Infection with Leishmania (Leishmania) infantum of 0 to 18-Month-Old Children Living in a Visceral Leishmaniasis-Endemic Area in Brazil

Detalhes bibliográficos
Autor(a) principal: Maciel, Danielle Borges
Data de Publicação: 2014
Outros Autores: Silva, Thaıs Almeida Marques, Gomes, Luciana Inacia, Oliveira, Edward josé de, Tiburcio, Monique Gomes Salles, Oliveira, Rafael Faria de, Avelar, Daniel, Barbosa, Jose Ronaldo, Furtado, Eliana, Rabello, Ana Lucia Teles, Silva, Luciana de Almeida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11446
Resumo: Universidade Federal do Triangulo Mineiro. Programa de Pos Graduação em Medicina Tropical e Infectologia. Uberaba, MG, Brasil
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spelling Maciel, Danielle BorgesSilva, Thaıs Almeida MarquesGomes, Luciana InaciaOliveira, Edward josé deTiburcio, Monique Gomes SallesOliveira, Rafael Faria deAvelar, DanielBarbosa, Jose RonaldoFurtado, ElianaRabello, Ana Lucia TelesSilva, Luciana de Almeida2015-08-13T17:08:35Z2015-08-13T17:08:35Z2014MACIEL, Danielle Borges et al. Infection with Leishmania (Leishmania) infantum of 0 to 18-Month-Old Children Living in a Visceral Leishmaniasis-Endemic Area in Brazil. Am. J. Trop. M., vol. 91, n. 2, p. 329-335, 2014.0002-9637https://www.arca.fiocruz.br/handle/icict/1144610.4269/ajtmh.13-0418engAmerican Society of Tropical Medicine and HygieneInfection with Leishmania (Leishmania) infantum of 0 to 18-Month-Old Children Living in a Visceral Leishmaniasis-Endemic Area in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Triangulo Mineiro. Programa de Pos Graduação em Medicina Tropical e Infectologia. Uberaba, MG, BrasilFundacao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Pesquisas Clınicas. Belo Horizonte, MG, BrasilFundacao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Pesquisas Clınicas. Belo Horizonte, MG, BrasilFundacao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Pesquisas Clınicas. Belo Horizonte, MG, BrasilUniversidade Federal do Triangulo Mineiro. Programa de Pos Graduação em Medicina Tropical e Infectologia. Uberaba, MG, BrasilUniversidade Federal do Triangulo Mineiro. Programa de Pos Graduação em Medicina Tropical e Infectologia. Uberaba, MG, BrasilFundacao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Pesquisas Clınicas. Belo Horizonte, MG, BrasilFundacao Ezequiel Dias. Belo Horizonte, MG, BrasilFundacao Ezequiel Dias. Belo Horizonte, MG, BrasilFundacao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Pesquisas Clınicas. Belo Horizonte, MG, BrasilUniversidade Federal do Triangulo Mineiro. Programa de Pos Graduação em Doenças Infecciosas e Parasitarias. Uberaba, MG, BrasilThe diagnosis of Leishmania (Leishmania) infantum infection in children from birth may serve as a reference for the early identification of cases that would progress to classical visceral leishmaniasis (VL) in endemic areas. This study prospectively evaluated newborns of mothers living in the municipality of Paracatu, Minas Gerais, Brazil. The infants were followed up at 6-month intervals by clinical examination, serological tests (immunofluorescence [IIF] and enzyme-linked immunosorbent assay with rK39 [ELISA-rK39]) and polymerase chain reaction (PCR) until they had completed 18 months of age. A total of 166 pregnant women were included to evaluate the possible transfer of antibodies or even congenital transmission. Twenty-two of the women tested positive by IIF, four by ELISA-rK39, and one by PCR. Three infants of the 25 women with some positive test results were also positive in the first test (one by IIF, one by ELISA-rK39, and the third by ELISA-rK39 and PCR). One hundred and sixty infants were included in the study; of these, 43 had at least one positive sample over time. However, agreement between tests was low. Follow-up of children with a positive result in the tests studied revealed no progression to classical disease within a period of 18 months. In contrast, two children with negative IIF, PCR, and ELISA-rK39 results developed classical VL at 9 and 12 months of age. In conclusion, a positive test result was variable and sometimes temporary and agreement between tests was low. Therefore, the early diagnosis of Leishmania infection was not associated with the early identification of cases that would progress to classical VL in the endemic area studied.Enzyme-Linked Immunosorbent AssayFluorescent Antibody TechniqueLeishmania infantum/immunologyLeishmania infantum/isolation & purificationLeishmaniasis, Visceral/immunologyPolymerase Chain Reactioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11446/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALInfection with Leishmania (Leishmania) infantum of 0 to 18-Month-Old Children Living in a Visceral Leishmaniasis-Endemic Area in Brazil.pdfInfection with Leishmania (Leishmania) infantum of 0 to 18-Month-Old Children Living in a Visceral Leishmaniasis-Endemic Area in Brazil.pdfapplication/pdf697319https://www.arca.fiocruz.br/bitstream/icict/11446/2/Infection%20with%20Leishmania%20%28Leishmania%29%20infantum%20of%200%20to%2018-Month-Old%20Children%20Living%20in%20a%20Visceral%20Leishmaniasis-Endemic%20Area%20in%20Brazil.pdf7b0db396e4fed4db34f5776602785f9cMD52TEXTInfection with Leishmania (Leishmania) infantum of 0 to 18-Month-Old Children Living in a Visceral Leishmaniasis-Endemic Area in Brazil.pdf.txtInfection with Leishmania (Leishmania) infantum of 0 to 18-Month-Old Children Living in a Visceral Leishmaniasis-Endemic Area in Brazil.pdf.txtExtracted texttext/plain38131https://www.arca.fiocruz.br/bitstream/icict/11446/3/Infection%20with%20Leishmania%20%28Leishmania%29%20infantum%20of%200%20to%2018-Month-Old%20Children%20Living%20in%20a%20Visceral%20Leishmaniasis-Endemic%20Area%20in%20Brazil.pdf.txt79387eef586f84e44f35f67ac4fc42c0MD53icict/114462019-06-19 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dc.title.pt_BR.fl_str_mv Infection with Leishmania (Leishmania) infantum of 0 to 18-Month-Old Children Living in a Visceral Leishmaniasis-Endemic Area in Brazil
title Infection with Leishmania (Leishmania) infantum of 0 to 18-Month-Old Children Living in a Visceral Leishmaniasis-Endemic Area in Brazil
spellingShingle Infection with Leishmania (Leishmania) infantum of 0 to 18-Month-Old Children Living in a Visceral Leishmaniasis-Endemic Area in Brazil
Maciel, Danielle Borges
Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique
Leishmania infantum/immunology
Leishmania infantum/isolation & purification
Leishmaniasis, Visceral/immunology
Polymerase Chain Reaction
title_short Infection with Leishmania (Leishmania) infantum of 0 to 18-Month-Old Children Living in a Visceral Leishmaniasis-Endemic Area in Brazil
title_full Infection with Leishmania (Leishmania) infantum of 0 to 18-Month-Old Children Living in a Visceral Leishmaniasis-Endemic Area in Brazil
title_fullStr Infection with Leishmania (Leishmania) infantum of 0 to 18-Month-Old Children Living in a Visceral Leishmaniasis-Endemic Area in Brazil
title_full_unstemmed Infection with Leishmania (Leishmania) infantum of 0 to 18-Month-Old Children Living in a Visceral Leishmaniasis-Endemic Area in Brazil
title_sort Infection with Leishmania (Leishmania) infantum of 0 to 18-Month-Old Children Living in a Visceral Leishmaniasis-Endemic Area in Brazil
author Maciel, Danielle Borges
author_facet Maciel, Danielle Borges
Silva, Thaıs Almeida Marques
Gomes, Luciana Inacia
Oliveira, Edward josé de
Tiburcio, Monique Gomes Salles
Oliveira, Rafael Faria de
Avelar, Daniel
Barbosa, Jose Ronaldo
Furtado, Eliana
Rabello, Ana Lucia Teles
Silva, Luciana de Almeida
author_role author
author2 Silva, Thaıs Almeida Marques
Gomes, Luciana Inacia
Oliveira, Edward josé de
Tiburcio, Monique Gomes Salles
Oliveira, Rafael Faria de
Avelar, Daniel
Barbosa, Jose Ronaldo
Furtado, Eliana
Rabello, Ana Lucia Teles
Silva, Luciana de Almeida
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Maciel, Danielle Borges
Silva, Thaıs Almeida Marques
Gomes, Luciana Inacia
Oliveira, Edward josé de
Tiburcio, Monique Gomes Salles
Oliveira, Rafael Faria de
Avelar, Daniel
Barbosa, Jose Ronaldo
Furtado, Eliana
Rabello, Ana Lucia Teles
Silva, Luciana de Almeida
dc.subject.en.pt_BR.fl_str_mv Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique
Leishmania infantum/immunology
Leishmania infantum/isolation & purification
Leishmaniasis, Visceral/immunology
Polymerase Chain Reaction
topic Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique
Leishmania infantum/immunology
Leishmania infantum/isolation & purification
Leishmaniasis, Visceral/immunology
Polymerase Chain Reaction
description Universidade Federal do Triangulo Mineiro. Programa de Pos Graduação em Medicina Tropical e Infectologia. Uberaba, MG, Brasil
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-08-13T17:08:35Z
dc.date.available.fl_str_mv 2015-08-13T17:08:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MACIEL, Danielle Borges et al. Infection with Leishmania (Leishmania) infantum of 0 to 18-Month-Old Children Living in a Visceral Leishmaniasis-Endemic Area in Brazil. Am. J. Trop. M., vol. 91, n. 2, p. 329-335, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11446
dc.identifier.issn.none.fl_str_mv 0002-9637
dc.identifier.doi.none.fl_str_mv 10.4269/ajtmh.13-0418
identifier_str_mv MACIEL, Danielle Borges et al. Infection with Leishmania (Leishmania) infantum of 0 to 18-Month-Old Children Living in a Visceral Leishmaniasis-Endemic Area in Brazil. Am. J. Trop. M., vol. 91, n. 2, p. 329-335, 2014.
0002-9637
10.4269/ajtmh.13-0418
url https://www.arca.fiocruz.br/handle/icict/11446
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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