Hepatitis C virus genotypes in a northeastern area of Brazil.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2000 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7571 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil |
| id |
CRUZ_46acd0f8580e3228c5bc741b8a8c369e |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/7571 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Silva, Luciano KalabricParaná, RaymundoSouza, Sérgio P.Kay, AlanTrépo, ChristianBerby, FrançoiseSantana, Nelma Pereira deCotrim, Helma PinchemelLyra, Luiz Guilherme CostaReis, Mitermayer Galvão dos2014-05-02T17:51:10Z2014-05-02T17:51:10Z2000SILVA, L. K. et al. Hepatitis C virus genotypes in a northeastern area of Brazil. American Journal of Tropical Medicine and Hygiene, v. 62, n. 2, p. 257-260, 2000.0002-9637https://www.arca.fiocruz.br/handle/icict/7571engAmerican Society of Tropical Medicine and HygieneHepatitis C virus genotypes in a northeastern area of Brazil.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilHospital Universitário Professor Edgard Santos. ,Laboratório Gastroenterologia e Hepatologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilInstitut National de la Santé et de la Recherche Médicale Unité. Lyon, FranceInstitut National de la Santé et de la Recherche Médicale Unité. Lyon, FranceInstitut National de la Santé et de la Recherche Médicale Unité. Lyon, FranceHospital Universitário Professor Edgard Santos. ,Laboratório Gastroenterologia e Hepatologia. Salvador, BA, BrasilHospital Universitário Professor Edgard Santos. ,Laboratório Gastroenterologia e Hepatologia. Salvador, BA, BrasilHospital Universitário Professor Edgard Santos. ,Laboratório Gastroenterologia e Hepatologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilWe used a reverse transcription-polymerase chain reaction (RT-PCR) to obtain the genotypes of circulating hepatitis C virus (HCV) in patients from a Gastro-Hepatology Unit in the city of Salvador (Bahia State) in northeastern Brazil. Viral RNA was detected in 83 (65.4%) of 127 anti-HCV seropositive serum samples. Positivity was significantly associated with alterations in levels of aspartate aminotransferase and alanine aminotransferase (P < 0.05). Genotyping of HCV was performed by RT-PCR using genotype-specific primers from the core region: 24.1% were infected with subtype 1a, 38.6% with 1b, 3.6% with 2, 21.7% with 3a, and 12.0% with a mixed genotype. There was no difference in genotype distribution when compared with results from other Brazilian locations. Surprisingly, the high frequency of genotype 3 in Brazilian samples continues to be different from that reported around the world and warrants further investigationHepacivirus/genéticaHepatite C/virologiaAdolescenteAdultoIdosoAlanina Transaminase/sangueAspartato Aminotransferases/sangueSouthern BlottingBrasil/epidemiologiaPrimers do DNA/químicaDNA Viral/químicaGenótipoFemininoHepacivirus/químicaHepatite C/epidemiologiaTécnicas ImunoenzimáticasHumanosMasculinoMeia-IdadeRNA Viral/químicaReação em Cadeia da Polimerase Via Transcriptase ReversaEstudos Soroepidemiológicosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSilva LK Hepatitis C virus genotypes....pdfSilva LK Hepatitis C virus genotypes....pdfapplication/pdf44851https://www.arca.fiocruz.br/bitstream/icict/7571/1/Silva%20LK%20Hepatitis%20C%20virus%20genotypes....pdffca0a98c8d5466e0d87b0d663bb37fe7MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7571/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTSilva LK Hepatitis C virus genotypes....pdf.txtSilva LK Hepatitis C virus genotypes....pdf.txtExtracted texttext/plain24320https://www.arca.fiocruz.br/bitstream/icict/7571/5/Silva%20LK%20Hepatitis%20C%20virus%20genotypes....pdf.txt4b9284c83aec011591b309c48f148b6bMD55THUMBNAILSilva LK Hepatitis C virus genotypes....pdf.jpgSilva LK Hepatitis C virus genotypes....pdf.jpgGenerated Thumbnailimage/jpeg1823https://www.arca.fiocruz.br/bitstream/icict/7571/4/Silva%20LK%20Hepatitis%20C%20virus%20genotypes....pdf.jpgc72cb2cde3310c356289cdf8621f1c9bMD54icict/75712023-03-15 14:33:10.918oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:10Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Hepatitis C virus genotypes in a northeastern area of Brazil. |
| title |
Hepatitis C virus genotypes in a northeastern area of Brazil. |
| spellingShingle |
Hepatitis C virus genotypes in a northeastern area of Brazil. Silva, Luciano Kalabric Hepacivirus/genética Hepatite C/virologia Adolescente Adulto Idoso Alanina Transaminase/sangue Aspartato Aminotransferases/sangue Southern Blotting Brasil/epidemiologia Primers do DNA/química DNA Viral/química Genótipo Feminino Hepacivirus/química Hepatite C/epidemiologia Técnicas Imunoenzimáticas Humanos Masculino Meia-Idade RNA Viral/química Reação em Cadeia da Polimerase Via Transcriptase Reversa Estudos Soroepidemiológicos |
| title_short |
Hepatitis C virus genotypes in a northeastern area of Brazil. |
| title_full |
Hepatitis C virus genotypes in a northeastern area of Brazil. |
| title_fullStr |
Hepatitis C virus genotypes in a northeastern area of Brazil. |
| title_full_unstemmed |
Hepatitis C virus genotypes in a northeastern area of Brazil. |
| title_sort |
Hepatitis C virus genotypes in a northeastern area of Brazil. |
| author |
Silva, Luciano Kalabric |
| author_facet |
Silva, Luciano Kalabric Paraná, Raymundo Souza, Sérgio P. Kay, Alan Trépo, Christian Berby, Françoise Santana, Nelma Pereira de Cotrim, Helma Pinchemel Lyra, Luiz Guilherme Costa Reis, Mitermayer Galvão dos |
| author_role |
author |
| author2 |
Paraná, Raymundo Souza, Sérgio P. Kay, Alan Trépo, Christian Berby, Françoise Santana, Nelma Pereira de Cotrim, Helma Pinchemel Lyra, Luiz Guilherme Costa Reis, Mitermayer Galvão dos |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Luciano Kalabric Paraná, Raymundo Souza, Sérgio P. Kay, Alan Trépo, Christian Berby, Françoise Santana, Nelma Pereira de Cotrim, Helma Pinchemel Lyra, Luiz Guilherme Costa Reis, Mitermayer Galvão dos |
| dc.subject.decs.pt_BR.fl_str_mv |
Hepacivirus/genética Hepatite C/virologia Adolescente Adulto Idoso Alanina Transaminase/sangue Aspartato Aminotransferases/sangue Southern Blotting Brasil/epidemiologia Primers do DNA/química DNA Viral/química Genótipo Feminino Hepacivirus/química Hepatite C/epidemiologia Técnicas Imunoenzimáticas Humanos Masculino Meia-Idade RNA Viral/química Reação em Cadeia da Polimerase Via Transcriptase Reversa Estudos Soroepidemiológicos |
| topic |
Hepacivirus/genética Hepatite C/virologia Adolescente Adulto Idoso Alanina Transaminase/sangue Aspartato Aminotransferases/sangue Southern Blotting Brasil/epidemiologia Primers do DNA/química DNA Viral/química Genótipo Feminino Hepacivirus/química Hepatite C/epidemiologia Técnicas Imunoenzimáticas Humanos Masculino Meia-Idade RNA Viral/química Reação em Cadeia da Polimerase Via Transcriptase Reversa Estudos Soroepidemiológicos |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil |
| publishDate |
2000 |
| dc.date.issued.fl_str_mv |
2000 |
| dc.date.accessioned.fl_str_mv |
2014-05-02T17:51:10Z |
| dc.date.available.fl_str_mv |
2014-05-02T17:51:10Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
SILVA, L. K. et al. Hepatitis C virus genotypes in a northeastern area of Brazil. American Journal of Tropical Medicine and Hygiene, v. 62, n. 2, p. 257-260, 2000. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/7571 |
| dc.identifier.issn.none.fl_str_mv |
0002-9637 |
| identifier_str_mv |
SILVA, L. K. et al. Hepatitis C virus genotypes in a northeastern area of Brazil. American Journal of Tropical Medicine and Hygiene, v. 62, n. 2, p. 257-260, 2000. 0002-9637 |
| url |
https://www.arca.fiocruz.br/handle/icict/7571 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
American Society of Tropical Medicine and Hygiene |
| publisher.none.fl_str_mv |
American Society of Tropical Medicine and Hygiene |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/7571/1/Silva%20LK%20Hepatitis%20C%20virus%20genotypes....pdf https://www.arca.fiocruz.br/bitstream/icict/7571/2/license.txt https://www.arca.fiocruz.br/bitstream/icict/7571/5/Silva%20LK%20Hepatitis%20C%20virus%20genotypes....pdf.txt https://www.arca.fiocruz.br/bitstream/icict/7571/4/Silva%20LK%20Hepatitis%20C%20virus%20genotypes....pdf.jpg |
| bitstream.checksum.fl_str_mv |
fca0a98c8d5466e0d87b0d663bb37fe7 7d48279ffeed55da8dfe2f8e81f3b81f 4b9284c83aec011591b309c48f148b6b c72cb2cde3310c356289cdf8621f1c9b |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1798324685071450112 |