Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin

Detalhes bibliográficos
Autor(a) principal: Penido, Carmen
Data de Publicação: 2003
Outros Autores: Abreu, Adriana Vieira de, Bozza, Marcelo T., Faria Neto, Hugo Caire C., Bozza, Patrícia T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/41073
Resumo: Acesso aberto em 03/05/2020 - https://www.jimmunol.org/content/171/12/6788
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spelling Penido, CarmenAbreu, Adriana Vieira deBozza, Marcelo T.Faria Neto, Hugo Caire C.Bozza, Patrícia T.2020-05-03T18:42:02Z2020-05-03T18:42:02Z2003PENIDO, Carmen et al. Role of Monocyte Chemotactic Protein-1/CC Chemokine Ligand 2 on T Lymphocyte Trafficking during Inflammation Induced by Lipopolysaccharide or Mycobacterium bovis Bacille Calmette-Guérin. Journal of Immunology, v. 171, p. 6788-6794, 2003.0022-1767https://www.arca.fiocruz.br/handle/icict/4107310.4049/jimmunol.171.12.67881550-6606Acesso aberto em 03/05/2020 - https://www.jimmunol.org/content/171/12/6788Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Gammadelta T lymphocytes are involved in a great variety of inflammatory and infectious responses. However, the mechanisms by which gammadelta T lymphocytes migrate to inflamed sites are poorly understood. In this study we investigate the role of monocyte chemotactic protein (MCP)-1 in regulating gammadelta T cell migration after LPS or Mycobacterium bovis bacille Calmette-Guérin (BCG) challenge. LPS-induced gammadelta T cell influx was significantly inhibited by either pretreatment with dexamethasone or vaccinia virus Lister 35-kDa chemokine binding protein, vCKBP, a CC chemokine neutralizing protein, suggesting a role for CC chemokines in this phenomenon. LPS stimulation increased the expression of MCP-1 mRNA and protein at the inflammation site within 6 h. It is noteworthy that LPS was unable to increase MCP-1 production or gammadelta T cell recruitment in C3H/HeJ, indicative of the involvement of Toll-like receptor 4. Gammadelta T cells express MCP-1 receptor CCR2. Pretreatment with anti-MCP-1 mAb drastically inhibited LPS-induced in vivo gammadelta T cell mobilization. Indeed, MCP-1 knockout mice were unable to recruit gammadelta T cells to the pleural cavity after LPS stimulation, effect that could be restored by coadministration of MCP-1. In addition, BCG-induced gammadelta lymphocyte accumulation was significantly reduced in MCP-1 knockout mice when compared with wild-type mice. In conclusion, our results indicate that LPS-induced gammadelta T lymphocyte migration is dependent on Toll-like receptor 4 and sensitive to both dexamethasone and CC chemokine-binding protein inhibition. Moreover, by using MCP-1 neutralizing Abs and genetically deficient mice we show that LPS- and BCG-induced gammadelta T lymphocyte influx to the pleural cavity of mice is mainly orchestrated by the CC chemokine MCP-1.engAmerican Association of ImmunologistsMycobacterium bovisLipopolysaccharideBacille Calmette-GuérinQuimiocina da proteína quimiotática-1 de monócitos / CCLinfócitos TInflamaçãoMycobacterium bovisLipopolysaccharideBacille Calmette-GuérinChemotactic Protein-1/CC ChemokineInflammationT Lymphocyte TraffickingRole of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin
title Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin
spellingShingle Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin
Penido, Carmen
Mycobacterium bovis
Lipopolysaccharide
Bacille Calmette-Guérin
Quimiocina da proteína quimiotática-1 de monócitos / CC
Linfócitos T
Inflamação
Mycobacterium bovis
Lipopolysaccharide
Bacille Calmette-Guérin
Chemotactic Protein-1/CC Chemokine
Inflammation
T Lymphocyte Trafficking
title_short Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin
title_full Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin
title_fullStr Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin
title_full_unstemmed Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin
title_sort Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin
author Penido, Carmen
author_facet Penido, Carmen
Abreu, Adriana Vieira de
Bozza, Marcelo T.
Faria Neto, Hugo Caire C.
Bozza, Patrícia T.
author_role author
author2 Abreu, Adriana Vieira de
Bozza, Marcelo T.
Faria Neto, Hugo Caire C.
Bozza, Patrícia T.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Penido, Carmen
Abreu, Adriana Vieira de
Bozza, Marcelo T.
Faria Neto, Hugo Caire C.
Bozza, Patrícia T.
dc.subject.other.pt_BR.fl_str_mv Mycobacterium bovis
Lipopolysaccharide
Bacille Calmette-Guérin
Quimiocina da proteína quimiotática-1 de monócitos / CC
Linfócitos T
Inflamação
topic Mycobacterium bovis
Lipopolysaccharide
Bacille Calmette-Guérin
Quimiocina da proteína quimiotática-1 de monócitos / CC
Linfócitos T
Inflamação
Mycobacterium bovis
Lipopolysaccharide
Bacille Calmette-Guérin
Chemotactic Protein-1/CC Chemokine
Inflammation
T Lymphocyte Trafficking
dc.subject.en.pt_BR.fl_str_mv Mycobacterium bovis
Lipopolysaccharide
Bacille Calmette-Guérin
Chemotactic Protein-1/CC Chemokine
Inflammation
T Lymphocyte Trafficking
description Acesso aberto em 03/05/2020 - https://www.jimmunol.org/content/171/12/6788
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2020-05-03T18:42:02Z
dc.date.available.fl_str_mv 2020-05-03T18:42:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PENIDO, Carmen et al. Role of Monocyte Chemotactic Protein-1/CC Chemokine Ligand 2 on T Lymphocyte Trafficking during Inflammation Induced by Lipopolysaccharide or Mycobacterium bovis Bacille Calmette-Guérin. Journal of Immunology, v. 171, p. 6788-6794, 2003.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/41073
dc.identifier.issn.pt_BR.fl_str_mv 0022-1767
dc.identifier.doi.none.fl_str_mv 10.4049/jimmunol.171.12.6788
dc.identifier.eissn.none.fl_str_mv 1550-6606
identifier_str_mv PENIDO, Carmen et al. Role of Monocyte Chemotactic Protein-1/CC Chemokine Ligand 2 on T Lymphocyte Trafficking during Inflammation Induced by Lipopolysaccharide or Mycobacterium bovis Bacille Calmette-Guérin. Journal of Immunology, v. 171, p. 6788-6794, 2003.
0022-1767
10.4049/jimmunol.171.12.6788
1550-6606
url https://www.arca.fiocruz.br/handle/icict/41073
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Association of Immunologists
publisher.none.fl_str_mv American Association of Immunologists
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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