Clinical and immunopathological findings during long term follow-up in Leishmania infantum experimentally infected dogs
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/24742 |
Resumo: | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil |
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Abbehusen, Melissa Moura CostaAlmeida, Valter dos AnjosSolcà, Manuela da SilvaPereira, Laís da SilvaCosta, Dirceu JoaquimSantana, Leonardo GilBozza, Patricia TorresFraga, Deborah Bittencourt MothéVeras, Patrícia Sampaio TavaresdosSantos, Washington Luis ConradoAndrade, Bruno de BezerrilBrodskyn, Claudia Ida2018-02-06T13:10:05Z2018-02-06T13:10:05Z2017ABBEHUSEN, M. M. C. et al. Clinical and immunopathological findings during long term follow-up in Leishmania infantum experimentally infected dogs. Scientific Reports, v. 7, p. 15914, 2017.2045-2322https://www.arca.fiocruz.br/handle/icict/2474210.1038/s41598-017-15651-8engNature Publishing GroupLeishmania InfantumLeishmaniose visceralLutzomyia longipalpisAnimaisCãesInfecçãoLeishmania InfantumVisceral leishmaniasisLutzomyia longipalpisAnimalsDogsInfectionClinical and immunopathological findings during long term follow-up in Leishmania infantum experimentally infected dogsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidade Estadual de Vitória da Conquista. Vitória da Conquista, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Biomanguinhos. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Medicina Veterinária e Zootecnia. Departamento de Medicina Veterinária Preventiva e Produção Animal. Salvador, BA, Brasil / Instituto de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Escola Bahiana de Medicina e Saúde Pública. Salvador, Ba, Brasil / Universidade Salvador. Laureate Universities. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil / Ministério da Ciência, Tecnologia e Inovação. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Serviço de Imunologia. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. São Paulo, SP, BrasilCanine Visceral Leishmaniasis (CVL) is caused by Leishmania infantum, which in the New World is transmitted by Lutzomyia longipalpis. While prospective clinical and immunological assessments of dogs experimentally challenged with L. infantum have been previously reported over a relatively short follow-up period, the long-term characterization of infected animals has not been performed to date. We evaluated dogs in a subclinical state for six years following experimental infection with L. infantum and Lu. longipalpis saliva, via an intradermal route, to characterize clinical, parasitological and immunological parameters arising from L. infantum experimental infection. We also assess these parameters in a group of naturally infected animals. The immune profiles of the experimentally and naturally infected animals exhibited increases of IFN-γ, IL-6 and IL-18, and decreases in TNF, IL-2, IL-8 and CXCL1, compared to controls. Our results indicate that over a six-year follow-up post-challenge, subclinically infected dogs presented low CVL clinical scores despite the persistence of Leishmania parasites in the lymph nodes, spleen and skin. Similarities observed among immune profiles in the context of experimental and natural infection seem to suggest that an enduring activation of the host immune response may lead to the control of parasite growth, thereby limiting disease severity.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24742/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAbbehusen MMC Clinical and immunopathological....pdfAbbehusen MMC Clinical and immunopathological....pdfapplication/pdf2860180https://www.arca.fiocruz.br/bitstream/icict/24742/2/Abbehusen%20MMC%20Clinical%20and%20immunopathological....pdfdad833195083634c210f7b64bb852987MD52TEXTAbbehusen MMC Clinical and immunopathological....pdf.txtAbbehusen MMC Clinical and immunopathological....pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Clinical and immunopathological findings during long term follow-up in Leishmania infantum experimentally infected dogs |
title |
Clinical and immunopathological findings during long term follow-up in Leishmania infantum experimentally infected dogs |
spellingShingle |
Clinical and immunopathological findings during long term follow-up in Leishmania infantum experimentally infected dogs Abbehusen, Melissa Moura Costa Leishmania Infantum Leishmaniose visceral Lutzomyia longipalpis Animais Cães Infecção Leishmania Infantum Visceral leishmaniasis Lutzomyia longipalpis Animals Dogs Infection |
title_short |
Clinical and immunopathological findings during long term follow-up in Leishmania infantum experimentally infected dogs |
title_full |
Clinical and immunopathological findings during long term follow-up in Leishmania infantum experimentally infected dogs |
title_fullStr |
Clinical and immunopathological findings during long term follow-up in Leishmania infantum experimentally infected dogs |
title_full_unstemmed |
Clinical and immunopathological findings during long term follow-up in Leishmania infantum experimentally infected dogs |
title_sort |
Clinical and immunopathological findings during long term follow-up in Leishmania infantum experimentally infected dogs |
author |
Abbehusen, Melissa Moura Costa |
author_facet |
Abbehusen, Melissa Moura Costa Almeida, Valter dos Anjos Solcà, Manuela da Silva Pereira, Laís da Silva Costa, Dirceu Joaquim Santana, Leonardo Gil Bozza, Patricia Torres Fraga, Deborah Bittencourt Mothé Veras, Patrícia Sampaio Tavares dosSantos, Washington Luis Conrado Andrade, Bruno de Bezerril Brodskyn, Claudia Ida |
author_role |
author |
author2 |
Almeida, Valter dos Anjos Solcà, Manuela da Silva Pereira, Laís da Silva Costa, Dirceu Joaquim Santana, Leonardo Gil Bozza, Patricia Torres Fraga, Deborah Bittencourt Mothé Veras, Patrícia Sampaio Tavares dosSantos, Washington Luis Conrado Andrade, Bruno de Bezerril Brodskyn, Claudia Ida |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Abbehusen, Melissa Moura Costa Almeida, Valter dos Anjos Solcà, Manuela da Silva Pereira, Laís da Silva Costa, Dirceu Joaquim Santana, Leonardo Gil Bozza, Patricia Torres Fraga, Deborah Bittencourt Mothé Veras, Patrícia Sampaio Tavares dosSantos, Washington Luis Conrado Andrade, Bruno de Bezerril Brodskyn, Claudia Ida |
dc.subject.other.pt_BR.fl_str_mv |
Leishmania Infantum Leishmaniose visceral Lutzomyia longipalpis Animais Cães Infecção |
topic |
Leishmania Infantum Leishmaniose visceral Lutzomyia longipalpis Animais Cães Infecção Leishmania Infantum Visceral leishmaniasis Lutzomyia longipalpis Animals Dogs Infection |
dc.subject.en.pt_BR.fl_str_mv |
Leishmania Infantum Visceral leishmaniasis Lutzomyia longipalpis Animals Dogs Infection |
description |
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2018-02-06T13:10:05Z |
dc.date.available.fl_str_mv |
2018-02-06T13:10:05Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ABBEHUSEN, M. M. C. et al. Clinical and immunopathological findings during long term follow-up in Leishmania infantum experimentally infected dogs. Scientific Reports, v. 7, p. 15914, 2017. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/24742 |
dc.identifier.issn.pt_BR.fl_str_mv |
2045-2322 |
dc.identifier.doi.none.fl_str_mv |
10.1038/s41598-017-15651-8 |
identifier_str_mv |
ABBEHUSEN, M. M. C. et al. Clinical and immunopathological findings during long term follow-up in Leishmania infantum experimentally infected dogs. Scientific Reports, v. 7, p. 15914, 2017. 2045-2322 10.1038/s41598-017-15651-8 |
url |
https://www.arca.fiocruz.br/handle/icict/24742 |
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eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
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