Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/32242 |
Resumo: | 2020-03-07 |
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Duque, Maria Cristina de OliveiraSilva, José Jayme QuintãoSoares, Priscilla Andrade OliveiraMagalhães, Rodrigo SousaHorta, Adriene Paiva AraújoPaes, Lucia Regina BrahimLyra, Marcelo RosandiskiPimentel, Maria Inês FernandesAntonio, Liliane de FátimaVasconcellos, Érica de Camargo Ferreira eSaheki, Maurício NaotoMarzochi, Mauro Celio de AlmeidaValete-Rosalino, Cláudia MariaSchubach, Armando de Oliveira2019-03-27T13:04:53Z2019-03-27T13:04:53Z2019DUQUE, Maria Cristina de Oliveira et al. Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit. Acta Tropica, v. 193, p. 176-182, 2019.0001-706Xhttps://www.arca.fiocruz.br/handle/icict/3224210.1016/j.actatropica.2019.03.007engElsevierComparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unitinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-03-07Secretaria Municipal de Saúde. Timóteo, MG, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Programa de Pós-Graduação Stricto Sensu em Pesquisa Clínica. Rio de Janeiro, RJ, Brasil.Secretaria Municipal de Saúde. Timóteo, MG, Brasil.Private Clinic. Coronel Fabriciano, MG, Brazil.Private Clinic. Ipatinga, MG, Brazil.Secretaria Municipal de Saúde. Timóteo, MG, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil / Fundação Técnico Educacional Souza Marques. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Programa de Produtividade em Pesquisa. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil /Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Departamento de Otorrinolaringologia e Oftalmologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Programa de Produtividade em Pesquisa. Brasília, DF, Brasil /Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro. Programa Cientista do Nosso Estado. Rio de Janeiro, RJ, Brasil.Cutaneous leishmaniasis (CL) is not a life-threatening condition. However, its treatment can cause serious adverse effects and may sometimes lead to death. Recently, safer local treatments have been included among therapies acceptable to New World CL cases, but the use of intralesional meglumine antimoniate (IL-MA) is recommended to be performed in reference centers, for patients with single cutaneous lesions < 3 cm in diameter at any location except the head and periarticular regions; the volume of injected MA should not exceed 5 mL. In this study we compared two groups of patients with CL treated with MA in a primary health care unit in Brazil. Patients were treated with systemic MA (n = 76) or IL-MA (n = 30). In the IL-MA group, 93% of patients had one or more of the following lesion characteristics: two or more lesions, lesions > 3 cm in diameter, lesions located in the head or in periarticular regions, or had been administered IL-MA volumes > 5 mL. Patients responded well (68.4% and 66.7% for the MA and IL-MA groups, respectively). When a second cycle of treatment was necessary, the responses were 72.4% and 90%, respectively. There were no significant differences between groups. In the IL-MA group, 43% had mild to moderate adverse effects, without needing treatment discontinuation. Results suggest that the treatment of CL lesions with IL-MA is simple, efficient, and safe.American tegumentary leishmaniasisCutaneous leishmaniasisTherapyMeglumine antimoniateIntralesionalinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/32242/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Duque_Maria_etal_INI_2019.pdfve_Duque_Maria_etal_INI_2019.pdfapplication/pdf692057https://www.arca.fiocruz.br/bitstream/icict/32242/2/ve_Duque_Maria_etal_INI_2019.pdf6ff025ebd53e613327433c522b87d1f3MD52TEXTve_Duque_Maria_etal_INI_2019.pdf.txtve_Duque_Maria_etal_INI_2019.pdf.txtExtracted texttext/plain48302https://www.arca.fiocruz.br/bitstream/icict/32242/3/ve_Duque_Maria_etal_INI_2019.pdf.txt6eb8781ec39a4f3c0eb4b2dea9ccf09cMD53icict/322422021-03-24 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dc.title.pt_BR.fl_str_mv |
Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit |
title |
Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit |
spellingShingle |
Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit Duque, Maria Cristina de Oliveira American tegumentary leishmaniasis Cutaneous leishmaniasis Therapy Meglumine antimoniate Intralesional |
title_short |
Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit |
title_full |
Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit |
title_fullStr |
Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit |
title_full_unstemmed |
Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit |
title_sort |
Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit |
author |
Duque, Maria Cristina de Oliveira |
author_facet |
Duque, Maria Cristina de Oliveira Silva, José Jayme Quintão Soares, Priscilla Andrade Oliveira Magalhães, Rodrigo Sousa Horta, Adriene Paiva Araújo Paes, Lucia Regina Brahim Lyra, Marcelo Rosandiski Pimentel, Maria Inês Fernandes Antonio, Liliane de Fátima Vasconcellos, Érica de Camargo Ferreira e Saheki, Maurício Naoto Marzochi, Mauro Celio de Almeida Valete-Rosalino, Cláudia Maria Schubach, Armando de Oliveira |
author_role |
author |
author2 |
Silva, José Jayme Quintão Soares, Priscilla Andrade Oliveira Magalhães, Rodrigo Sousa Horta, Adriene Paiva Araújo Paes, Lucia Regina Brahim Lyra, Marcelo Rosandiski Pimentel, Maria Inês Fernandes Antonio, Liliane de Fátima Vasconcellos, Érica de Camargo Ferreira e Saheki, Maurício Naoto Marzochi, Mauro Celio de Almeida Valete-Rosalino, Cláudia Maria Schubach, Armando de Oliveira |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Duque, Maria Cristina de Oliveira Silva, José Jayme Quintão Soares, Priscilla Andrade Oliveira Magalhães, Rodrigo Sousa Horta, Adriene Paiva Araújo Paes, Lucia Regina Brahim Lyra, Marcelo Rosandiski Pimentel, Maria Inês Fernandes Antonio, Liliane de Fátima Vasconcellos, Érica de Camargo Ferreira e Saheki, Maurício Naoto Marzochi, Mauro Celio de Almeida Valete-Rosalino, Cláudia Maria Schubach, Armando de Oliveira |
dc.subject.en.pt_BR.fl_str_mv |
American tegumentary leishmaniasis Cutaneous leishmaniasis Therapy Meglumine antimoniate Intralesional |
topic |
American tegumentary leishmaniasis Cutaneous leishmaniasis Therapy Meglumine antimoniate Intralesional |
description |
2020-03-07 |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-03-27T13:04:53Z |
dc.date.available.fl_str_mv |
2019-03-27T13:04:53Z |
dc.date.issued.fl_str_mv |
2019 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
DUQUE, Maria Cristina de Oliveira et al. Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit. Acta Tropica, v. 193, p. 176-182, 2019. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/32242 |
dc.identifier.issn.pt_BR.fl_str_mv |
0001-706X |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.actatropica.2019.03.007 |
identifier_str_mv |
DUQUE, Maria Cristina de Oliveira et al. Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit. Acta Tropica, v. 193, p. 176-182, 2019. 0001-706X 10.1016/j.actatropica.2019.03.007 |
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https://www.arca.fiocruz.br/handle/icict/32242 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Elsevier |
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Elsevier |
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