Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases - a comparative study of leishmaniasis and sporotrichosis
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/29257 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil. |
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Morgado, F. N.Carvalho, L. M. V. deSilva, J. LeiteSeba, A. J.Pimentel, M. I. F.Fagundes, A.Madeira, M. F.Lyra, M. R.Oliveira, M. M.Schubach, A. O.Silva, F. Conceição2018-10-03T13:49:32Z2018-10-03T13:49:32Z2018MORGADO, F. N. et al. Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases – a comparative study of leishmaniasis and sporotrichosis. Scientific Reports, v. 8, n. 2898, p. 1-10, Feb. 2018.2045-2322https://www.arca.fiocruz.br/handle/icict/2925710.1038/s41598-018-21277-1engNature ResearchDoenças infecciosas cutâneasInflamaçãoLeishmanioseEsporotricoseDestruição tecidualEstudo comparativoSporotrichosisLeishmaniasisInflammationTissue destructionSkin infectious diseasesComparative studyUnbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases - a comparative study of leishmaniasis and sporotrichosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmaniose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmaniose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmaniose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmaniose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Malacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmaniose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.The clinical presentations of skin diseases produced by different pathogens, as American tegumentary leishmaniasis (ATL) and sporotrichosis can be similar and possibly influenced by the skin immune system (SIS). The aim of the study was to understand the underlying mechanisms of skin inflammation produced by different pathogens. We used immunohistochemistry to analyze 96 patients: a- localized cutaneous leishmaniasis (LCL-ATL); b- sporotrichoid cutaneous leishmaniasis (SCL-ATL); c-lymphocutaneous (LC-SP); d- fixed (F-SP) sporotrichosis. LCL-ATL and SCL-ATL had a significantly higher percentage of CD8, FasL and NOS2 than sporotrichosis. In contrast, LC-SP had a substantially higher percentage of CD4, BCl2 and neutrophils than ATL lesions. These results indicated some differences in the profile of the in situ immune response suggesting that SIS is a complex, adaptable system capable of different responses to intracellular or extracellular pathogens. However, regardless of the etiological agents, the inflammatory reaction and clinical manifestations can be similar. SCL-ATL and LC-SP presented similarities in both clinical presentation and in situ inflammatory profile (CD3, CD22, neutrophils, macrophages). The clinical presentation of ATL and sporotrichosis could be explained by a combination of factors both of the host SIS and the etiological agent. The unbalanced host parasite relationship could result in atypical manifestations of skin disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/29257/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFN_morgado_etal_IOC_2018.pdfFN_morgado_etal_IOC_2018.pdfapplication/pdf1887666https://www.arca.fiocruz.br/bitstream/icict/29257/2/FN_morgado_etal_IOC_2018.pdfce46a9af439c574bc3e8597f0dce26cbMD52TEXTFN_morgado_etal_IOC_2018.pdf.txtFN_morgado_etal_IOC_2018.pdf.txtExtracted texttext/plain44343https://www.arca.fiocruz.br/bitstream/icict/29257/3/FN_morgado_etal_IOC_2018.pdf.txtd55c8888f5ffe748954f73402b063e2fMD53icict/292572019-06-12 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dc.title.pt_BR.fl_str_mv |
Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases - a comparative study of leishmaniasis and sporotrichosis |
title |
Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases - a comparative study of leishmaniasis and sporotrichosis |
spellingShingle |
Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases - a comparative study of leishmaniasis and sporotrichosis Morgado, F. N. Doenças infecciosas cutâneas Inflamação Leishmaniose Esporotricose Destruição tecidual Estudo comparativo Sporotrichosis Leishmaniasis Inflammation Tissue destruction Skin infectious diseases Comparative study |
title_short |
Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases - a comparative study of leishmaniasis and sporotrichosis |
title_full |
Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases - a comparative study of leishmaniasis and sporotrichosis |
title_fullStr |
Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases - a comparative study of leishmaniasis and sporotrichosis |
title_full_unstemmed |
Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases - a comparative study of leishmaniasis and sporotrichosis |
title_sort |
Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases - a comparative study of leishmaniasis and sporotrichosis |
author |
Morgado, F. N. |
author_facet |
Morgado, F. N. Carvalho, L. M. V. de Silva, J. Leite Seba, A. J. Pimentel, M. I. F. Fagundes, A. Madeira, M. F. Lyra, M. R. Oliveira, M. M. Schubach, A. O. Silva, F. Conceição |
author_role |
author |
author2 |
Carvalho, L. M. V. de Silva, J. Leite Seba, A. J. Pimentel, M. I. F. Fagundes, A. Madeira, M. F. Lyra, M. R. Oliveira, M. M. Schubach, A. O. Silva, F. Conceição |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Morgado, F. N. Carvalho, L. M. V. de Silva, J. Leite Seba, A. J. Pimentel, M. I. F. Fagundes, A. Madeira, M. F. Lyra, M. R. Oliveira, M. M. Schubach, A. O. Silva, F. Conceição |
dc.subject.other.pt_BR.fl_str_mv |
Doenças infecciosas cutâneas Inflamação Leishmaniose Esporotricose Destruição tecidual Estudo comparativo |
topic |
Doenças infecciosas cutâneas Inflamação Leishmaniose Esporotricose Destruição tecidual Estudo comparativo Sporotrichosis Leishmaniasis Inflammation Tissue destruction Skin infectious diseases Comparative study |
dc.subject.en.pt_BR.fl_str_mv |
Sporotrichosis Leishmaniasis Inflammation Tissue destruction Skin infectious diseases Comparative study |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-10-03T13:49:32Z |
dc.date.available.fl_str_mv |
2018-10-03T13:49:32Z |
dc.date.issued.fl_str_mv |
2018 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MORGADO, F. N. et al. Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases – a comparative study of leishmaniasis and sporotrichosis. Scientific Reports, v. 8, n. 2898, p. 1-10, Feb. 2018. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/29257 |
dc.identifier.issn.pt_BR.fl_str_mv |
2045-2322 |
dc.identifier.doi.none.fl_str_mv |
10.1038/s41598-018-21277-1 |
identifier_str_mv |
MORGADO, F. N. et al. Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases – a comparative study of leishmaniasis and sporotrichosis. Scientific Reports, v. 8, n. 2898, p. 1-10, Feb. 2018. 2045-2322 10.1038/s41598-018-21277-1 |
url |
https://www.arca.fiocruz.br/handle/icict/29257 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Nature Research |
publisher.none.fl_str_mv |
Nature Research |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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