Recombinant antigens used as diagnostic tools for lymphatic filariasis

Detalhes bibliográficos
Autor(a) principal: Pastor, André Filipe
Data de Publicação: 2021
Outros Autores: Silva, Maressa Rhuama, dos Santos, Wagner José Tenório, Rego, Tamisa, Brandão, Eduardo, de-Melo-Neto, Osvaldo Pompilio, Rocha, Abraham
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58205
Resumo: Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. Instituto Federal de Educação, Ciência e Tecnologia do Sertão Pernambucano. Floresta, PE, Brazil. Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Serviço de Referência Nacional em Filarioses. Recife, PE, Brazil. Secretaria de Saúde do Estado de Pernambuco. Laboratório do Hospital Otávio de Freitas. Recife, PE, Brazil.
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spelling Pastor, André FilipeSilva, Maressa Rhuamados Santos, Wagner José TenórioRego, TamisaBrandão, Eduardode-Melo-Neto, Osvaldo PompilioRocha, Abraham2023-05-08T16:19:59Z2023-05-08T16:19:59Z2021PASTOR, André Filipe et al. Recombinant antigens used as diagnostic tools for lymphatic filariasis. Parasites & Vectors, [S.l.], v. 14, n. 1, p. 1-14, 15 set. 2021.1756-3305https://www.arca.fiocruz.br/handle/icict/5820510.1186/s13071-021-04980-31756-3305porAnimalsAntibodies, HelminthBrugiaElephantiasis, FilarialHelminth ProteinsHumansSensitivity and SpecificityWuchereria bancroftiAntibodiesELISASensitivitySpecificityWuchereria bancroftiImmunoglobulin GRecombinant antigens used as diagnostic tools for lymphatic filariasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. Instituto Federal de Educação, Ciência e Tecnologia do Sertão Pernambucano. Floresta, PE, Brazil. Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Serviço de Referência Nacional em Filarioses. Recife, PE, Brazil. Secretaria de Saúde do Estado de Pernambuco. Laboratório do Hospital Otávio de Freitas. Recife, PE, Brazil.Lymphatic filariasis (LF) is a parasitic disease caused by the worms Wuchereria bancrofti, Brugia malayi, or Brugia timori. It is a tropical and subtropical illness that affects approximately 67 million people worldwide and that still requires better diagnostic tools to prevent its spread and enhance the effectiveness of control procedures. Traditional parasitological tests and diagnostic methods based on whole protein extracts from different worms are known for problems related to sample time collection, sensitivity, and specificity. More recently, new diagnostic tools based on immunological methods using recombinant antigens have been developed. The current review describes the several recombinant antigens used as tools for lymphatic filariasis diagnosis in antigen and antibody capture assays, highlighting their advantages and limitations as well as the main commercial tests developed based on them. The literature chronology is from 1991 to 2021. First, it describes the historical background related to the identification of relevant antigens and the generation of the recombinant polypeptides used for the LF diagnosis, also detailing features specific to each antigen. The subsequent section then discusses the use of those proteins to develop antigen and antibody capture tests to detect LF. So far, studies focusing on antibody capture assays are based on 13 different antigens with at least six commercially available tests, with five proteins further used for the development of antigen capture tests. Five antigens explored in this paper belong to the SXP/RAL-2 family (BmSXP, Bm14, WbSXP-1, Wb14, WbL), and the others are BmShp-1, Bm33, BmR1, BmVAH, WbVAH, BmALT-1, BmALT-2, and Wb123. It is expected that advances in research with these antigens will allow further development of tests combining both sensitivity and specificity with low costs, assisting the Global Program to Eliminate Lymphatic Filariasis (GPELF).info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83088https://www.arca.fiocruz.br/bitstream/icict/58205/1/license.txt7b043faf2a6ad46e5344ca8d54801d8cMD51ORIGINALRecombinant antigens used as diagnostic tools for lymphatic filariasis.pdfRecombinant antigens used as diagnostic tools for lymphatic filariasis.pdfapplication/pdf1162899https://www.arca.fiocruz.br/bitstream/icict/58205/2/Recombinant%20antigens%20used%20as%20diagnostic%20tools%20for%20lymphatic%20filariasis.pdf2ba4862547f5c9fd72157fcce1c095d8MD52icict/582052023-05-30 11:12:40.899oai:www.arca.fiocruz.br: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Repositório 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dc.title.en_US.fl_str_mv Recombinant antigens used as diagnostic tools for lymphatic filariasis
title Recombinant antigens used as diagnostic tools for lymphatic filariasis
spellingShingle Recombinant antigens used as diagnostic tools for lymphatic filariasis
Pastor, André Filipe
Animals
Antibodies, Helminth
Brugia
Elephantiasis, Filarial
Helminth Proteins
Humans
Sensitivity and Specificity
Wuchereria bancrofti
Antibodies
ELISA
Sensitivity
Specificity
Wuchereria bancrofti
Immunoglobulin G
title_short Recombinant antigens used as diagnostic tools for lymphatic filariasis
title_full Recombinant antigens used as diagnostic tools for lymphatic filariasis
title_fullStr Recombinant antigens used as diagnostic tools for lymphatic filariasis
title_full_unstemmed Recombinant antigens used as diagnostic tools for lymphatic filariasis
title_sort Recombinant antigens used as diagnostic tools for lymphatic filariasis
author Pastor, André Filipe
author_facet Pastor, André Filipe
Silva, Maressa Rhuama
dos Santos, Wagner José Tenório
Rego, Tamisa
Brandão, Eduardo
de-Melo-Neto, Osvaldo Pompilio
Rocha, Abraham
author_role author
author2 Silva, Maressa Rhuama
dos Santos, Wagner José Tenório
Rego, Tamisa
Brandão, Eduardo
de-Melo-Neto, Osvaldo Pompilio
Rocha, Abraham
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pastor, André Filipe
Silva, Maressa Rhuama
dos Santos, Wagner José Tenório
Rego, Tamisa
Brandão, Eduardo
de-Melo-Neto, Osvaldo Pompilio
Rocha, Abraham
dc.subject.mesh.en_US.fl_str_mv Animals
Antibodies, Helminth
Brugia
Elephantiasis, Filarial
Helminth Proteins
Humans
Sensitivity and Specificity
Wuchereria bancrofti
topic Animals
Antibodies, Helminth
Brugia
Elephantiasis, Filarial
Helminth Proteins
Humans
Sensitivity and Specificity
Wuchereria bancrofti
Antibodies
ELISA
Sensitivity
Specificity
Wuchereria bancrofti
Immunoglobulin G
dc.subject.en.en_US.fl_str_mv Antibodies
ELISA
Sensitivity
Specificity
Wuchereria bancrofti
Immunoglobulin G
description Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. Instituto Federal de Educação, Ciência e Tecnologia do Sertão Pernambucano. Floresta, PE, Brazil. Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Serviço de Referência Nacional em Filarioses. Recife, PE, Brazil. Secretaria de Saúde do Estado de Pernambuco. Laboratório do Hospital Otávio de Freitas. Recife, PE, Brazil.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2023-05-08T16:19:59Z
dc.date.available.fl_str_mv 2023-05-08T16:19:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PASTOR, André Filipe et al. Recombinant antigens used as diagnostic tools for lymphatic filariasis. Parasites & Vectors, [S.l.], v. 14, n. 1, p. 1-14, 15 set. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58205
dc.identifier.issn.en_US.fl_str_mv 1756-3305
dc.identifier.doi.none.fl_str_mv 10.1186/s13071-021-04980-3
dc.identifier.eissn.none.fl_str_mv 1756-3305
identifier_str_mv PASTOR, André Filipe et al. Recombinant antigens used as diagnostic tools for lymphatic filariasis. Parasites & Vectors, [S.l.], v. 14, n. 1, p. 1-14, 15 set. 2021.
1756-3305
10.1186/s13071-021-04980-3
url https://www.arca.fiocruz.br/handle/icict/58205
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/58205/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/58205/2/Recombinant%20antigens%20used%20as%20diagnostic%20tools%20for%20lymphatic%20filariasis.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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