The Prenatal Origin of Childhood Leukemia: Potential Applications for Epidemiology and Newborn Screening

Detalhes bibliográficos
Autor(a) principal: Marcotte, Erin L.
Data de Publicação: 2021
Outros Autores: Spector, Logan G., Mendes-de-Almeida, Daniela P., Nelson, Heather H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50528
Resumo: University of Minnesota. Department of Pediatrics. Division of Epidemiology & Clinical Research. Minneapolis, MN, USA / University of Minnesota. Masonic Cancer Center. Minneapolis, MN, USA.
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spelling Marcotte, Erin L.Spector, Logan G.Mendes-de-Almeida, Daniela P.Nelson, Heather H.2021-12-27T22:29:19Z2021-12-27T22:29:19Z2021MARCOTTE, Erin L. et al. The Prenatal Origin of Childhood Leukemia: Potential Applications for Epidemiology and Newborn Screening. Frontiers in Pediatrics, v. 9, p. 1-15, 2021.2296-2360https://www.arca.fiocruz.br/handle/icict/5052810.3389/fped.2021.639479engFrontiers MediaThe Prenatal Origin of Childhood Leukemia: Potential Applications for Epidemiology and Newborn Screeninginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Minnesota. Department of Pediatrics. Division of Epidemiology & Clinical Research. Minneapolis, MN, USA / University of Minnesota. Masonic Cancer Center. Minneapolis, MN, USA.University of Minnesota. Department of Pediatrics. Division of Epidemiology & Clinical Research. Minneapolis, MN, USA / University of Minnesota. Masonic Cancer Center. Minneapolis, MN, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Departamento de Hematologia. Rio de Janeiro, RJ, Brasil / University of Minnesota. Department of Pediatrics. Division of Epidemiology & Clinical Research. Minneapolis, MN, USA / Instituto Nacional de Câncer. Centro de Pesquisa. Divisão de Carcinogênese Molecular. Rio de Janeiro, RJ, Brasil.University of Minnesota. Masonic Cancer Center. Minneapolis, MN, USA / University of Minnesota. School of Public Health. Division of Epidemiology and Community Health. Minneapolis, MN, USA.Childhood leukemias are heterogeneous diseases with widely differing incident rates worldwide. As circulating tumors, childhood acute leukemias are uniquely accessible, and their natural history has been described in greater detail than for solid tumors. For several decades, it has been apparent that most cases of childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) initiate in utero. Circumstantial evidence in support of this contention includes the young age of onset and high rate of concordance among identical twins. "Backtracking" of leukemic somatic mutations, particularly gene translocations, to cord blood and dried blood spots collected during the perinatal period has provided molecular proof of prenatal leukemogenesis. Detection of a patient's leukemia translocation in easily accessible birth samples, such as dried blood spots, is straightforward with the knowledge of their idiosyncratic breakpoints. However, to translate these findings into population-based screening and leukemia prevention requires novel methods able to detect translocations at all possible breakpoints when present in a low frequency of cells. Several studies have attempted to screen for leukemic translocations, mainly the common ETV6-RUNX1 translocation, in cord blood samples from healthy children. Most studies have reported finding translocations in healthy children, but estimates of prevalence have varied widely and greatly exceed the incidence of leukemia, leading to concerns that technical artifact or contamination produced an artificially inflated estimate of translocation prevalence at birth. New generation techniques that capture the presence of these translocations at birth have the potential to vastly increase our understanding of the epidemiology of acute leukemias. For instance, if leukemic translocations are present at birth in a far higher proportion of children than eventually develop acute leukemia, what are the exposures and somatic molecular events that lead to disease? And could children with translocations present at birth be targeted for prevention of disease? These questions must be answered before large-scale newborn screening for leukemia can occur as a public health initiative. Here, we review the literature regarding backtracking of acute leukemias and the prevalence of leukemic translocations at birth. We further suggest an agenda for epidemiologic research using new tools for population screening of leukemic translocations.Childhood leukemiaEpidemiologyLeukemiaNewbornsScreeningTranslocationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/50528/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALThe prenatal_Daniela_Almeida_etal_INI_2021.pdfThe prenatal_Daniela_Almeida_etal_INI_2021.pdfapplication/pdf1656372https://www.arca.fiocruz.br/bitstream/icict/50528/2/The%20prenatal_Daniela_Almeida_etal_INI_2021.pdfff4a45fc2a177cb2819e9febf54c4074MD52icict/505282023-11-13 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dc.title.pt_BR.fl_str_mv The Prenatal Origin of Childhood Leukemia: Potential Applications for Epidemiology and Newborn Screening
title The Prenatal Origin of Childhood Leukemia: Potential Applications for Epidemiology and Newborn Screening
spellingShingle The Prenatal Origin of Childhood Leukemia: Potential Applications for Epidemiology and Newborn Screening
Marcotte, Erin L.
Childhood leukemia
Epidemiology
Leukemia
Newborns
Screening
Translocation
title_short The Prenatal Origin of Childhood Leukemia: Potential Applications for Epidemiology and Newborn Screening
title_full The Prenatal Origin of Childhood Leukemia: Potential Applications for Epidemiology and Newborn Screening
title_fullStr The Prenatal Origin of Childhood Leukemia: Potential Applications for Epidemiology and Newborn Screening
title_full_unstemmed The Prenatal Origin of Childhood Leukemia: Potential Applications for Epidemiology and Newborn Screening
title_sort The Prenatal Origin of Childhood Leukemia: Potential Applications for Epidemiology and Newborn Screening
author Marcotte, Erin L.
author_facet Marcotte, Erin L.
Spector, Logan G.
Mendes-de-Almeida, Daniela P.
Nelson, Heather H.
author_role author
author2 Spector, Logan G.
Mendes-de-Almeida, Daniela P.
Nelson, Heather H.
author2_role author
author
author
dc.contributor.author.fl_str_mv Marcotte, Erin L.
Spector, Logan G.
Mendes-de-Almeida, Daniela P.
Nelson, Heather H.
dc.subject.en.pt_BR.fl_str_mv Childhood leukemia
Epidemiology
Leukemia
Newborns
Screening
Translocation
topic Childhood leukemia
Epidemiology
Leukemia
Newborns
Screening
Translocation
description University of Minnesota. Department of Pediatrics. Division of Epidemiology & Clinical Research. Minneapolis, MN, USA / University of Minnesota. Masonic Cancer Center. Minneapolis, MN, USA.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-27T22:29:19Z
dc.date.available.fl_str_mv 2021-12-27T22:29:19Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MARCOTTE, Erin L. et al. The Prenatal Origin of Childhood Leukemia: Potential Applications for Epidemiology and Newborn Screening. Frontiers in Pediatrics, v. 9, p. 1-15, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50528
dc.identifier.issn.pt_BR.fl_str_mv 2296-2360
dc.identifier.doi.none.fl_str_mv 10.3389/fped.2021.639479
identifier_str_mv MARCOTTE, Erin L. et al. The Prenatal Origin of Childhood Leukemia: Potential Applications for Epidemiology and Newborn Screening. Frontiers in Pediatrics, v. 9, p. 1-15, 2021.
2296-2360
10.3389/fped.2021.639479
url https://www.arca.fiocruz.br/handle/icict/50528
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50528/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50528/2/The%20prenatal_Daniela_Almeida_etal_INI_2021.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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