Systemic Inflammation in Pregnant Women With Latent Tuberculosis Infection

Detalhes bibliográficos
Autor(a) principal: Naik, Shilpa
Data de Publicação: 2021
Outros Autores: Alexander, Mallika, Kumar, Pavan, Kulkarni, Vandana, Deshpande, Prasad, Yadana, Su, Leu, Cheng-Shiun, Pereira, Mariana Araújo, Andrade, Bruno Bezerril de, Bhosale, Ramesh, Babu, Subash, Gupta, Amita, Mathad, Jyoti S., Shivakoti, Rupak
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50222
Resumo: 1 Byramjee-Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Research Site, Pune, India, 2 Department of Obstetrics and Gynecology, Byramjee Jeejeebhoy Government Medical College, Pune, India, 3 International Center for Excellence in Research, National Institutes of Health, National Institute for Research in Tuberculosis, Chennai, India, 4 Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, United States, 5 Department of Biostatistics, Columbia University Mailman School of Public Health, New York, NY, United States, 6 Instituto Goncalo Moniz, Fundac¸ão Oswaldo Cruz, Salvador, Brazil, 7 Multinational Organization Network Sponsoring Translational and Epidemiological Research, Fundac¸ão Jose´ Silveira, New York, NY, Brazil, 8 Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Brazil, 9 Curso de Medicina, Faculdade de Tecnologia e Cieˆ ncias, Salvador, Brazil, 10 Escola de Medicina, Universidade Salvador (UNIFACS), Laureate International Universities, Salvador, Brazil, 11 Curso de Medicina, Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador, Brazil, 12 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 13 Department of Medicine, Weill Cornell Medical College, New York, NY, United States
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spelling Naik, ShilpaAlexander, MallikaKumar, PavanKulkarni, VandanaDeshpande, PrasadYadana, SuLeu, Cheng-ShiunPereira, Mariana AraújoAndrade, Bruno Bezerril deBhosale, RameshBabu, SubashGupta, AmitaMathad, Jyoti S.Shivakoti, Rupak2021-12-09T12:03:49Z2021-12-09T12:03:49Z2021NAIK, Shilpa et al. Systemic Inflammation in Pregnant Women With Latent Tuberculosis Infection. Frontiers in Immunology, 2021.1664-3224https://www.arca.fiocruz.br/handle/icict/5022210.3389/fimmu.2020.5876171 Byramjee-Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Research Site, Pune, India, 2 Department of Obstetrics and Gynecology, Byramjee Jeejeebhoy Government Medical College, Pune, India, 3 International Center for Excellence in Research, National Institutes of Health, National Institute for Research in Tuberculosis, Chennai, India, 4 Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, United States, 5 Department of Biostatistics, Columbia University Mailman School of Public Health, New York, NY, United States, 6 Instituto Goncalo Moniz, Fundac¸ão Oswaldo Cruz, Salvador, Brazil, 7 Multinational Organization Network Sponsoring Translational and Epidemiological Research, Fundac¸ão Jose´ Silveira, New York, NY, Brazil, 8 Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Brazil, 9 Curso de Medicina, Faculdade de Tecnologia e Cieˆ ncias, Salvador, Brazil, 10 Escola de Medicina, Universidade Salvador (UNIFACS), Laureate International Universities, Salvador, Brazil, 11 Curso de Medicina, Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador, Brazil, 12 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 13 Department of Medicine, Weill Cornell Medical College, New York, NY, United StatesUnited States National Institutes of Health, NIH, Bethesda, MD, USA (R00HD089753 to RS and R01HD081929 to AG). JSM received support from NIAID (K23AI129854). Additional support for this work was the NIH-funded Johns Hopkins Baltimore-Washington-India Clinical Trials Unit for NIAID Networks (U01AI069465 to AG). BA is a senior investigator from the Conselho Nacional de Desenvolvimento Cientı́fico e Tecnológico (CNPq), Brazil. MA-P received a research fellowship from the Coordenação de Aperfeiçoamento de Pessoal de Nı́vel Superior (CAPES; finance code 001). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH."Múltipla ver em Notas"Background: Recent studies in adults have characterized differences in systemic inflammation between adults with and without latent tuberculosis infection (LTBI+ vs. LTBI−). Potential differences in systemic inflammation by LTBI status has not been assess in pregnant women. Methods: We conducted a cohort study of 155 LTBI+ and 65 LTBI− pregnant women, stratified by HIV status, attending an antenatal clinic in Pune, India. LTBI status was assessed by interferon gamma release assay. Plasma was used to measure systemic inflammation markers using immunoassays: IFNb, CRP, AGP, I-FABP, IFNg, IL-1b, soluble CD14 (sCD14), sCD163, TNF, IL-6, IL-17a and IL-13. Linear regression models were fit to test the association of LTBI status with each inflammation marker. We also conducted an exploratory analysis using logistic regression to test the association of inflammatory markers with TB progression. Results: Study population was a median age of 23 (Interquartile range: 21–27), 28% undernourished (mid-upper arm circumference (MUAC) <23 cm), 12% were vegetarian, 10% with gestational diabetes and 32% with HIV. In multivariable models, LTBI+ women had significantly lower levels of third trimester AGP, IL1b, sCD163, IL-6 and IL-17a. Interestingly, in exploratory analysis, LTBI+ TB progressors had significantly higher levels of IL1b, IL-6 and IL-13 in multivariable models compared to LTBI+ non-progressors. Conclusions: Our data shows a distinct systemic immune profile in LTBI+ pregnant women compared to LTBI− women. Data from our exploratory analysis suggest that LTBI+ TB progressors do not have this immune profile, suggesting negative association of this profile with TB progression. If other studies confirm these differences by LTBI status and show a causal relationship with TB progression, this immune profile could identify subsets of LTBI+ pregnant women at high risk for TB progression and who can be targeted for preventative therapy.engFrontiers MediaTuberculosa latenteInfecçãoInflamaçãoGravidezCitocinasLatent tuberculosis infectionTuberculosis diseaseInflammationPregnancyCytokinesLTBITBSystemic Inflammation in Pregnant Women With Latent Tuberculosis Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/50222/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALNaik, Shilpa. Systemic....pdfNaik, Shilpa. Systemic....pdfapplication/pdf926228https://www.arca.fiocruz.br/bitstream/icict/50222/2/Naik%2c%20Shilpa.%20Systemic....pdf0edd6a52ab3baa5dba80d387ba9e4599MD52icict/502222023-03-15 14:34:32.089oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:32Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Systemic Inflammation in Pregnant Women With Latent Tuberculosis Infection
title Systemic Inflammation in Pregnant Women With Latent Tuberculosis Infection
spellingShingle Systemic Inflammation in Pregnant Women With Latent Tuberculosis Infection
Naik, Shilpa
Tuberculosa latente
Infecção
Inflamação
Gravidez
Citocinas
Latent tuberculosis infection
Tuberculosis disease
Inflammation
Pregnancy
Cytokines
LTBI
TB
title_short Systemic Inflammation in Pregnant Women With Latent Tuberculosis Infection
title_full Systemic Inflammation in Pregnant Women With Latent Tuberculosis Infection
title_fullStr Systemic Inflammation in Pregnant Women With Latent Tuberculosis Infection
title_full_unstemmed Systemic Inflammation in Pregnant Women With Latent Tuberculosis Infection
title_sort Systemic Inflammation in Pregnant Women With Latent Tuberculosis Infection
author Naik, Shilpa
author_facet Naik, Shilpa
Alexander, Mallika
Kumar, Pavan
Kulkarni, Vandana
Deshpande, Prasad
Yadana, Su
Leu, Cheng-Shiun
Pereira, Mariana Araújo
Andrade, Bruno Bezerril de
Bhosale, Ramesh
Babu, Subash
Gupta, Amita
Mathad, Jyoti S.
Shivakoti, Rupak
author_role author
author2 Alexander, Mallika
Kumar, Pavan
Kulkarni, Vandana
Deshpande, Prasad
Yadana, Su
Leu, Cheng-Shiun
Pereira, Mariana Araújo
Andrade, Bruno Bezerril de
Bhosale, Ramesh
Babu, Subash
Gupta, Amita
Mathad, Jyoti S.
Shivakoti, Rupak
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Naik, Shilpa
Alexander, Mallika
Kumar, Pavan
Kulkarni, Vandana
Deshpande, Prasad
Yadana, Su
Leu, Cheng-Shiun
Pereira, Mariana Araújo
Andrade, Bruno Bezerril de
Bhosale, Ramesh
Babu, Subash
Gupta, Amita
Mathad, Jyoti S.
Shivakoti, Rupak
dc.subject.other.pt_BR.fl_str_mv Tuberculosa latente
Infecção
Inflamação
Gravidez
Citocinas
topic Tuberculosa latente
Infecção
Inflamação
Gravidez
Citocinas
Latent tuberculosis infection
Tuberculosis disease
Inflammation
Pregnancy
Cytokines
LTBI
TB
dc.subject.en.pt_BR.fl_str_mv Latent tuberculosis infection
Tuberculosis disease
Inflammation
Pregnancy
Cytokines
LTBI
TB
description 1 Byramjee-Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Research Site, Pune, India, 2 Department of Obstetrics and Gynecology, Byramjee Jeejeebhoy Government Medical College, Pune, India, 3 International Center for Excellence in Research, National Institutes of Health, National Institute for Research in Tuberculosis, Chennai, India, 4 Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, United States, 5 Department of Biostatistics, Columbia University Mailman School of Public Health, New York, NY, United States, 6 Instituto Goncalo Moniz, Fundac¸ão Oswaldo Cruz, Salvador, Brazil, 7 Multinational Organization Network Sponsoring Translational and Epidemiological Research, Fundac¸ão Jose´ Silveira, New York, NY, Brazil, 8 Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Brazil, 9 Curso de Medicina, Faculdade de Tecnologia e Cieˆ ncias, Salvador, Brazil, 10 Escola de Medicina, Universidade Salvador (UNIFACS), Laureate International Universities, Salvador, Brazil, 11 Curso de Medicina, Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador, Brazil, 12 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 13 Department of Medicine, Weill Cornell Medical College, New York, NY, United States
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-09T12:03:49Z
dc.date.available.fl_str_mv 2021-12-09T12:03:49Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NAIK, Shilpa et al. Systemic Inflammation in Pregnant Women With Latent Tuberculosis Infection. Frontiers in Immunology, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50222
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2020.587617
identifier_str_mv NAIK, Shilpa et al. Systemic Inflammation in Pregnant Women With Latent Tuberculosis Infection. Frontiers in Immunology, 2021.
1664-3224
10.3389/fimmu.2020.587617
url https://www.arca.fiocruz.br/handle/icict/50222
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Frontiers Media
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collection Repositório Institucional da FIOCRUZ (ARCA)
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