Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/41073 |
Resumo: | Acesso aberto em 03/05/2020 - https://www.jimmunol.org/content/171/12/6788 |
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Penido, CarmenAbreu, Adriana Vieira deBozza, Marcelo T.Faria Neto, Hugo Caire C.Bozza, Patrícia T.2020-05-03T18:42:02Z2020-05-03T18:42:02Z2003PENIDO, Carmen et al. Role of Monocyte Chemotactic Protein-1/CC Chemokine Ligand 2 on T Lymphocyte Trafficking during Inflammation Induced by Lipopolysaccharide or Mycobacterium bovis Bacille Calmette-Guérin. Journal of Immunology, v. 171, p. 6788-6794, 2003.0022-1767https://www.arca.fiocruz.br/handle/icict/4107310.4049/jimmunol.171.12.67881550-6606Acesso aberto em 03/05/2020 - https://www.jimmunol.org/content/171/12/6788Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Gammadelta T lymphocytes are involved in a great variety of inflammatory and infectious responses. However, the mechanisms by which gammadelta T lymphocytes migrate to inflamed sites are poorly understood. In this study we investigate the role of monocyte chemotactic protein (MCP)-1 in regulating gammadelta T cell migration after LPS or Mycobacterium bovis bacille Calmette-Guérin (BCG) challenge. LPS-induced gammadelta T cell influx was significantly inhibited by either pretreatment with dexamethasone or vaccinia virus Lister 35-kDa chemokine binding protein, vCKBP, a CC chemokine neutralizing protein, suggesting a role for CC chemokines in this phenomenon. LPS stimulation increased the expression of MCP-1 mRNA and protein at the inflammation site within 6 h. It is noteworthy that LPS was unable to increase MCP-1 production or gammadelta T cell recruitment in C3H/HeJ, indicative of the involvement of Toll-like receptor 4. Gammadelta T cells express MCP-1 receptor CCR2. Pretreatment with anti-MCP-1 mAb drastically inhibited LPS-induced in vivo gammadelta T cell mobilization. Indeed, MCP-1 knockout mice were unable to recruit gammadelta T cells to the pleural cavity after LPS stimulation, effect that could be restored by coadministration of MCP-1. In addition, BCG-induced gammadelta lymphocyte accumulation was significantly reduced in MCP-1 knockout mice when compared with wild-type mice. In conclusion, our results indicate that LPS-induced gammadelta T lymphocyte migration is dependent on Toll-like receptor 4 and sensitive to both dexamethasone and CC chemokine-binding protein inhibition. Moreover, by using MCP-1 neutralizing Abs and genetically deficient mice we show that LPS- and BCG-induced gammadelta T lymphocyte influx to the pleural cavity of mice is mainly orchestrated by the CC chemokine MCP-1.engAmerican Association of ImmunologistsMycobacterium bovisLipopolysaccharideBacille Calmette-GuérinQuimiocina da proteína quimiotática-1 de monócitos / CCLinfócitos TInflamaçãoMycobacterium bovisLipopolysaccharideBacille Calmette-GuérinChemotactic Protein-1/CC ChemokineInflammationT Lymphocyte TraffickingRole of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin |
title |
Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin |
spellingShingle |
Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin Penido, Carmen Mycobacterium bovis Lipopolysaccharide Bacille Calmette-Guérin Quimiocina da proteína quimiotática-1 de monócitos / CC Linfócitos T Inflamação Mycobacterium bovis Lipopolysaccharide Bacille Calmette-Guérin Chemotactic Protein-1/CC Chemokine Inflammation T Lymphocyte Trafficking |
title_short |
Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin |
title_full |
Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin |
title_fullStr |
Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin |
title_full_unstemmed |
Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin |
title_sort |
Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin |
author |
Penido, Carmen |
author_facet |
Penido, Carmen Abreu, Adriana Vieira de Bozza, Marcelo T. Faria Neto, Hugo Caire C. Bozza, Patrícia T. |
author_role |
author |
author2 |
Abreu, Adriana Vieira de Bozza, Marcelo T. Faria Neto, Hugo Caire C. Bozza, Patrícia T. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Penido, Carmen Abreu, Adriana Vieira de Bozza, Marcelo T. Faria Neto, Hugo Caire C. Bozza, Patrícia T. |
dc.subject.other.pt_BR.fl_str_mv |
Mycobacterium bovis Lipopolysaccharide Bacille Calmette-Guérin Quimiocina da proteína quimiotática-1 de monócitos / CC Linfócitos T Inflamação |
topic |
Mycobacterium bovis Lipopolysaccharide Bacille Calmette-Guérin Quimiocina da proteína quimiotática-1 de monócitos / CC Linfócitos T Inflamação Mycobacterium bovis Lipopolysaccharide Bacille Calmette-Guérin Chemotactic Protein-1/CC Chemokine Inflammation T Lymphocyte Trafficking |
dc.subject.en.pt_BR.fl_str_mv |
Mycobacterium bovis Lipopolysaccharide Bacille Calmette-Guérin Chemotactic Protein-1/CC Chemokine Inflammation T Lymphocyte Trafficking |
description |
Acesso aberto em 03/05/2020 - https://www.jimmunol.org/content/171/12/6788 |
publishDate |
2003 |
dc.date.issued.fl_str_mv |
2003 |
dc.date.accessioned.fl_str_mv |
2020-05-03T18:42:02Z |
dc.date.available.fl_str_mv |
2020-05-03T18:42:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PENIDO, Carmen et al. Role of Monocyte Chemotactic Protein-1/CC Chemokine Ligand 2 on T Lymphocyte Trafficking during Inflammation Induced by Lipopolysaccharide or Mycobacterium bovis Bacille Calmette-Guérin. Journal of Immunology, v. 171, p. 6788-6794, 2003. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/41073 |
dc.identifier.issn.pt_BR.fl_str_mv |
0022-1767 |
dc.identifier.doi.none.fl_str_mv |
10.4049/jimmunol.171.12.6788 |
dc.identifier.eissn.none.fl_str_mv |
1550-6606 |
identifier_str_mv |
PENIDO, Carmen et al. Role of Monocyte Chemotactic Protein-1/CC Chemokine Ligand 2 on T Lymphocyte Trafficking during Inflammation Induced by Lipopolysaccharide or Mycobacterium bovis Bacille Calmette-Guérin. Journal of Immunology, v. 171, p. 6788-6794, 2003. 0022-1767 10.4049/jimmunol.171.12.6788 1550-6606 |
url |
https://www.arca.fiocruz.br/handle/icict/41073 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
American Association of Immunologists |
publisher.none.fl_str_mv |
American Association of Immunologists |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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