Clinical Profile and Risk Factors for Severe COVID-19 in Hospitalized Patients from Rio de Janeiro, Brazil: Comparison between the First and Second Pandemic Waves
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/57667 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento tecnológico em Virologia. Rio de Janeiro, RJ, Brasil. |
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Amado, Luciane AlmeidaCoelho, Wagner Luis da Costa Nunes PimentelAlves, Arthur Daniel RochaCarneiro, Vanessa Cristine de SouzaMoreira, Otacilio da CruzPaula, Vanessa Salete deLemos, Andreza SalvioDuarte, Larissa AraujoGutman, Elisa GouveaDantas, Fabricia Lima FontesGonçalves, João Paulo da CostaRamos, Carlos Henrique FerreiraRamos Filho, Carlos Henrique FerreiraCavalcanti, Marta GuimarãesAmaro, Marisa PimentelKader, Rafael LopesMedronho, Roberto de AndradeSarmento, Dmitry José de SantanaAlves Leon, Soniza Vieira2023-04-03T18:38:36Z2023-04-03T18:38:36Z2023AMADO, Luciane Almeida et al. Clinical Profile and Risk Factors for Severe COVID-19 in Hospitalized Patients from Rio de Janeiro, Brazil: Comparison between the First and Second Pandemic Waves. Journal of Clinical Medicine, v. 12, 2568, p. 1 - 19, Mar. 2023.2077-0383https://www.arca.fiocruz.br/handle/icict/5766710.3390/jcm12072568engMDPICOVID-19Fatores de RiscoEpidemiologiaOndas epidêmicasCOVID-19Risk FactorsEpidemiologyEpidemic wavesClinical Profile and Risk Factors for Severe COVID-19 in Hospitalized Patients from Rio de Janeiro, Brazil: Comparison between the First and Second Pandemic Wavesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento tecnológico em Virologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endemicas. Plataforma de PCR em tempo real RPT09A. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Instituto Biomédico. Laboratório de Neurociências Translacionais. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro, Escola de Medicina. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Instituto Biomédico. Laboratório de Neurociências Translacionais. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Escola de Medicina. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. UNIRIO - Instituto Biomédico. Laboratório de Neurociências Translacionais. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Instituto de Biologia Roberto Alcântara Gomes Departamento de Farmacologia e Psicobiologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. UNIRIO - Instituto Biomédico. Laboratório de Neurociências Translacionais. Rio de Janeiro, RJ, BrasilUniversidade Federal do Estado do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Unidade de Tratamento Intensivo. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Unidade de Tratamento Intensivo. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Serviço de Epidemiologia e Avaliação. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Escola de Medicina. Programa de Pós-Graduação em Doenças Infecciosas e Parasitárias. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Escola de Medicina. Programa de Pós-Graduação em Doenças Infecciosas e Parasitárias. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro, Escola de Medicina. Rio de Janeiro, RJ, Brasil.Universidade do Estado da Paraíba. Escola de Odontologia. Departamento de Diagnóstico Oral. Araruna, PB, Brasil.Universidade Federal do Estado do Rio de Janeiro. Instituto Biomédico. Laboratório de Neurociências Translacionais. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro, Escola de Medicina. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Departamento de Neurologia. Centro de Referência e Investigação em Esclerose Múltipla e Outros Sistemas Nervosos Centrais. Doenças Inflamatórias Desmielinizantes Idiopáticas do Sistema. Rio de Janeiro, RJ, Brasil.Since COVID-19 was declared a pandemic, Brazil has become one of the countries most affected by this disease. A year into the pandemic, a second wave of COVID-19 emerged, with a rapid spread of a new SARS-CoV-2 lineage of concern. Several vaccines have been granted emergency-use authorization, leading to a decrease inmortality and severe cases inmany countries. However, the emergence of SARSCoV- 2 variants raises the alert for potential newwaves of transmission and an increase in pathogenicity. We compared the demographic and clinical data of critically ill patients infected with COVID-19 hospitalized in Rio de Janeiro during the first and second waves between July 2020 and October 2021. In total, 106 participants were included in this study; among them, 88% had at least one comorbidity, and 37% developed severe disease. Disease severity was associated with older age, pre-existing neurological comorbidities, higher viral load, and dyspnea. Laboratory biomarkers related to white blood cells, coagulation, cellular injury, inflammation, renal, and liver injuries were significantly associated with severe COVID-19. During the second wave of the pandemic, the necessity of invasive respiratory support was higher, andmore individuals with COVID-19 developed acute hepatitis, suggesting that the progression of the second wave resulted in an increase in severe cases. These results can contribute to understanding the behavior of the COVID-19 pandemic in Brazil and may be helpful in predicting disease severity, which is a pivotal for guiding clinical care, improving patient outcomes, and defining public policies.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57667/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALOctacilioMoreira_Vanessa de Paul_etal_IOC_2023.pdfOctacilioMoreira_Vanessa de Paul_etal_IOC_2023.pdfapplication/pdf370429https://www.arca.fiocruz.br/bitstream/icict/57667/2/OctacilioMoreira_Vanessa%20de%20Paul_etal_IOC_2023.pdf76380252808a2abf89321bfedbde0b00MD52icict/576672023-09-14 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dc.title.en_US.fl_str_mv |
Clinical Profile and Risk Factors for Severe COVID-19 in Hospitalized Patients from Rio de Janeiro, Brazil: Comparison between the First and Second Pandemic Waves |
title |
Clinical Profile and Risk Factors for Severe COVID-19 in Hospitalized Patients from Rio de Janeiro, Brazil: Comparison between the First and Second Pandemic Waves |
spellingShingle |
Clinical Profile and Risk Factors for Severe COVID-19 in Hospitalized Patients from Rio de Janeiro, Brazil: Comparison between the First and Second Pandemic Waves Amado, Luciane Almeida COVID-19 Fatores de Risco Epidemiologia Ondas epidêmicas COVID-19 Risk Factors Epidemiology Epidemic waves |
title_short |
Clinical Profile and Risk Factors for Severe COVID-19 in Hospitalized Patients from Rio de Janeiro, Brazil: Comparison between the First and Second Pandemic Waves |
title_full |
Clinical Profile and Risk Factors for Severe COVID-19 in Hospitalized Patients from Rio de Janeiro, Brazil: Comparison between the First and Second Pandemic Waves |
title_fullStr |
Clinical Profile and Risk Factors for Severe COVID-19 in Hospitalized Patients from Rio de Janeiro, Brazil: Comparison between the First and Second Pandemic Waves |
title_full_unstemmed |
Clinical Profile and Risk Factors for Severe COVID-19 in Hospitalized Patients from Rio de Janeiro, Brazil: Comparison between the First and Second Pandemic Waves |
title_sort |
Clinical Profile and Risk Factors for Severe COVID-19 in Hospitalized Patients from Rio de Janeiro, Brazil: Comparison between the First and Second Pandemic Waves |
author |
Amado, Luciane Almeida |
author_facet |
Amado, Luciane Almeida Coelho, Wagner Luis da Costa Nunes Pimentel Alves, Arthur Daniel Rocha Carneiro, Vanessa Cristine de Souza Moreira, Otacilio da Cruz Paula, Vanessa Salete de Lemos, Andreza Salvio Duarte, Larissa Araujo Gutman, Elisa Gouvea Dantas, Fabricia Lima Fontes Gonçalves, João Paulo da Costa Ramos, Carlos Henrique Ferreira Ramos Filho, Carlos Henrique Ferreira Cavalcanti, Marta Guimarães Amaro, Marisa Pimentel Kader, Rafael Lopes Medronho, Roberto de Andrade Sarmento, Dmitry José de Santana Alves Leon, Soniza Vieira |
author_role |
author |
author2 |
Coelho, Wagner Luis da Costa Nunes Pimentel Alves, Arthur Daniel Rocha Carneiro, Vanessa Cristine de Souza Moreira, Otacilio da Cruz Paula, Vanessa Salete de Lemos, Andreza Salvio Duarte, Larissa Araujo Gutman, Elisa Gouvea Dantas, Fabricia Lima Fontes Gonçalves, João Paulo da Costa Ramos, Carlos Henrique Ferreira Ramos Filho, Carlos Henrique Ferreira Cavalcanti, Marta Guimarães Amaro, Marisa Pimentel Kader, Rafael Lopes Medronho, Roberto de Andrade Sarmento, Dmitry José de Santana Alves Leon, Soniza Vieira |
author2_role |
author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Amado, Luciane Almeida Coelho, Wagner Luis da Costa Nunes Pimentel Alves, Arthur Daniel Rocha Carneiro, Vanessa Cristine de Souza Moreira, Otacilio da Cruz Paula, Vanessa Salete de Lemos, Andreza Salvio Duarte, Larissa Araujo Gutman, Elisa Gouvea Dantas, Fabricia Lima Fontes Gonçalves, João Paulo da Costa Ramos, Carlos Henrique Ferreira Ramos Filho, Carlos Henrique Ferreira Cavalcanti, Marta Guimarães Amaro, Marisa Pimentel Kader, Rafael Lopes Medronho, Roberto de Andrade Sarmento, Dmitry José de Santana Alves Leon, Soniza Vieira |
dc.subject.other.en_US.fl_str_mv |
COVID-19 Fatores de Risco Epidemiologia Ondas epidêmicas |
topic |
COVID-19 Fatores de Risco Epidemiologia Ondas epidêmicas COVID-19 Risk Factors Epidemiology Epidemic waves |
dc.subject.en.en_US.fl_str_mv |
COVID-19 Risk Factors Epidemiology Epidemic waves |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento tecnológico em Virologia. Rio de Janeiro, RJ, Brasil. |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-04-03T18:38:36Z |
dc.date.available.fl_str_mv |
2023-04-03T18:38:36Z |
dc.date.issued.fl_str_mv |
2023 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
AMADO, Luciane Almeida et al. Clinical Profile and Risk Factors for Severe COVID-19 in Hospitalized Patients from Rio de Janeiro, Brazil: Comparison between the First and Second Pandemic Waves. Journal of Clinical Medicine, v. 12, 2568, p. 1 - 19, Mar. 2023. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/57667 |
dc.identifier.issn.en_US.fl_str_mv |
2077-0383 |
dc.identifier.doi.none.fl_str_mv |
10.3390/jcm12072568 |
identifier_str_mv |
AMADO, Luciane Almeida et al. Clinical Profile and Risk Factors for Severe COVID-19 in Hospitalized Patients from Rio de Janeiro, Brazil: Comparison between the First and Second Pandemic Waves. Journal of Clinical Medicine, v. 12, 2568, p. 1 - 19, Mar. 2023. 2077-0383 10.3390/jcm12072568 |
url |
https://www.arca.fiocruz.br/handle/icict/57667 |
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eng |
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eng |
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dc.publisher.none.fl_str_mv |
MDPI |
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MDPI |
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