Clinical and ultramicroscopic myocardial randomized study of beating versus arrested heart for mitral surgery

Detalhes bibliográficos
Autor(a) principal: Cueva, Clotario Neptali Carrasco
Data de Publicação: 2013
Outros Autores: Rocha, Maiara dos Santos, Mendes, Carlos Maurício Cardeal, Freitas, Luiz Antonio Rodrigues de, Baucia, José Augusto, Badaró, Roberto José da Silva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7804
Resumo: Universidade Federal da Bahia. Medical School. Salvador, BA, Brasil
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spelling Cueva, Clotario Neptali CarrascoRocha, Maiara dos SantosMendes, Carlos Maurício CardealFreitas, Luiz Antonio Rodrigues deBaucia, José AugustoBadaró, Roberto José da Silva2014-06-09T14:26:26Z2014-06-09T14:26:26Z2013CUEVA, C. N. C. et al. Clinical and ultramicroscopic myocardial randomized study of beating versus arrested heart for mitral surgery. Revista Brasileira de Cirurgia Cardiovascular, v. 28, n. 2, p. 270-280, 2013.1678-974110.5935/1678-9741.20130038https://www.arca.fiocruz.br/handle/icict/7804engSociedade Brasileira de Cirurgia CardiovascularClinical and ultramicroscopic myocardial randomized study of beating versus arrested heart for mitral surgeryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Medical School. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Medical School. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Medical School. Salvador, BA, BrasilUniversidade Federal da Bahia. Medical School. Salvador, BA, BrasilINTRODUCTION: Beating heart surgery on normothermic bypass simulates physiologic cardiac status. OBJECTIVES: This study compared clinical and transmission electron microscopic aspects of myocardial protection during mitral valve replacement using warm retrograde perfusion in empty beating versus arrested heart with cold blood anterograde cardioplegia. METHODS: Randomized study to evaluate myocardial cellular ischemia-reperfusion of both techniques to replace the mitral valve. Thirty-four patients were randomly assigned into group A (beating heart) and group B (arrested heart). The following parameters were assessed: echocardiography, blood chemistry, hemoglobin, lactate. During the surgical procedure a total of 102 myocardial biopsies were performed for ultrastructural analysis from anterior left ventricular wall: before cardiopulmonary bypass, before aortic desclamping and 10 minutes after reperfusion. RESULTS: Elevation of lactate at 3 hours during the procedure was higher in group A, but similar at the end of surgery (P=0.06). Cardioversion was necessary in 5/17 (A) vs. 13/17 (B) P=0.07. Median intraoperative systemic temperature was significantly lower in the group B compared to A (32° C vs. 36° C), P<0.001. There was no significant difference of the ultramicroscopic aspects of the heart biopsies before, during and after surgery in both groups. Cellular and mitochondrial transient abnormalities such as mitochondrial swelling, glycogen loss and cytosol swelling were detected independently of the moment of the biopsies. CONCLUSION: Myocardial protection and ultrastructural abnormalities were similar for both types of mitral valve replacement beating or arrested heart techniques.Heart ArrestInducedMyocardiumMitralValveSurgeryPonte de Artéria Coronária sem Circulação Extracorpórea/métodosParada Cardíaca Induzida/métodosImplante de Prótese de Valva Cardíaca/métodosValva Mitral/cirurgiaMiocárdio/patologiaAdolescenteAdultoBiópsiaFemininoHumanosÁcido Láctico/sangueMasculinoMicroscopia Eletrônica de TransmissãoMeia-IdadeValva Mitral/patologiaMiocárdio/ultraestruturaPeríodo Pós-OperatórioEstudos ProspectivosFatores de TempoResultado do TratamentoAdulto Joveminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCueva CNC Clinical and ultramicroscopic....pdfCueva CNC Clinical and ultramicroscopic....pdfapplication/pdf1997890https://www.arca.fiocruz.br/bitstream/icict/7804/1/Cueva%20CNC%20Clinical%20and%20ultramicroscopic....pdfc985ead0e2654504f2890d4a3ae15d35MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7804/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTCueva CNC Clinical and ultramicroscopic....pdf.txtCueva CNC Clinical and ultramicroscopic....pdf.txtExtracted texttext/plain41417https://www.arca.fiocruz.br/bitstream/icict/7804/5/Cueva%20CNC%20Clinical%20and%20ultramicroscopic....pdf.txta6e0bebd06ab9c9fe66e2e5bcf5fca40MD55THUMBNAILCueva CNC Clinical and ultramicroscopic....pdf.jpgCueva CNC Clinical and ultramicroscopic....pdf.jpgGenerated Thumbnailimage/jpeg2129https://www.arca.fiocruz.br/bitstream/icict/7804/4/Cueva%20CNC%20Clinical%20and%20ultramicroscopic....pdf.jpgf3b57c0d62ea7e68795b1ed943ec80a9MD54icict/78042023-03-15 14:33:19.704oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:19Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Clinical and ultramicroscopic myocardial randomized study of beating versus arrested heart for mitral surgery
title Clinical and ultramicroscopic myocardial randomized study of beating versus arrested heart for mitral surgery
spellingShingle Clinical and ultramicroscopic myocardial randomized study of beating versus arrested heart for mitral surgery
Cueva, Clotario Neptali Carrasco
Heart Arrest
Induced
Myocardium
Mitral
Valve
Surgery
Ponte de Artéria Coronária sem Circulação Extracorpórea/métodos
Parada Cardíaca Induzida/métodos
Implante de Prótese de Valva Cardíaca/métodos
Valva Mitral/cirurgia
Miocárdio/patologia
Adolescente
Adulto
Biópsia
Feminino
Humanos
Ácido Láctico/sangue
Masculino
Microscopia Eletrônica de Transmissão
Meia-Idade
Valva Mitral/patologia
Miocárdio/ultraestrutura
Período Pós-Operatório
Estudos Prospectivos
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
title_short Clinical and ultramicroscopic myocardial randomized study of beating versus arrested heart for mitral surgery
title_full Clinical and ultramicroscopic myocardial randomized study of beating versus arrested heart for mitral surgery
title_fullStr Clinical and ultramicroscopic myocardial randomized study of beating versus arrested heart for mitral surgery
title_full_unstemmed Clinical and ultramicroscopic myocardial randomized study of beating versus arrested heart for mitral surgery
title_sort Clinical and ultramicroscopic myocardial randomized study of beating versus arrested heart for mitral surgery
author Cueva, Clotario Neptali Carrasco
author_facet Cueva, Clotario Neptali Carrasco
Rocha, Maiara dos Santos
Mendes, Carlos Maurício Cardeal
Freitas, Luiz Antonio Rodrigues de
Baucia, José Augusto
Badaró, Roberto José da Silva
author_role author
author2 Rocha, Maiara dos Santos
Mendes, Carlos Maurício Cardeal
Freitas, Luiz Antonio Rodrigues de
Baucia, José Augusto
Badaró, Roberto José da Silva
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Cueva, Clotario Neptali Carrasco
Rocha, Maiara dos Santos
Mendes, Carlos Maurício Cardeal
Freitas, Luiz Antonio Rodrigues de
Baucia, José Augusto
Badaró, Roberto José da Silva
dc.subject.en.pt_BR.fl_str_mv Heart Arrest
Induced
Myocardium
Mitral
Valve
Surgery
topic Heart Arrest
Induced
Myocardium
Mitral
Valve
Surgery
Ponte de Artéria Coronária sem Circulação Extracorpórea/métodos
Parada Cardíaca Induzida/métodos
Implante de Prótese de Valva Cardíaca/métodos
Valva Mitral/cirurgia
Miocárdio/patologia
Adolescente
Adulto
Biópsia
Feminino
Humanos
Ácido Láctico/sangue
Masculino
Microscopia Eletrônica de Transmissão
Meia-Idade
Valva Mitral/patologia
Miocárdio/ultraestrutura
Período Pós-Operatório
Estudos Prospectivos
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
dc.subject.decs.pt_BR.fl_str_mv Ponte de Artéria Coronária sem Circulação Extracorpórea/métodos
Parada Cardíaca Induzida/métodos
Implante de Prótese de Valva Cardíaca/métodos
Valva Mitral/cirurgia
Miocárdio/patologia
Adolescente
Adulto
Biópsia
Feminino
Humanos
Ácido Láctico/sangue
Masculino
Microscopia Eletrônica de Transmissão
Meia-Idade
Valva Mitral/patologia
Miocárdio/ultraestrutura
Período Pós-Operatório
Estudos Prospectivos
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
description Universidade Federal da Bahia. Medical School. Salvador, BA, Brasil
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-06-09T14:26:26Z
dc.date.available.fl_str_mv 2014-06-09T14:26:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CUEVA, C. N. C. et al. Clinical and ultramicroscopic myocardial randomized study of beating versus arrested heart for mitral surgery. Revista Brasileira de Cirurgia Cardiovascular, v. 28, n. 2, p. 270-280, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7804
dc.identifier.issn.none.fl_str_mv 1678-9741
10.5935/1678-9741.20130038
identifier_str_mv CUEVA, C. N. C. et al. Clinical and ultramicroscopic myocardial randomized study of beating versus arrested heart for mitral surgery. Revista Brasileira de Cirurgia Cardiovascular, v. 28, n. 2, p. 270-280, 2013.
1678-9741
10.5935/1678-9741.20130038
url https://www.arca.fiocruz.br/handle/icict/7804
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Cirurgia Cardiovascular
publisher.none.fl_str_mv Sociedade Brasileira de Cirurgia Cardiovascular
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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