Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa Essential Oils: Chemical Composition, Antimicrobial and Antileishmanial Activity

Detalhes bibliográficos
Autor(a) principal: Teles, Amanda Mara
Data de Publicação: 2019
Outros Autores: Rosa, Taynan Dulce da Silva, Mouchrek, Adenilde Nascimento, Silva, Ana Lucia Abreu, Calabrese, Kátia da Silva, Souza, Fernando Almeida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32916
Resumo: Universidade Federal do Maranhão. Laboratório de Controle de Qualidade de Alimentos e Água. São Luís, MA, Brasil / Rede Nordeste de Biotecnologia. Ponto Focal Maranhão. São Luís, MA, Brasil.
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spelling Teles, Amanda MaraRosa, Taynan Dulce da SilvaMouchrek, Adenilde NascimentoSilva, Ana Lucia AbreuCalabrese, Kátia da SilvaSouza, Fernando Almeida2019-05-02T16:03:06Z2019-05-02T16:03:06Z2019TELES, Amanda Mara et al. Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa Essential Oils: Chemical Composition, Antimicrobial and Antileishmanial Activity. Evidence-Based Complementary and Alternative Medicine, Volume 2019, Article ID 2421965, 12p, 2019.1741-427Xhttps://www.arca.fiocruz.br/handle/icict/3291610.1155/2019/24216951741-4288engHindawi Publishing CorporationCinnamomum zeylanicumOriganum vulgareCurcuma longaÓleos essenciaisComposição químicaAtividade AntileishmanialAtividade antimicrobianaCinnamomum zeylanicumOriganum vulgareCurcuma longaEssential OilsAntileishmanial ActivityChemical CompositionAntimicrobial ActivityCinnamomum zeylanicum, Origanum vulgare, and Curcuma longa Essential Oils: Chemical Composition, Antimicrobial and Antileishmanial Activityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Maranhão. Laboratório de Controle de Qualidade de Alimentos e Água. São Luís, MA, Brasil / Rede Nordeste de Biotecnologia. Ponto Focal Maranhão. São Luís, MA, Brasil.Universidade Estadual do Maranhão. Mestrado em Ciência Animal. São Luís, MA, Brasil.Universidade Federal do Maranhão. Laboratório de Controle de Qualidade de Alimentos e Água. São Luís, MA, Brasil.Universidade Estadual do Maranhão. Mestrado em Ciência Animal. São Luís, MA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ. Brasil.Universidade Estadual do Maranhão. Mestrado em Ciência Animal. São Luís, MA, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ. Brasil.The resistance mechanisms of bacteria and protozoans have evidenced the need of discover new compounds with potential pharmaceutical activity against pathogenic microorganisms. Medicinal plants have been for centuries a promising alternative as sources of new drugs. The objective of this work was to evaluate the chemical composition, antimicrobial and antileishmanial activities of Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa essential oils. Chemical analysis was performed by gas chromatography-mass spectrometry. Antimicrobial activity was performed by disk diffusion and minimum inhibitory concentration (MIC) test. Antileishmanial activity was performed against antipromastigote and intracellular amastigote of Leishmania amazonensis. Cytotoxic and nitrite production were realized in BALB/c peritoneal macrophages. The major compounds of the essential oils were cinnamic aldehyde (46.30%) in C. zeylanicum, cis-p-menth-2-en-1-ol (33.88%) and linalyl acetate (13.90%) in O. vulgare, and turmerone (55.43%) in C. longa. The MIC showed significant antimicrobial activity of C. longa essential oil against S. aureus (83.3 ± 14.43 µg/mL). Antipromastigote activity showed IC50 values >500 µg/mL to C. zeylanicum, 308.4 ± 1.402 µg/mL to O. vulgare, and 405.5 ± 1.119 µg/mL to C. longa essential oil. Activity against intracellular amastigote of L. amazonensis showed IC50 of 63.3 ± 1.369 µg/mL and cytotoxic was not observed, resulting in selectivity index higher than 15.79 to parasite. C. longa essential oil decreased nitrite production in peritoneal macrophages, but not in Leishmania-infected cells. The chemical composition of the three essential oils is directly associated to its potential biological action, as the antimicrobial activity. C. longa presented a potent antileishmanial activity against promastigote and intracellular amastigote of L. amazonensis, although this activity is not linked to nitric oxide, since C. longa essential oil inhibits its production.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/32916/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALKatiaCalabrese_FernandoSouza_etal_IOC_2019.pdfKatiaCalabrese_FernandoSouza_etal_IOC_2019.pdfapplication/pdf2372762https://www.arca.fiocruz.br/bitstream/icict/32916/2/KatiaCalabrese_FernandoSouza_etal_IOC_2019.pdf33779edbe09d25db2c0126c5bd094e66MD52TEXTKatiaCalabrese_FernandoSouza_etal_IOC_2019.pdf.txtKatiaCalabrese_FernandoSouza_etal_IOC_2019.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa Essential Oils: Chemical Composition, Antimicrobial and Antileishmanial Activity
title Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa Essential Oils: Chemical Composition, Antimicrobial and Antileishmanial Activity
spellingShingle Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa Essential Oils: Chemical Composition, Antimicrobial and Antileishmanial Activity
Teles, Amanda Mara
Cinnamomum zeylanicum
Origanum vulgare
Curcuma longa
Óleos essenciais
Composição química
Atividade Antileishmanial
Atividade antimicrobiana
Cinnamomum zeylanicum
Origanum vulgare
Curcuma longa
Essential Oils
Antileishmanial Activity
Chemical Composition
Antimicrobial Activity
title_short Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa Essential Oils: Chemical Composition, Antimicrobial and Antileishmanial Activity
title_full Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa Essential Oils: Chemical Composition, Antimicrobial and Antileishmanial Activity
title_fullStr Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa Essential Oils: Chemical Composition, Antimicrobial and Antileishmanial Activity
title_full_unstemmed Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa Essential Oils: Chemical Composition, Antimicrobial and Antileishmanial Activity
title_sort Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa Essential Oils: Chemical Composition, Antimicrobial and Antileishmanial Activity
author Teles, Amanda Mara
author_facet Teles, Amanda Mara
Rosa, Taynan Dulce da Silva
Mouchrek, Adenilde Nascimento
Silva, Ana Lucia Abreu
Calabrese, Kátia da Silva
Souza, Fernando Almeida
author_role author
author2 Rosa, Taynan Dulce da Silva
Mouchrek, Adenilde Nascimento
Silva, Ana Lucia Abreu
Calabrese, Kátia da Silva
Souza, Fernando Almeida
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Teles, Amanda Mara
Rosa, Taynan Dulce da Silva
Mouchrek, Adenilde Nascimento
Silva, Ana Lucia Abreu
Calabrese, Kátia da Silva
Souza, Fernando Almeida
dc.subject.other.pt_BR.fl_str_mv Cinnamomum zeylanicum
Origanum vulgare
Curcuma longa
Óleos essenciais
Composição química
Atividade Antileishmanial
Atividade antimicrobiana
topic Cinnamomum zeylanicum
Origanum vulgare
Curcuma longa
Óleos essenciais
Composição química
Atividade Antileishmanial
Atividade antimicrobiana
Cinnamomum zeylanicum
Origanum vulgare
Curcuma longa
Essential Oils
Antileishmanial Activity
Chemical Composition
Antimicrobial Activity
dc.subject.en.pt_BR.fl_str_mv Cinnamomum zeylanicum
Origanum vulgare
Curcuma longa
Essential Oils
Antileishmanial Activity
Chemical Composition
Antimicrobial Activity
description Universidade Federal do Maranhão. Laboratório de Controle de Qualidade de Alimentos e Água. São Luís, MA, Brasil / Rede Nordeste de Biotecnologia. Ponto Focal Maranhão. São Luís, MA, Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-05-02T16:03:06Z
dc.date.available.fl_str_mv 2019-05-02T16:03:06Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TELES, Amanda Mara et al. Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa Essential Oils: Chemical Composition, Antimicrobial and Antileishmanial Activity. Evidence-Based Complementary and Alternative Medicine, Volume 2019, Article ID 2421965, 12p, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32916
dc.identifier.issn.pt_BR.fl_str_mv 1741-427X
dc.identifier.doi.none.fl_str_mv 10.1155/2019/2421695
dc.identifier.eissn.none.fl_str_mv 1741-4288
identifier_str_mv TELES, Amanda Mara et al. Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa Essential Oils: Chemical Composition, Antimicrobial and Antileishmanial Activity. Evidence-Based Complementary and Alternative Medicine, Volume 2019, Article ID 2421965, 12p, 2019.
1741-427X
10.1155/2019/2421695
1741-4288
url https://www.arca.fiocruz.br/handle/icict/32916
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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