília S.
Vilar, Monica M.
Pinto, Patrícia M.
Sousa, Gabriel Limaverde
dc.subject.other.pt_BR.fl_str_mv Esquistossomose
Vacina
topic Esquistossomose
Vacina
Schistosomiasis
Vaccine
Sm14
FABP
dc.subject.en.pt_BR.fl_str_mv Schistosomiasis
Vaccine
Sm14
FABP
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Esquistossomose Experimental. Rio de Janeiro, RJ, Brasil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-02-05T12:05:59Z
dc.date.available.fl_str_mv 2019-02-05T12:05:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TENDLER, Miriam et al. Current Status of the Sm14/GLA-SE Schistosomiasis Vaccine: Overcoming Barriers and Paradigms towards the First Anti-Parasitic Human (itarian) Vaccine. Tropical Medicine and Infectious Disease, v.3, n.121, p. 1-10, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31414
dc.identifier.issn.pt_BR.fl_str_mv 2414-6366
dc.identifier.doi.none.fl_str_mv 10.3390/tropicalmed3040121
identifier_str_mv TENDLER, Miriam et al. Current Status of the Sm14/GLA-SE Schistosomiasis Vaccine: Overcoming Barriers and Paradigms towards the First Anti-Parasitic Human (itarian) Vaccine. Tropical Medicine and Infectious Disease, v.3, n.121, p. 1-10, 2018.
2414-6366
10.3390/tropicalmed3040121
url https://www.arca.fiocruz.br/handle/icict/31414
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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