Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblast-myofibroblast transition and increase in expression of extracellular matrix proteins
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/29313 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil. |
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Coelho, Laura LacerdaPereira, Isabela ResendePereira, Mirian Claudia de SouzaMesquita, LilianeLannes-Vieira, JoseliAdesse, DanielGarzoni, Luciana Ribeiro2018-10-04T11:31:41Z2018-10-04T11:31:41Z2018COELHO, Laura Lacerda; et al. Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblastmyofibroblast transition and increase in expression of extracellular matrix proteins. Parasites & Vectors, v.11, n.72, 11p, 2018.1756-3305https://www.arca.fiocruz.br/handle/icict/2931310.1186/s13071-018-2614-1engBioMed CentralDoença de ChagasTrypanosoma cruziFibroseMatriz ExtracelularFibroblastos cardíacosChagas disesaseTrypanosoma cruziFibrosisCardiac fibroblastsExtracellular matrixTrypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblast-myofibroblast transition and increase in expression of extracellular matrix proteinsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil.Cardiac fibrosis is a consequence of chronic chagasic cardiomyopathy (CCC). In other cardiovascular diseases, the protagonist role of fibroblasts in cardiac fibrosis is well established. However, the role of cardiac fibroblasts (CFs) in fibrosis during the CCC is not clear. Here, our aim was to investigate the effect of Trypanosoma cruzi, the etiological agent of Chagas disease on CFs activation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/29313/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALlauraL_coelho_etal_IOC_2018.pdflauraL_coelho_etal_IOC_2018.pdfapplication/pdf2573127https://www.arca.fiocruz.br/bitstream/icict/29313/2/lauraL_coelho_etal_IOC_2018.pdf0189ca9257f54bbaa2580afb1aa584c4MD52TEXTlauraL_coelho_etal_IOC_2018.pdf.txtlauraL_coelho_etal_IOC_2018.pdf.txtExtracted texttext/plain45972https://www.arca.fiocruz.br/bitstream/icict/29313/3/lauraL_coelho_etal_IOC_2018.pdf.txt72af7d3a2ea82530506e1f76573da082MD53icict/293132022-06-24 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| dc.title.pt_BR.fl_str_mv |
Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblast-myofibroblast transition and increase in expression of extracellular matrix proteins |
| title |
Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblast-myofibroblast transition and increase in expression of extracellular matrix proteins |
| spellingShingle |
Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblast-myofibroblast transition and increase in expression of extracellular matrix proteins Coelho, Laura Lacerda Doença de Chagas Trypanosoma cruzi Fibrose Matriz Extracelular Fibroblastos cardíacos Chagas disesase Trypanosoma cruzi Fibrosis Cardiac fibroblasts Extracellular matrix |
| title_short |
Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblast-myofibroblast transition and increase in expression of extracellular matrix proteins |
| title_full |
Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblast-myofibroblast transition and increase in expression of extracellular matrix proteins |
| title_fullStr |
Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblast-myofibroblast transition and increase in expression of extracellular matrix proteins |
| title_full_unstemmed |
Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblast-myofibroblast transition and increase in expression of extracellular matrix proteins |
| title_sort |
Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblast-myofibroblast transition and increase in expression of extracellular matrix proteins |
| author |
Coelho, Laura Lacerda |
| author_facet |
Coelho, Laura Lacerda Pereira, Isabela Resende Pereira, Mirian Claudia de Souza Mesquita, Liliane Lannes-Vieira, Joseli Adesse, Daniel Garzoni, Luciana Ribeiro |
| author_role |
author |
| author2 |
Pereira, Isabela Resende Pereira, Mirian Claudia de Souza Mesquita, Liliane Lannes-Vieira, Joseli Adesse, Daniel Garzoni, Luciana Ribeiro |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Coelho, Laura Lacerda Pereira, Isabela Resende Pereira, Mirian Claudia de Souza Mesquita, Liliane Lannes-Vieira, Joseli Adesse, Daniel Garzoni, Luciana Ribeiro |
| dc.subject.other.pt_BR.fl_str_mv |
Doença de Chagas Trypanosoma cruzi Fibrose Matriz Extracelular Fibroblastos cardíacos |
| topic |
Doença de Chagas Trypanosoma cruzi Fibrose Matriz Extracelular Fibroblastos cardíacos Chagas disesase Trypanosoma cruzi Fibrosis Cardiac fibroblasts Extracellular matrix |
| dc.subject.en.pt_BR.fl_str_mv |
Chagas disesase Trypanosoma cruzi Fibrosis Cardiac fibroblasts Extracellular matrix |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil. |
| publishDate |
2018 |
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2018-10-04T11:31:41Z |
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2018-10-04T11:31:41Z |
| dc.date.issued.fl_str_mv |
2018 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
COELHO, Laura Lacerda; et al. Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblastmyofibroblast transition and increase in expression of extracellular matrix proteins. Parasites & Vectors, v.11, n.72, 11p, 2018. |
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https://www.arca.fiocruz.br/handle/icict/29313 |
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1756-3305 |
| dc.identifier.doi.none.fl_str_mv |
10.1186/s13071-018-2614-1 |
| identifier_str_mv |
COELHO, Laura Lacerda; et al. Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblastmyofibroblast transition and increase in expression of extracellular matrix proteins. Parasites & Vectors, v.11, n.72, 11p, 2018. 1756-3305 10.1186/s13071-018-2614-1 |
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eng |
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BioMed Central |
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BioMed Central |
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