Trends in AIDS-defining opportunistic illnesses incidence over 25 Years in Rio de Janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Coelho, Lara Esteves
Data de Publicação: 2014
Outros Autores: Cardoso, Sandra Wagner, Amancio, Rodrigo Teixeira, Moreira, Ronaldo Ismério, Campos, Dayse Pereira, Veloso, Valdiléa G., Grinsztejn, Beatriz, Luz, Paula Mendes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1371/journal.pone.0098666
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10279
Resumo: CNPq, FAPERJ
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spelling Coelho, Lara EstevesCardoso, Sandra WagnerAmancio, Rodrigo TeixeiraMoreira, Ronaldo IsmérioCampos, Dayse PereiraVeloso, Valdiléa G.Grinsztejn, BeatrizLuz, Paula Mendes2015-05-11T15:39:03Z2015-05-11T15:39:03Z2014COELHO, Lara Esteves et al. Trends in AIDS-defining opportunistic illnesses incidence over 25 Years in Rio de Janeiro, Brazil. Plos One, v. 9, n. 6, p. 1-8, June 2014.1932-6203https://www.arca.fiocruz.br/handle/icict/1027910.1371/journal.pone.00986661932-6203CNPq, FAPERJFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Objectives: To assess the temporal trends in incidence of AIDS-defining opportunistic illnesses in an urban cohort of a middle-income country. Methods: HIV infected patients aged $18 years at cohort entry were included in this analysis. We calculated incidence rates per 1000 persons-years of observation for the first opportunistic illness presented after cohort enrollment, from 1987 to 2012. Trends for overall and specific opportunistic illnesses were tested and incidence rate ratios for the most recent calendar period were calculated as the ratio between the incidence rate observed in the most recent period of the study (2009–2012) and the incidence rate observed in first period of the study (1987–1990). Results: Overall, 3378 patients were included in this analysis; of which 1119 (33%) patients presented an opportunistic illness during follow up. Incidence rates of all opportunistic illnesses decreased over time, and the overall opportunistic illness incidence rates fell from 295.4/1000 persons-years in 1987–1990 to 34.6/1000 persons-years in 2009–2012. Tuberculosis, esophageal candidiasis, cerebral toxoplasmosis and Pneumocystis jirovecii pneumonia were the most incident opportunistic illnesses in the cohort. Tuberculosis had the highest incidence rate in the study period. The peak in tuberculosis incidence occurred in 1991–1993 (80.8/1000 persons-years). Cerebral toxoplasmosis was the third most incident opportunistic illness in the study, with a peak of incidence of 43.6/1000 persons-year in 1987–1990. Conclusions: All opportunistic illnesses incidence rates decreased over the years but they still occur in an unacceptable frequency. Tuberculosis co-infection among HIV-infected persists as an important challenge for health care professionals and policy makers in our setting. Impressively high rates of cerebral toxoplasmosis were found suggesting that its incidence among HIV-infected is linked to the high prevalence of Toxoplasma gondii infection in the general population.engPublic Library of ScienceTrends in AIDS-defining opportunistic illnesses incidence over 25 Years in Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAcquired Immunodeficiency SyndromeOpportunistic InfectionsTuberculosisToxoplasmosis, CerebralToxoplasmaPneumocystis jiroveciiCandidiasisSíndrome de Imunodeficiência AdquiridaInfecções OportunistasTuberculoseToxoplasmose CerebralToxoplasmaPneumocystis jiroveciiCandidíaseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10279/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALTrends in AIDS-defining 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dc.title.pt_BR.fl_str_mv Trends in AIDS-defining opportunistic illnesses incidence over 25 Years in Rio de Janeiro, Brazil
title Trends in AIDS-defining opportunistic illnesses incidence over 25 Years in Rio de Janeiro, Brazil
spellingShingle Trends in AIDS-defining opportunistic illnesses incidence over 25 Years in Rio de Janeiro, Brazil
Coelho, Lara Esteves
Acquired Immunodeficiency Syndrome
Opportunistic Infections
Tuberculosis
Toxoplasmosis, Cerebral
Toxoplasma
Pneumocystis jirovecii
Candidiasis
Síndrome de Imunodeficiência Adquirida
Infecções Oportunistas
Tuberculose
Toxoplasmose Cerebral
Toxoplasma
Pneumocystis jirovecii
Candidíase
title_short Trends in AIDS-defining opportunistic illnesses incidence over 25 Years in Rio de Janeiro, Brazil
title_full Trends in AIDS-defining opportunistic illnesses incidence over 25 Years in Rio de Janeiro, Brazil
title_fullStr Trends in AIDS-defining opportunistic illnesses incidence over 25 Years in Rio de Janeiro, Brazil
title_full_unstemmed Trends in AIDS-defining opportunistic illnesses incidence over 25 Years in Rio de Janeiro, Brazil
title_sort Trends in AIDS-defining opportunistic illnesses incidence over 25 Years in Rio de Janeiro, Brazil
author Coelho, Lara Esteves
author_facet Coelho, Lara Esteves
Cardoso, Sandra Wagner
Amancio, Rodrigo Teixeira
Moreira, Ronaldo Ismério
Campos, Dayse Pereira
Veloso, Valdiléa G.
Grinsztejn, Beatriz
Luz, Paula Mendes
author_role author
author2 Cardoso, Sandra Wagner
Amancio, Rodrigo Teixeira
Moreira, Ronaldo Ismério
Campos, Dayse Pereira
Veloso, Valdiléa G.
Grinsztejn, Beatriz
Luz, Paula Mendes
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Coelho, Lara Esteves
Cardoso, Sandra Wagner
Amancio, Rodrigo Teixeira
Moreira, Ronaldo Ismério
Campos, Dayse Pereira
Veloso, Valdiléa G.
Grinsztejn, Beatriz
Luz, Paula Mendes
dc.subject.en.pt_BR.fl_str_mv Acquired Immunodeficiency Syndrome
Opportunistic Infections
Tuberculosis
Toxoplasmosis, Cerebral
Toxoplasma
Pneumocystis jirovecii
Candidiasis
topic Acquired Immunodeficiency Syndrome
Opportunistic Infections
Tuberculosis
Toxoplasmosis, Cerebral
Toxoplasma
Pneumocystis jirovecii
Candidiasis
Síndrome de Imunodeficiência Adquirida
Infecções Oportunistas
Tuberculose
Toxoplasmose Cerebral
Toxoplasma
Pneumocystis jirovecii
Candidíase
dc.subject.decs.pt_BR.fl_str_mv Síndrome de Imunodeficiência Adquirida
Infecções Oportunistas
Tuberculose
Toxoplasmose Cerebral
Toxoplasma
Pneumocystis jirovecii
Candidíase
description CNPq, FAPERJ
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-05-11T15:39:03Z
dc.date.available.fl_str_mv 2015-05-11T15:39:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv COELHO, Lara Esteves et al. Trends in AIDS-defining opportunistic illnesses incidence over 25 Years in Rio de Janeiro, Brazil. Plos One, v. 9, n. 6, p. 1-8, June 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10279
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0098666
dc.identifier.eissn.none.fl_str_mv 1932-6203
identifier_str_mv COELHO, Lara Esteves et al. Trends in AIDS-defining opportunistic illnesses incidence over 25 Years in Rio de Janeiro, Brazil. Plos One, v. 9, n. 6, p. 1-8, June 2014.
1932-6203
10.1371/journal.pone.0098666
url https://www.arca.fiocruz.br/handle/icict/10279
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
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