Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors.
Autor(a) principal: | |
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Data de Publicação: | 2001 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8148 |
Resumo: | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Imunologia. Salvador, BA, Brasil |
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Carvalho Filho, Edgar MarcelinoBacellar, Maria Olívia Amado RamosPorto, Maria Aurélia da FonsecaBraga, SilvaneCastro Filho, Bernardo GalvãoNeva, Franklin A2014-08-07T13:02:14Z2014-08-07T13:02:14Z2001CARVALHO FILHO, E. M. et al. Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors. Journal of Acquired Immune Deficiency Syndromes, v. 27, n. 1, p. 1-6, 2001.1525-4135https://www.arca.fiocruz.br/handle/icict/8148engLippincott Williams & WilkinsCytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Imunologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilNational Institute of Allergy and Infectious Diseases. National Institutes of Health. Laboratory of Parasitic Diseases. Bethesda, Maryland, USAThe modulation of the immune response has been used as therapy for clinical disorders associated with human T-lymphotropic virus type 1 (HTLV-1) infection. In this study, the cytokine profile was evaluated in 26 asymptomatic HTLV-1 blood donors. Additionally, both the cell responsible for producing interferon-gamma (IFN-gamma) and the role of exogenous interleukin (IL)-10 in downregulating IFN-gamma production were studied. Cytokine levels were determined in supernatants of unstimulated lymphocyte cultures by enzyme-linked immunosorbent assay. The levels of IFN-gamma, tumor necrosis factor-alpha, IL-5, and IL-10 were higher in supernatants of the lymphocyte cultures taken from HTLV-1-infected donors than in those taken from healthy subjects. Although depletion of CD8+ T cells and natural killer cells did not affect IFN-gamma production, depletion of CD4+ T cells significantly decreased IFN-gamma production. Furthermore, at a concentration of 2 ng/ml, IL-10 had only a minimum effect on IFN-gamma production, although at high concentrations (100 ng/ml), IL-10 decreased IFN-gamma production by 50% in HTLV-1-infected individuals. These data indicate that both T helper 1 and T helper 2 cytokines are elevated in HTLV-1 infection and that IL-10 in high concentrations modulates IFN-gamma production in these patients.Cellular immunity in HTLV-1Citokines in HTLV-1HTLV-1Immune response in HTLV-1Immunomodulation in HTLV-1Doadores de SangueCitocinas/biossínteseInfecções por HTLV-I/imunologiaVírus 1 Linfotrópico T Humano/imunologiaAdultoLinfócitos T CD4-Positivos/imunologiaFemininoAnticorpos Anti-HTLV-I/sangueHumanosInterferon gama/biossínteseCélulas Matadoras Naturais/imunologiaMasculinoMeia-Idadeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCarvalho EM Cytokine Profile....pdfCarvalho EM Cytokine Profile....pdfapplication/pdf4020404https://www.arca.fiocruz.br/bitstream/icict/8148/1/Carvalho%20EM%20Cytokine%20Profile....pdf7c293e1e23c5998c1a26e3bf86849c6fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8148/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTCarvalho EM Cytokine Profile....pdf.txtCarvalho EM Cytokine Profile....pdf.txtExtracted texttext/plain6https://www.arca.fiocruz.br/bitstream/icict/8148/3/Carvalho%20EM%20Cytokine%20Profile....pdf.txt6d93d3216dc4a7f5df47d4876fbec4d3MD53icict/81482023-03-15 14:33:11.176oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:11Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors. |
title |
Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors. |
spellingShingle |
Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors. Carvalho Filho, Edgar Marcelino Cellular immunity in HTLV-1 Citokines in HTLV-1 HTLV-1 Immune response in HTLV-1 Immunomodulation in HTLV-1 Doadores de Sangue Citocinas/biossíntese Infecções por HTLV-I/imunologia Vírus 1 Linfotrópico T Humano/imunologia Adulto Linfócitos T CD4-Positivos/imunologia Feminino Anticorpos Anti-HTLV-I/sangue Humanos Interferon gama/biossíntese Células Matadoras Naturais/imunologia Masculino Meia-Idade |
title_short |
Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors. |
title_full |
Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors. |
title_fullStr |
Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors. |
title_full_unstemmed |
Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors. |
title_sort |
Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors. |
author |
Carvalho Filho, Edgar Marcelino |
author_facet |
Carvalho Filho, Edgar Marcelino Bacellar, Maria Olívia Amado Ramos Porto, Maria Aurélia da Fonseca Braga, Silvane Castro Filho, Bernardo Galvão Neva, Franklin A |
author_role |
author |
author2 |
Bacellar, Maria Olívia Amado Ramos Porto, Maria Aurélia da Fonseca Braga, Silvane Castro Filho, Bernardo Galvão Neva, Franklin A |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Carvalho Filho, Edgar Marcelino Bacellar, Maria Olívia Amado Ramos Porto, Maria Aurélia da Fonseca Braga, Silvane Castro Filho, Bernardo Galvão Neva, Franklin A |
dc.subject.en.pt_BR.fl_str_mv |
Cellular immunity in HTLV-1 Citokines in HTLV-1 HTLV-1 Immune response in HTLV-1 Immunomodulation in HTLV-1 |
topic |
Cellular immunity in HTLV-1 Citokines in HTLV-1 HTLV-1 Immune response in HTLV-1 Immunomodulation in HTLV-1 Doadores de Sangue Citocinas/biossíntese Infecções por HTLV-I/imunologia Vírus 1 Linfotrópico T Humano/imunologia Adulto Linfócitos T CD4-Positivos/imunologia Feminino Anticorpos Anti-HTLV-I/sangue Humanos Interferon gama/biossíntese Células Matadoras Naturais/imunologia Masculino Meia-Idade |
dc.subject.decs.pt_BR.fl_str_mv |
Doadores de Sangue Citocinas/biossíntese Infecções por HTLV-I/imunologia Vírus 1 Linfotrópico T Humano/imunologia Adulto Linfócitos T CD4-Positivos/imunologia Feminino Anticorpos Anti-HTLV-I/sangue Humanos Interferon gama/biossíntese Células Matadoras Naturais/imunologia Masculino Meia-Idade |
description |
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Imunologia. Salvador, BA, Brasil |
publishDate |
2001 |
dc.date.issued.fl_str_mv |
2001 |
dc.date.accessioned.fl_str_mv |
2014-08-07T13:02:14Z |
dc.date.available.fl_str_mv |
2014-08-07T13:02:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CARVALHO FILHO, E. M. et al. Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors. Journal of Acquired Immune Deficiency Syndromes, v. 27, n. 1, p. 1-6, 2001. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/8148 |
dc.identifier.issn.none.fl_str_mv |
1525-4135 |
identifier_str_mv |
CARVALHO FILHO, E. M. et al. Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors. Journal of Acquired Immune Deficiency Syndromes, v. 27, n. 1, p. 1-6, 2001. 1525-4135 |
url |
https://www.arca.fiocruz.br/handle/icict/8148 |
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eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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