Impairment of the humoral and CD4(+) T cell responses in HTLV-1-infected individuals immunized with tetanus toxoid
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16600 |
Resumo: | CNPq (Brazilian Council for Scientific and Technological Development) and the NIH Training Grant R01 AI079238A (EMC). |
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Souza, AnselmoSantos, SilvaneCarvalho, Lucas PGrassi, Maria Fernanda RiosCarvalho Filho, Edgar Marcelino2016-12-29T14:25:03Z2016-12-29T14:25:03Z2016SOUZA, A. et al. Impairment of the humoral and CD4(+) T cell responses in HTLV-1-infected individuals immunized with tetanus toxoid. Human Immunology, v. 77, p. 674–681, 2016.0198-8859https://www.arca.fiocruz.br/handle/icict/1660010.1016/j.humimm.2016.06.003CNPq (Brazilian Council for Scientific and Technological Development) and the NIH Training Grant R01 AI079238A (EMC).Federal University of Bahia. Hospital Professor Edgard Santos. Immunology Service. Salvador, BA, Brasil / National Institute of Science and Technology – Tropical Diseases. INCT-DT. CNPq. BrazilFederal University of Bahia. Hospital Professor Edgard Santos. Immunology Service. Salvador, BA, Brasil / State University of Feira de Santana. Biological Science Department. Feira de Santana, BA, Brasil / National Institute of Science and Technology – Tropical Diseases. INCT-DT. CNPq. BrazilFederal University of Bahia. Hospital Professor Edgard Santos. Immunology Service. Salvador, BA, BrasilBahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFederal University of Bahia. Hospital Professor Edgard Santos. Immunology Service. Salvador, BA, Brasil / National Institute of Science and Technology – Tropical Diseases. INCT-DT. CNPq. Brazil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilT cells from HTLV-1-infected individuals have a decreased ability to proliferate after stimulation with recall antigens. This abnormality may be due to the production of regulatory cytokine or a dysfunctional antigen presentation. The aims of this study were to evaluate the antibody production and cytokine expression by lymphocytes before and after immunization with tetanus toxoid (TT) and to evaluate the immune response of monocytes after stimulation with TT and frequency of dendritic cells (DC) subsets. HTLV-1 carriers (HC) and uninfected controls (UC) with negative serology for TT were immunized with TT, and the antibody titers were determined by ELISA as well as the cell activation markers expression by monocytes. The frequencies of DC subsets were determined by flow cytometry. Following immunization, the IgG anti-TT titers and the frequency of CD4(+) T cells expressing IFN-γ, TNF-α and IL-10 in response to TT were lower in the HC than in the UC. Additionally, monocytes from HC did not exhibit increased HLA-DR expression after stimulation with TT, and presented low numbers of DC subsets, therefore, it's necessary to perform functional studies with antigen-presenting cells. Collectively, our finding suggests that HC present an impairment of the humoral and CD4(+) T cell immune responses after vaccination.engElsevierHTLV-1AnticorpoCytokinesAntigenosInfecçãoHTLV-1AntibodyCytokinesAntigen-presenting cellsRecall antigenImpairment of the humoral and CD4(+) T cell responses in HTLV-1-infected individuals immunized with tetanus toxoidinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16600/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSouza A Impairment of the ....pdfSouza A Impairment of the ....pdfapplication/pdf1436098https://www.arca.fiocruz.br/bitstream/icict/16600/2/Souza%20A%20Impairment%20of%20the%20....pdfc429cbd88619e52c9f61f30a09fa679dMD52TEXTSouza A Impairment of the 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| dc.title.pt_BR.fl_str_mv |
Impairment of the humoral and CD4(+) T cell responses in HTLV-1-infected individuals immunized with tetanus toxoid |
| title |
Impairment of the humoral and CD4(+) T cell responses in HTLV-1-infected individuals immunized with tetanus toxoid |
| spellingShingle |
Impairment of the humoral and CD4(+) T cell responses in HTLV-1-infected individuals immunized with tetanus toxoid Souza, Anselmo HTLV-1 Anticorpo Cytokines Antigenos Infecção HTLV-1 Antibody Cytokines Antigen-presenting cells Recall antigen |
| title_short |
Impairment of the humoral and CD4(+) T cell responses in HTLV-1-infected individuals immunized with tetanus toxoid |
| title_full |
Impairment of the humoral and CD4(+) T cell responses in HTLV-1-infected individuals immunized with tetanus toxoid |
| title_fullStr |
Impairment of the humoral and CD4(+) T cell responses in HTLV-1-infected individuals immunized with tetanus toxoid |
| title_full_unstemmed |
Impairment of the humoral and CD4(+) T cell responses in HTLV-1-infected individuals immunized with tetanus toxoid |
| title_sort |
Impairment of the humoral and CD4(+) T cell responses in HTLV-1-infected individuals immunized with tetanus toxoid |
| author |
Souza, Anselmo |
| author_facet |
Souza, Anselmo Santos, Silvane Carvalho, Lucas P Grassi, Maria Fernanda Rios Carvalho Filho, Edgar Marcelino |
| author_role |
author |
| author2 |
Santos, Silvane Carvalho, Lucas P Grassi, Maria Fernanda Rios Carvalho Filho, Edgar Marcelino |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Souza, Anselmo Santos, Silvane Carvalho, Lucas P Grassi, Maria Fernanda Rios Carvalho Filho, Edgar Marcelino |
| dc.subject.other.pt_BR.fl_str_mv |
HTLV-1 Anticorpo Cytokines Antigenos Infecção |
| topic |
HTLV-1 Anticorpo Cytokines Antigenos Infecção HTLV-1 Antibody Cytokines Antigen-presenting cells Recall antigen |
| dc.subject.en.pt_BR.fl_str_mv |
HTLV-1 Antibody Cytokines Antigen-presenting cells Recall antigen |
| description |
CNPq (Brazilian Council for Scientific and Technological Development) and the NIH Training Grant R01 AI079238A (EMC). |
| publishDate |
2016 |
| dc.date.accessioned.fl_str_mv |
2016-12-29T14:25:03Z |
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2016-12-29T14:25:03Z |
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2016 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
SOUZA, A. et al. Impairment of the humoral and CD4(+) T cell responses in HTLV-1-infected individuals immunized with tetanus toxoid. Human Immunology, v. 77, p. 674–681, 2016. |
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https://www.arca.fiocruz.br/handle/icict/16600 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0198-8859 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.humimm.2016.06.003 |
| identifier_str_mv |
SOUZA, A. et al. Impairment of the humoral and CD4(+) T cell responses in HTLV-1-infected individuals immunized with tetanus toxoid. Human Immunology, v. 77, p. 674–681, 2016. 0198-8859 10.1016/j.humimm.2016.06.003 |
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https://www.arca.fiocruz.br/handle/icict/16600 |
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eng |
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eng |
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openAccess |
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Elsevier |
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Elsevier |
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