C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23599 |
Resumo: | Fondazione Ri.MED. Palermo, Italy / University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA. |
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Douradinha, BrunoMcBurney, Sean P.Melo, Klecia M. Soares deSmith, Amanda P.Krishna, Neel K.Barratt-Boyes, Simon M.Evans, Jared D.Nascimento, Eduardo J. M.Marques, Ernesto T. A.2017-12-11T13:34:26Z2017-12-11T13:34:26Z2014DOURADINHA, B. et al. C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells. Virus Research, v. 179, p. 231–234, jan. 2014.1872-7492https://www.arca.fiocruz.br/handle/icict/2359910.1016/j.virusres.2013.11.007engElsevierDengueFebre Hemorrágica da DengueFebre de DengueC1qCaminho de Complemento ClássicoPersistência ViralDengueDengue Hemorrhagic FeverDengue FeverC1qClassical Complement PathwayViral PersistenceComplemento C1qmetabolismoVírus da DenguefisiologiaDenguegenéticaMediadores da InflamaçãoimunologiaAntígenos CD14genéticaAntígenos CD14imunologiaAntígenos CD86genéticaAntígenos CD86imunologiaMoléculas de Adesão CelulargenéticaLinhagem CelularhumanosComplemento C1qimunologiaDenguemetabolismoDenguevirologiaVírus da DengueclassificaçãoLectinas Tipo CLigação ProteicaReceptores de Superfície CelularProteínas do Envelope ViralC1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFondazione Ri.MED. Palermo, Italy / University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA.University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA.University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil.University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA.Eastern Virginia Medical School. Department of Microbiology and Molecular Cell Biology. Norfolk, Virginia, USA.University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA / University of Pittsburgh. Graduate School of Public Health. Department of Infectious Diseases and Microbiology. Pittsburgh, USA.University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA / University of Pittsburgh. School of Medicine. Department of Microbiology and Molecular Genetics. Pittsburgh, USA.University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA / University of Pittsburgh. Graduate School of Public Health. Department of Infectious Diseases and Microbiology. Pittsburgh, USA.University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil / University of Pittsburgh. Graduate School of Public Health. Department of Infectious Diseases and Microbiology. Pittsburgh, USA.Dengue virus infection elicits a spectrum of clinical presentations ranging from asymptomatic to severe disease. The mechanisms leading to severe dengue are not known, however it has been reported that the complement system is hyper-activated in severe dengue. Screening of complement proteins demonstrated that C1q, a pattern recognition molecule, can bind directly to dengue virus envelope protein and to whole dengue virus serotype 2. Incubation of dengue virus serotype 2 with C1q prior to infection of THP-1 cells led to decreased virus infectivity and modulation of mRNA expression of immunoregulatory molecules suggesting reduced inflammatory responses.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83092https://www.arca.fiocruz.br/bitstream/icict/23599/1/license.txt447f2497af1ef5cf99b5c07f6fa18dceMD51ORIGINALart. C1q binding - douradinha.pdfart. C1q binding - douradinha.pdfapplication/pdf356297https://www.arca.fiocruz.br/bitstream/icict/23599/2/art.%20C1q%20binding%20-%20douradinha.pdf40c2f62c2a58ba25cf310346ca16f238MD52TEXTart. C1q binding - douradinha.pdf.txtart. 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| dc.title.pt_BR.fl_str_mv |
C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells |
| title |
C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells |
| spellingShingle |
C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells Douradinha, Bruno Dengue Febre Hemorrágica da Dengue Febre de Dengue C1q Caminho de Complemento Clássico Persistência Viral Dengue Dengue Hemorrhagic Fever Dengue Fever C1q Classical Complement Pathway Viral Persistence Complemento C1q metabolismo Vírus da Dengue fisiologia Dengue genética Mediadores da Inflamação imunologia Antígenos CD14 genética Antígenos CD14 imunologia Antígenos CD86 genética Antígenos CD86 imunologia Moléculas de Adesão Celular genética Linhagem Celular humanos Complemento C1q imunologia Dengue metabolismo Dengue virologia Vírus da Dengue classificação Lectinas Tipo C Ligação Proteica Receptores de Superfície Celular Proteínas do Envelope Viral |
| title_short |
C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells |
| title_full |
C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells |
| title_fullStr |
C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells |
| title_full_unstemmed |
C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells |
| title_sort |
C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells |
| author |
Douradinha, Bruno |
| author_facet |
Douradinha, Bruno McBurney, Sean P. Melo, Klecia M. Soares de Smith, Amanda P. Krishna, Neel K. Barratt-Boyes, Simon M. Evans, Jared D. Nascimento, Eduardo J. M. Marques, Ernesto T. A. |
| author_role |
author |
| author2 |
McBurney, Sean P. Melo, Klecia M. Soares de Smith, Amanda P. Krishna, Neel K. Barratt-Boyes, Simon M. Evans, Jared D. Nascimento, Eduardo J. M. Marques, Ernesto T. A. |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Douradinha, Bruno McBurney, Sean P. Melo, Klecia M. Soares de Smith, Amanda P. Krishna, Neel K. Barratt-Boyes, Simon M. Evans, Jared D. Nascimento, Eduardo J. M. Marques, Ernesto T. A. |
| dc.subject.other.pt_BR.fl_str_mv |
Dengue Febre Hemorrágica da Dengue Febre de Dengue C1q Caminho de Complemento Clássico Persistência Viral |
| topic |
Dengue Febre Hemorrágica da Dengue Febre de Dengue C1q Caminho de Complemento Clássico Persistência Viral Dengue Dengue Hemorrhagic Fever Dengue Fever C1q Classical Complement Pathway Viral Persistence Complemento C1q metabolismo Vírus da Dengue fisiologia Dengue genética Mediadores da Inflamação imunologia Antígenos CD14 genética Antígenos CD14 imunologia Antígenos CD86 genética Antígenos CD86 imunologia Moléculas de Adesão Celular genética Linhagem Celular humanos Complemento C1q imunologia Dengue metabolismo Dengue virologia Vírus da Dengue classificação Lectinas Tipo C Ligação Proteica Receptores de Superfície Celular Proteínas do Envelope Viral |
| dc.subject.en.pt_BR.fl_str_mv |
Dengue Dengue Hemorrhagic Fever Dengue Fever C1q Classical Complement Pathway Viral Persistence |
| dc.subject.decs.pt_BR.fl_str_mv |
Complemento C1q metabolismo Vírus da Dengue fisiologia Dengue genética Mediadores da Inflamação imunologia Antígenos CD14 genética Antígenos CD14 imunologia Antígenos CD86 genética Antígenos CD86 imunologia Moléculas de Adesão Celular genética Linhagem Celular humanos Complemento C1q imunologia Dengue metabolismo Dengue virologia Vírus da Dengue classificação Lectinas Tipo C Ligação Proteica Receptores de Superfície Celular Proteínas do Envelope Viral |
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Fondazione Ri.MED. Palermo, Italy / University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA. |
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2014 |
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2014 |
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2017-12-11T13:34:26Z |
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2017-12-11T13:34:26Z |
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info:eu-repo/semantics/article |
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DOURADINHA, B. et al. C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells. Virus Research, v. 179, p. 231–234, jan. 2014. |
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https://www.arca.fiocruz.br/handle/icict/23599 |
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1872-7492 |
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10.1016/j.virusres.2013.11.007 |
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DOURADINHA, B. et al. C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells. Virus Research, v. 179, p. 231–234, jan. 2014. 1872-7492 10.1016/j.virusres.2013.11.007 |
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Elsevier |
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